Results 21 to 30 of about 86,167 (192)
Molecular Cancer, 2003 Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability.
Cin Paola +3 more
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High-grade serous ovarian carcinoma organoids as models of chromosomal instability
eLife, 2023 High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity.
Maria Vias +13 more
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Mechanisms of Chromosomal Instability [PDF]
Current Biology, 2010 Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by ...
Thompson, Sarah L. +2 more
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Scientific Reports, 2021 Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye +9 more
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Neoplasia: An International Journal for Oncology Research, 2008 Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell population.
Anna V. Roschke +5 more
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In silico pathway analysis based on chromosomal instability in breast cancer patients
BMC Medical Genomics, 2020 Background Complex genomic changes that arise in tumors are a consequence of chromosomal instability. In tumor cells genomic aberrations disrupt core signaling pathways involving various genes, thus delineating of signaling pathways can help understand ...
Akeen Kour +6 more
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EMBO Molecular Medicine, 2020 Oncogene‐addicted tumors present a valuable target for therapeutic intervention and an opportunity to achieve a wide therapeutic window. Nonetheless, resistance to targeted therapies is frequently observed and it arises through multiple mechanisms ...
Daniel Bronder, Samuel F Bakhoum
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Chromosomal Instability in Gastric Cancer Biology
Neoplasia: An International Journal for Oncology Research, 2017 Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the total cancer incidence. The prognosis of GC is dismal in Western countries due to late diagnosis: approximately 70% of the patients die within 5 years following ...
Saffiyeh Saboor Maleki +1 more
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Molecular mechanism in a rare autosomal recessive case of xeroderma pigmentosum - a case report
National Journal of Clinical Anatomy, 2014 Chromosomal instability syndromes are a special group of disorders of cytogenetic interest which comprises of several rare, autosomal recessive conditions.
Vijaya Ramanathan, Anand Ramanathan
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DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF. [PDF]
PLoS Genetics, 2018 DNA replication stress (DRS) leads to the accumulation of stalled DNA replication forks leaving a fraction of genomic loci incompletely replicated, a source of chromosomal rearrangements during their partition in mitosis.
Rémy Bétous +5 more
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