Results 11 to 20 of about 86,167 (192)

Chromosomal Instability in Meningiomas [PDF]

Journal of Neuropathology & Experimental Neurology, 2005
Approximately 60% of sporadic meningiomas are caused by inactivation of the NF2 tumor suppressor gene on chromosome 22. No causative gene is known for the remaining 40%. Cytogenetic analysis shows that meningiomas caused by inactivation of the NF2 gene can be divided into tumors that show monosomy 22 as the sole abnormality and tumors with a more ...
Tilborg, Angela, Al Allak, B, Velthuizen, Sandra, de Vries, A (Annie), Kros, J.M., Avezaat, CJJ, de Klein, Annelies, Beverloo, Berna, Zwarthoff, Ellen   +8 more
openaire   +3 more sources

Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers

Cancer Reports, 2023
Background Cancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive.
Sasha Taluri, Vishal H. Oza, Tabea M. Soelter, Jennifer L. Fisher, Brittany N. Lasseigne   +4 more
doaj   +1 more source

Characterization of Chromosomal Instability in Glioblastoma

Frontiers in Genetics, 2022
Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system (CNS). The poor prognosis of GBM due to resistance to therapy has been associated with high chromosomal instability (CIN).
Elisa Balzano, Elisa Balzano, Elena Di Tommaso, Elena Di Tommaso, Antonio Antoccia, Franca Pelliccia, Simona Giunta   +6 more
doaj   +1 more source

Genome-wide chromosomal instability by cell-free DNA sequencing predicts survival in patients with metastatic breast cancer

Breast, 2020
Background: Genome-wide chromosomal instability, instead of specific somatic mutations or copy-number alterations in selected genes, is a significant property of cancer and may suggest a new strategy for treatment.
Hongnan Mo, Xiaobing Wang, Fei Ma, Ziliang Qian, Xiaoying Sun, Zongbi Yi, Xiuwen Guan, Lixi Li, Binliang Liu, Binghe Xu   +9 more
doaj   +1 more source

Perceived Stress Levels, Chemotherapy, Radiation Treatment and Tumor Characteristics Are Associated with a Persistent Increased Frequency of Somatic Chromosomal Instability in Women Diagnosed with Breast Cancer: A One Year Longitudinal Study. [PDF]

PLoS ONE, 2015
While advances in therapeutic approaches have resulted in improved survival rates for women diagnosed with breast cancer, subsets of these survivors develop persistent psychoneurological symptoms (fatigue, depression/anxiety, cognitive dysfunction) that ...
Noran Aboalela, Debra Lyon, R K Elswick, Debra Lynch Kelly, Jenni Brumelle, Harry D Bear, Colleen Jackson-Cook   +6 more
doaj   +1 more source

Chromosomal instability in adult-type diffuse gliomas

Acta Neuropathologica Communications, 2022
Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying mechanism of tumorigenesis and malignant progression, and has been documented in a wide variety of cancers, including colorectal carcinoma with mutations in genes such
Timothy E. Richardson, Jamie M. Walker, Kalil G. Abdullah, Samuel K. McBrayer, Mariano S. Viapiano, Zarmeen M. Mussa, Nadejda M. Tsankova, Matija Snuderl, Kimmo J. Hatanpaa   +8 more
doaj   +1 more source

Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. [PDF]

PLoS ONE, 2012
Chromosomal instability is the major form of genomic instability in cancer cells. Amongst various forms of chromosomal instability, pericentromeric or centromeric instability remains particularly poorly understood.
Wen Deng, Sai Wah Tsao, Xin-Yuan Guan, Annie L M Cheung   +3 more
doaj   +1 more source

Multi-layered cancer chromosomal instability phenotype

Frontiers in Oncology, 2013
Whole chromosomal instability (W-CIN) – unequal chromosome distribution during cell division - is a characteristic feature of a majority of cancer cells distinguishing them from their normal counterparts.
Anna V Roschke, Ester eRozenblum
doaj   +1 more source

Cytogenetic studies of Myodes glareolus from the natural populations of the Chornobyl Exclusion Zone in the remote post-accident period [PDF]

Ядерна фізика та енергетика, 2022
The results of cytogenetic studies of bank voles (Myodes glareolus) carried out during 2009 - 2016 in the areas of the Chornobyl Exclusion Zone with different levels of radionuclide contamination are presented.
N. M. Riabchenko, O. O. Burdo, A. I. Lypska   +2 more
doaj   +1 more source

Telomere-Dependent Chromosomal Instability [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2005
Telomeres are specialized DNA-protein structures at the ends of the linear chromosomes. In mammalian cells, they are composed of multifold hexameric TTAGGG repeats and a number of associated proteins. The double-stranded telomeric DNA ends in a 3' single stranded overhang of 150 to 300 base pair (bp) which is believed to be required for a higher order ...
Boukamp, Petra, Popp, Susanne, Krunic, Damir   +2 more
openaire   +2 more sources