Surveillance of cohesin-supported chromosome structure controls meiotic progression
Nature Communications, 2020 Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a ...
Maikel Castellano-Pozo +6 more
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The parameters of Menzerath-Altmann law in genomes [PDF]
, 2012 The relationship between the size of the whole and the size of the parts in language and music is known to follow Menzerath-Altmann law at many levels of description (morphemes, words, sentences...). Qualitatively, the law states that larger the whole, the smaller its parts, e.g., the longer a word (in syllables) the shorter its syllables (in letters ...
arxiv +1 more source
The effects of the promotor region of the 240bp repeats of the rRNA genes on x-y chromosome disjunction in Drosophila melanogaster males [PDF]
, 2000 Pairing between homologous chromosomes is essential for successful meiosis. In Drosophila melanogaster males, sex chromosome pairing during meiosis I is mediated by rDNA, located in heterochromatin.
Lee, Yunsang
core +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Introgression of the Aegilops speltoides Su1-Ph1 Suppressor into Wheat
Frontiers in Plant Science, 2017 Meiotic pairing between homoeologous chromosomes in polyploid wheat is inhibited by the Ph1 locus on the long arm of chromosome 5 in the B genome.
Hao Li +5 more
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Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status. [PDF]
PLoS ONE, 2012 Although somatic homologous pairing is common in Drosophila it is not generally observed in mammalian cells. However, a number of regions have recently been shown to come into close proximity with their homologous allele, and it has been proposed that ...
Christel Krueger +7 more
doaj +1 more source
Evolutionary dynamics of adult stem cells: Comparison of random and immortal strand segregation mechanisms [PDF]
, 2004 This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer. We consider two modes of chromosome segregation: (1) Random segregation, where the daughter chromosomes of a given parent chromosome ...
arxiv +1 more source
Mapping a meiotic pairing site in the second chromosome of Drosophila melanogaster males [PDF]
, 1995 Homologous chromosome pairing at early meiotic prophase I is very important for key meiotic events such as chromosome segregation and recombination, but little is known about the process. One approach to further understanding of the process of chromosome
Takano, Nobuya
core +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Sequence analysis of wheat subtelomeres reveals a high polymorphism among homoeologous chromosomes
The Plant Genome, 2020 Bread wheat, Triticum aestivum L., is one of the most important crops in the world. Understanding its genome organization (allohexaploid; AABBDD; 2n = 6x = 42) is essential for geneticists and plant breeders. Particularly, the knowledge of how homologous
Miguel Aguilar, Pilar Prieto
doaj +1 more source