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Targeted Chromosome Conformation Capture (HiCap)
Methods in Molecular Biology, 2022 Targeted chromosome conformation capture (HiCap) is an experimental method for detecting spatial interactions of genomic features such as promoters and/or enhancers. The protocol first describes the design of sequence capture probes.
Pelin Sahlén, Artemy Zhigulev
exaly +6 more sources
Quantitative Chromosome Conformation Capture (3C-qPCR)
Methods in Molecular Biology, 2022 International audienceMany population-based methods investigating chromatin dynamics and organization in eukaryotes are based on the Chromosome Conformation Capture (3C) method.
Thierry Forné
exaly +4 more sources
The Statistical-Mechanics of Chromosome Conformation Capture [PDF]
Nucleus, 2013 Since Jacob and Monod's characterization of the role of DNA elements in gene control, it has been recognized that the linear organization of genome structure is important for the regulation of gene transcription and hence the manifestation of phenotypes.
Jörg Langowski +2 more
exaly +3 more sources
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Chromosome Conformation Capture
Cold Spring Harbor Protocols, 2009INTRODUCTIONChromosome conformation capture (3C) is a technique used to detect the spatial organization of chromosomal DNA in fixed cells. DNA sequences in spatial proximity in the nucleus or engaged in physical interactions (such as those between genes and regulatory elements) can be assessed quantitatively to provide a measure that potentially ...
Nathan F, Cope, Peter, Fraser
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Capturing Chromosome Conformation
Science, 2002We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber.
Job, Dekker +3 more
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Chromosome Conformation Capture of Mitotic Chromosomes
2023Despite more than a century of intensive study of mitotic chromosomes, their three-dimensional organization remains enigmatic. The last decade established Hi-C as a method of choice for study of spatial genome-wide interactions. Although its utilization has been focused mainly on studying genomic interactions in interphase nuclei, the method can be ...
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Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
Journal of Visualized Experiments, 2023Chromosome conformation capture (3C) is a powerful tool that has spawned a family of similar techniques (e.g., Hi-C, 4C, and 5C, referred to here as 3C techniques) that provide detailed information of the three-dimensional organization of chromatin. The 3C techniques have been used in a wide range of studies, from monitoring the changes in chromatin ...
Joniec, Acadia +4 more
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Chromosome Conformation Capture for Large Genomes
2022The gigantic 32Gb Axolotl genome inspires fascinating questions such as: how such a big genome is organized and packed in nuclei and how regulation of gene transcription can happen over such large genomic distances. Currently, there are many technical challenges when we investigate chromatin architecture in axolotl.
Akane, Kawaguchi, Elly M, Tanaka
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Capturing Chromosome Conformation
2020The genome is organized in 3D topology-associated domains to ensure proper gene transcriptional processes. The chromosome conformation capture (3C) is an affordable method to investigate local chromatin structure and dynamics in cells and tissue. Herein I describe an easy to design and a cost-effective protocol.
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