Results 31 to 40 of about 86,167 (192)

Tetraploidy causes chromosomal instability in acentriolar mouse embryos

Nature Communications, 2019
During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability
Lia Mara Gomes Paim, Greg FitzHarris
doaj   +1 more source

A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. [PDF]

PLoS ONE, 2008
BackgroundPolyploidy is a prominent feature of many human cancers, and it has long been hypothesized that polyploidy may contribute to tumorigenesis by promoting genomic instability.
Meejeon Roh, Omar E Franco, Simon W Hayward, Riet van der Meer, Sarki A Abdulkadir   +4 more
doaj   +1 more source

Nucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer

npj Genomic Medicine, 2022
Fragmentation patterns of plasma cell-free DNA (cfDNA) are known to reflect nucleosome positions of cell types contributing to cfDNA. Based on cfDNA fragmentation patterns, the deviation in nucleosome footprints was quantified between diagnosed ovarian ...
Adriaan Vanderstichele, Pieter Busschaert, Chiara Landolfo, Siel Olbrecht, An Coosemans, Wouter Froyman, Liselore Loverix, Nicole Concin, Elena Ioana Braicu, Pauline Wimberger, Els Van Nieuwenhuysen, Sileny N. Han, Toon Van Gorp, Tom Venken, Ruben Heremans, Patrick Neven, Tom Bourne, Ben Van Calster, Dirk Timmerman, Diether Lambrechts, Ignace Vergote   +20 more
doaj   +1 more source

Drug Targeting of Genomic Instability in Multiple Myeloma

Frontiers in Genetics, 2020
Genomic instability can be observed at both chromosomal and chromatin levels. Instability at the macro level includes centrosome abnormalities (CA) resulting in numerical as well as structural chromosomal changes, whereas instability at the micro level ...
Meral Beksac, Sevinc Balli, Dilara Akcora Yildiz   +2 more
doaj   +1 more source

Alternative Splicing of CHEK2 and Codeletion with NF2 Promote Chromosomal Instability in Meningioma

Neoplasia: An International Journal for Oncology Research, 2012
Mutations of the NF2 gene on chromosome 22q are thought to initiate tumorigenesis in nearly 50% of meningiomas, and 22q deletion is the earliest and most frequent large-scale chromosomal abnormality observed in these tumors.
Hong Wei Yang, Tae-Min Kim, Sydney S. Song, Nihal Shrinath, Richard Park, Michel Kalamarides, Peter J. Park, Peter M. Black, Rona S. Carroll, Mark D. Johnson   +9 more
doaj   +1 more source

DNA Double-Strand Breaks Affect Chromosomal Rearrangements during Methotrexate-Mediated Gene Amplification in Chinese Hamster Ovary Cells

Pharmaceutics, 2021
Methotrexate (MTX)-mediated gene amplification has been widely used in Chinese hamster ovary (CHO) cells for the biomanufacturing of therapeutic proteins.
Jong Youn Baik, Hye-Jin Han, Kelvin H. Lee   +2 more
doaj   +1 more source

Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro.

PLoS ONE, 2018
Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug commonly administered to treat cryptococcosis. Unfortunately, FLC-resistant strains characterized
Congyue Annie Peng, Andrea A E Gaertner, Sarah Ana Henriquez, Diana Fang, Rodney J Colon-Reyes, Julia L Brumaghim, Lukasz Kozubowski   +6 more
doaj   +1 more source

A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

Nature Communications, 2022
Chromosomal instability caused by cell division errors is associated with antifungal drug resistance in fungal pathogens. Here, Jaitly et al. identify several genes involved in chromosomal stability in Candida albicans, including a phylogenetically ...
Priya Jaitly, Mélanie Legrand, Abhijit Das, Tejas Patel, Murielle Chauvel, Corinne Maufrais, Christophe d’Enfert, Kaustuv Sanyal   +7 more
doaj   +1 more source

Dynamic Features of Chromosomal Instability during Culture of Induced Pluripotent Stem Cells [PDF]

, 2022
Casey O. DuBose, John R. Daum, Christopher L. Sansam, Gary J. Gorbsky   +3 more
openalex   +1 more source

Increased chromosomal instability characterizes metastatic renal cell carcinoma

Translational Oncology, 2021
The evolutionary trajectories of treatment-naïve metastatic tumour are largely unknown. Such knowledge is crucial for cancer prevention and therapeutic interventions.
Qin Ma, Jilu Wang, Jie Qi, Ding Peng, Bao Guan, Jianye Zhang, Zhongwu Li, Hongxian Zhang, Ting Li, Yue Shi, Xuesong Li, Liqun Zhou, Ke Chen, Weimin Ci   +13 more
doaj   +1 more source