Results 41 to 50 of about 30,070 (249)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Morphological, cytogenetic and molecular characterization of new somaclonal variants in four caladium (Caladium × hortulanum) cultivars

Ornamental Plant Research, 2023
The discovery of triploids in caladium has raised strong interest in their use in cultivar development. For triploid production, tetraploids must first be generated from elite breeding material without the introduction of deleterious alleles like has ...
S. Brooks Parrish, Michael E. Kane, Zhanao Deng   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Genes and genetics belong to maize haploid induction

Frontiers in Plant Science
Maize (Zea mays L.) is a globally significant cereal crop with diverse food, feed, and industry uses. The rapid development of homozygous inbred lines via double haploid (DH) technology has revolutionized maize breeding, reducing the time and cost ...
Kanogporn Khammona, Kanogporn Khammona, Abil Dermail, Yu-Ru Chen, Thomas Lübberstedt, Samart Wanchana, Theerayut Toojinda, Siwaret Arikit, Siwaret Arikit, Vinitchan Ruanjaichon   +9 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Moldovan line MHI the source for obtaining a large number of haploid plants in maize [PDF]

Selekcija i Semenarstvo, 2004
The hypothesis of the shortening the cycle of selection was tested in maize, by using the MHI line (Moldovan Haploid Inducer) for inducing haploids in five F1 elite single crosses, made for the purposes of further inbreeding and gaining new elite inbred ...
Vančetović Jelena M., Vidaković D., Ignjatović-Micić K., Marković N., Delić J.   +4 more
doaj  

Effect of polyploidization on morphology in two apple (Malus × domestica) genotypes

Horticultural Science, 2017
Because polyploidy often results in enhancement of desirable properties, artificial genome doubling is commonly used in agri- and horticultural crop breeding programs. In this study genome doubling was induced in two apple genotypes.
Niek Hias, Leen Leus, Mark W. Davey, Stijn Vanderzande, Johan Van Huylenbroeck, Johan Keulemans   +5 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Production of Doubled Haploids in Onion: A Review

Journal of Horticultural Sciences, 2014
Onion suffers from high inbreeding depression and, as a result, inbreds that are developed lack genotypic and phenotypic uniformity. Gynogenesis has emerged as a potential strategy to address this drawback.
A S Dhatt, Prerna Thakur
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source