Results 31 to 40 of about 30,958 (250)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

EVALUATION OF SOME GROWTH CHARACTERS AND ALKALOID PRODUCTIVITY OF DIPLOIDY AND TETRAPLOIDY FORMS OF Datura stramonium AND Datura innoxia PLANTS [PDF]

Journal of Soil Sciences and Agricultural Engineering, 2004
Field experiment was conducted to study the diversity in growth parameters and alkaloid production between diploidy and tetra ploidy levels of Datura stramonium and Datura innoxia plants. Increases in plant height.
A. A. Youssef, R. A. EI-Mergaw, M. S. Abdel-Wahed   +2 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Double deletion of a chromosome 21 inserted in a chromosome 22 in an azoospermic patient [PDF]

Clinical Case Reports, 2015
Key Clinical MessageWe report on a phenotypically normal 41‐year‐old azoospermic man with a 45 chromosomes karyotype including one normal chromosome 21, one normal chromosome 22, and a der(22)ins(22;21). ArrayCGHshowed a 1.8 Mb terminal deletion of bands 21pter to 21q21.1 and a 341 kb terminal deletion on band 21q22.3.
Marquet, Valentine, Bourgeois, Dominique, de Mas, Philippe, Bouneau, Laurence, Vigouroux‐castera, Adeline, Molignier, Romain, Calvas, Patrick   +6 more
openaire   +3 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Morphological, Cytological, and Molecular Comparison between Diploid and Induced Autotetraploids of Callisia fragrans (Lindl.) Woodson

Agronomy, 2022
The objective of the current study was to assess the efficiency of oryzalin in inducing polyploids in Callisia fragrans (Lindl.) Woodson by in vitro polyploidization.
Kateřina Beranová, Rohit Bharati, Jana Žiarovská, Jana Bilčíková, Kateřina Hamouzová, Miroslav Klíma, Eloy Fernández-Cusimamani   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Glioblastoma Multiforme with a Peculiar Chromosomal Aberration—Double Minute Chromosomes

Neurologia medico-chirurgica, 1987
The chromosomal aberration of double minute chromosomes (DMS) is a peculiar structural anomaly characterized by the occurrence of strongly varying numbers of often very small, paired chromatin bodies, in addition to the ordinary chromosomes. A glioblastoma multiforme with DMS was found in a 73-year-old female patient, who had received neither radiation
ARAKI, Osamu, MATSUNAGA, Morio, FUJITA, Yuzo, HAYASHI, Ken   +3 more
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source