Results 61 to 70 of about 86,167 (192)

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Nature Communications, 2016
Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and ...
Weiguo Zhang, Jian-Hua Mao, Wei Zhu, Anshu K. Jain, Ke Liu, James B. Brown, Gary H. Karpen   +6 more
doaj   +1 more source

Long-term Culture of EBV-induced Human Lymphoblastoid Cell Lines Reveals Chromosomal Instability [PDF]

, 2020
Marianne Volleth, Martin Zenker, Ivana Joksić, Thomas Liehr   +3 more
openalex   +1 more source

Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability [PDF]

, 2013
Scott F. Lindsey, Diana M. Byrnes, Mark S. Eller, Ashley M. Rosa, Nitika Dabas, Julia Escandon, James M. Grichnik   +6 more
openalex   +1 more source

Single-cell mouse and PC9 data for "TP53 loss with whole genome doubling mediates heterogeneous intra-patient therapy response through Chromosomal Instability"

, 2023
Simone Zaccaria
openalex   +1 more source

Liability to Chromosome Damage in Lymphocytes of “Cancer Family” Subjects: A Study of Spontaneous and Induced Chromosomal Fragility

The International Journal of Biological Markers, 1987
Spontaneous chromosomal fragility was detected in seven tumor patients and one healthy member from two families with a high recurrence of cancer. Major chromosome lesions, such as terminal deletions and rearranged chromosomes, were found at levels ...
Lidia Larizza, Luisa Doneda, Miria Stefanini, Giuseppa Francone, Valter Gualandri, Annamaria Fuhrman Conti   +5 more
doaj   +1 more source

Chromosomal imbalance in the progression of high-risk non-muscle invasive bladder cancer

BMC Cancer, 2009
Background Non-muscle invasive bladder neoplasms with invasion of the lamina propria (stage T1) or high grade of dysplasia are at "high risk" of progression to life-threatening cancer. However, the individual course is difficult to predict.
Ørntoft Torben, Jensen Klaus, Wiuf Carsten, Zieger Karsten, Dyrskjøt Lars   +4 more
doaj   +1 more source

Chromosome Instability Drives Tumor Evolution [PDF]

Cancer Discovery, 2017
Abstract A prospective study of patients with non–small cell lung cancer undergoing treatment reveals that chromosomal instability and tumor heterogeneity drive disease recurrence. Researchers involved in the TRACERx trial documented that genetic diversity by sequencing multiple regions of the primary tumor and then created bespoke ctDNA
openaire   +2 more sources

Supplementary Figures S1-S2 from Loss of p53 and MCT-1 Overexpression Synergistically Promote Chromosome Instability and Tumorigenicity

, 2023
Ravi Kasiappan, Hung-Ju Shih, Kang-Lin Chu, Wei‐Ti Chen, Huiping Liu, Shiu-Feng Huang, Chik On Choy, Chung-Li Shu, Richard Din, Jan‐Show Chu, Hsin-Ling Hsu   +10 more
openalex   +2 more sources

Chromosomal instability is associated with prognosis and efficacy of bevacizumab after resection of colorectal cancer liver metastasis

Annals of Medicine
Introduction Individualized treatment of colorectal cancer liver metastases (CRLM) remains challenging due to differences in the severity of metastatic disease and tumour biology. Exploring specific prognostic risk subgroups is urgently needed.
Weihao Li, Jin Lan, Chi Zhou, Rong Yang, Jiayu Wang, Jiahua He, Binyi Xiao, Qingjian Ou, Yujing Fang, Wenhua Fan, Junzhong Lin, Zhizhong Pan, Jianhong Peng, Xiaojun Wu   +13 more
doaj   +1 more source

Supplementary Figure 5 from Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

, 2023
Sally M. Dewhurst, Nicholas McGranahan, Rebecca A. Burrell, Andrew J. Rowan, Eva Grönroos, David Endesfelder, Tejal Joshi, Dmitri Mouradov, Peter Gibbs, Robyn L. Ward, Nicholas J. Hawkins, Zoltán Szállási, Oliver M. Sieber, Charles Swanton   +13 more
openalex   +1 more source