Results 101 to 110 of about 178,325 (322)

A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]

, 2015
Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco, DE ROOIJ, DIRK GIJSBERT, Di Cecca, Stefano, DI GIACOMO, Monica, DI SIENA, Sara, Faieta, Monica, Luchetti, Andrea, Murdocca, Michela, Pellegrini, Manuela, Rossi, Pellegrino   +9 more
core   +3 more sources

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

Advanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia, Fuwen Wang, Xiaoyu Luo, Shuang Li, Yang Lyu, Yining Zheng, Zhijie Ma, Kaixing Qu, Rende Song, Jianyong Liu, Jicai Zhang, Basang Wangdui, Basang Zhuzha, Suolang Quji, Li Zhao, Silang Wangmu, Ciren Luobu, Nima Cangjue, Danzeng Luosang, Suolang Sizhu, Haijian Cheng, Ruizhe Li, Zhipeng Wu, Ruihua Dang, Yongzhen Huang, Xianyong Lan, Luohao Xu, Haifei Hu, WaiYee Low, Zhuqing Zheng, Yu Wang, Yuanpeng Gao, Lu Deng, Johannes A. Lenstra, Jianlin Han, Xueyi Yang, Wenfa Lyu, Bizhi Huang, Chuzhao Lei, Ningbo Chen   +39 more
wiley   +1 more source

The coordination of nuclear envelope assembly and chromosome segregation in metazoans

Nucleus, 2020
The nuclear envelope (NE) is composed of two lipid bilayer membranes that enclose the eukaryotic genome. In interphase, the NE is perforated by thousands of nuclear pore complexes (NPCs), which allow transport in and out of the nucleus. During mitosis in
Shiwei Liu, David Pellman
doaj   +1 more source

Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]

, 2020
Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D., Greig, D., Janzen, T., Nolte, A., Stelkens, R., Zhang, Z.   +5 more
core   +1 more source

Blood Biomarker‐Based Predictive Indicator for Liver Metastasis in Alpha‐Fetoprotein‐Producing Gastric Cancer and Multi‐Omics Tumor Microenvironment Insights

Advanced Science, EarlyView.
Alpha‐fetoprotein‐producing gastric cancer (AFPGC), a rare and aggressive subtype of gastric cancer, presents a high risk of liver metastasis. This study introduces the ANLiM score, a blood biomarker‐based predictive indicator for assessing liver metastasis and immunotherapy response.
Yongfeng Ding, Yiran Chen, Jing Zhang, Qingrui Wang, Songting Zhu, Junjie Jiang, Chao He, Jincheng Wang, Laizhen Tou, Jingwei Zheng, Bicheng Chen, Sizhe Hu, Xiongfei Yu, Haohao Wang, Yimin Lu, Mei Kong, Yanyan Chen, Haiyong Wang, Haibin Zhang, Hongxia Xu, Fei Teng, Xian Shen, Nong Xu, Jian Ruan, Zhan Zhou, Jun Lu, Lisong Teng   +26 more
wiley   +1 more source

Entropy as the driver of chromosome segregation [PDF]

Nature Reviews Microbiology, 2010
We present a new physical biology approach to understanding the relationship between the organization and segregation of bacterial chromosomes. We posit that replicated Escherichia coli daughter strands will spontaneously demix as a result of entropic forces, despite their strong confinement within the cell; in other words, we propose that entropy can ...
Andrew Wright, Suckjoon Jun
openaire   +2 more sources

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]

, 2018
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core   +1 more source

Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length

Advanced Science, EarlyView.
Different from mitosis, the female meiosis undergoes asymmetric division that produces haploid oocytes and polar body, which is essential for retaining maternal components to support subsequent fertilization and embryo development. However, the underlying mechanisms are still largely unknown.
Yu Li, Hanwen Zhang, Wenjun Zeng, Yilong Miao, Shaochen Sun, Yu Zhang, Bo Xiong   +6 more
wiley   +1 more source

Towards Synthetic Life: Establishing a Minimal Segrosome for the Rational Design of Biomimetic Systems [PDF]

, 2018
DNA segregation is a fundamental life process, crucial for renewal, reproduction and propagation of all forms of life. Hence, a dedicated segregation machinery, a segrosome, must function reliably also in the context of a minimal cell.
Hürtgen, Daniel
core   +1 more source

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source