Results 101 to 110 of about 995,917 (290)
Molecular & Cellular Oncology, 2017 Proper chromosome segregation relies on a functional centromere–kinetochore interface. We showed that chromatin containing CENtromere Protein A (CENP-A) is essential for centromere assembly, but dispensable for chromosome segregation in the presence of ...
S. Hoffmann, D. Fachinetti
doaj +1 more source
Cell Reports, 2013 Homologous recombination leads to the formation of DNA joint molecules (JMs) that must be resolved to allow chromosome segregation, but how resolution is temporally coupled with chromosome segregation is unknown.
Joao Matos +2 more
doaj +1 more source
Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle [PDF]
arXiv, 2022 During cell division, the spindle generates force to move chromosomes. In mammals, microtubule bundles called kinetochore-fibers (k-fibers) attach to and segregate chromosomes. To do so, k-fibers must be robustly anchored to the dynamic spindle. We previously developed microneedle manipulation to mechanically challenge k-fiber anchorage, and observed ...
arxiv
Segregating Chromosomes in the Mammalian Oocyte [PDF]
Current Biology, 2018 Chromosome segregation errors in human oocytes lead to aneuploid embryos that cause infertility and birth defects. Here we provide an overview of the chromosome-segregation process in the mammalian oocyte, highlighting mechanistic differences between oocytes and somatic cells that render oocytes so prone to segregation error.
Greg FitzHarris +1 more
openaire +3 more sources
mBio, 2019 Coordinating chromosome duplication and segregation with cell division is clearly critical for bacterial species with one chromosome. The precise choreography required is even more complex in species with more than one chromosome.
Nelly Dubarry +4 more
doaj +1 more source
Meiotic spindle assembly and chromosome segregation in oocytes
Journal of Cell Biology, 2016 Centrosomes play a key role in organizing the microtubule spindle that separates chromosomes during mitosis. Bennabi et al. review how microtubule spindle formation and chromosomal segregation also occur in oocytes during cell division by meiosis despite
Isma Bennabi, M. Terret, M. Verlhac
semanticscholar +1 more source
The mre11 A470 Alleles Influence the. Heritability and Segregation of Telosomes in Saccharomyces cerevisiae [PDF]
PLoS ONE 12(9): e0183549.,2017, 2017 Telomeres, the nucleoprotein complexes at the termini of linear chromosomes, are essential for the processes of end replication, end-protection, and chromatin segregation. The Mre11 complex is involved in multiple cellular roles in DNA repair and structure in the regulation and function of telomere size homeostasis. In this study, we characterize yeast
arxiv +1 more source
A novel chromosome segregation mechanism during female meiosis. [PDF]
, 2016 In a wide range of eukaryotes, chromosome segregation occurs through anaphase A, in which chromosomes move toward stationary spindle poles, anaphase B, in which chromosomes move at the same velocity as outwardly moving spindle poles, or both. In contrast,
Cortes, Daniel B +4 more
core +1 more source
Entropy as the driver of chromosome segregation [PDF]
Nature Reviews Microbiology, 2010 We present a new physical biology approach to understanding the relationship between the organization and segregation of bacterial chromosomes. We posit that replicated Escherichia coli daughter strands will spontaneously demix as a result of entropic forces, despite their strong confinement within the cell; in other words, we propose that entropy can ...
Andrew Wright, Suckjoon Jun
openaire +2 more sources
Segregation patterns of Neurospora chromosome ends: mapping chromosome tips. [PDF]
, 1989 Segregation patterns of Neurospora chromosome ends: mapping chromosome ...
Schechtman, M. G.
core +3 more sources