Results 121 to 130 of about 995,917 (290)

Temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast. [PDF]

PLoS ONE, 2009
BACKGROUND:In many organisms, homologous chromosomes rely upon recombination-mediated linkages, termed crossovers, to promote their accurate segregation at meiosis I.
Andrew Chi-Ho Chan, Rhona H Borts, Eva Hoffmann   +2 more
doaj   +1 more source

Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells

Scientific Reports, 2015
Tumor Treating Fields (TTFields) are low intensity, intermediate frequency, alternating electric fields. TTFields are a unique anti-mitotic treatment modality delivered in a continuous, noninvasive manner to the region of a tumor.
M. Giladi, R. Schneiderman, T. Voloshin, Y. Porat, M. Munster, R. Blat, Shay Sherbo, Z. Bomzon, N. Urman, A. Itzhaki, S. Cahal, A. Shteingauz, A. Chaudhry, E. Kirson, U. Weinberg, Y. Palti   +15 more
semanticscholar   +1 more source

Loop-extruders alter bacterial chromosome topology to direct entropic forces for segregation

Nature Communications
Entropic forces have been argued to drive bacterial chromosome segregation during replication. In many bacterial species, however, specifically evolved mechanisms, such as loop-extruding SMC complexes and the ParABS origin segregation system, contribute ...
Janni Harju, Muriel C. F. van Teeseling, Chase P. Broedersz   +2 more
doaj   +1 more source

Insensitivity of Chromosome I and the Cell Cycle to Blockage of Replication and Segregation of Vibrio cholerae Chromosome II

mBio, 2012
Vibrio cholerae has two chromosomes (chrI and chrII) whose replication and segregation are under different genetic controls. The region covering the replication origin of chrI resembles that of the Escherichia coli chromosome, and both origins are under ...
Ryosuke Kadoya, Dhruba K. Chattoraj
doaj   +1 more source

Alternating Dynamics of oriC, SMC, and MksBEF in Segregation of Pseudomonas aeruginosa Chromosome

mSphere, 2020
Condensins are essential for global chromosome organization in diverse bacteria. Atypically, the Pseudomonas aeruginosa chromosome encodes condensins from two superfamilies, SMC-ScpAB and MksBEF.
Hang Zhao, Bijit K. Bhowmik, Zoya M. Petrushenko, Valentin V. Rybenkov   +3 more
doaj   +1 more source

Regional Control of Chromosome Segregation in Pseudomonas aeruginosa

PLoS Genetics, 2016
Chromosome segregation in bacteria occurs concomitantly with DNA replication, and the duplicated regions containing the replication origin oriC are generally the first to separate and migrate to their final specific location inside the cell.
Valentine Lagage, F. Boccard, Isabelle Vallet-Gely   +2 more
semanticscholar   +1 more source

“Genome-wide recombination and chromosome segregation in human oocytes and embryos reveal selection for maternal recombination rates”

Nature Genetics, 2015
Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here we generate genome-wide maps of crossovers
C. Ottolini, Louise J. Newnham, A. Capalbo, Senthilkumar A. Natesan, Hrishikesh A. Joshi, D. Cimadomo, D. Griffin, K. Sage, M. Summers, A. Thornhill, E. Housworth, Alex D Herbert, L. Rienzi, F. Ubaldi, A. Handyside, E. Hoffmann   +15 more
semanticscholar   +1 more source

Distinct functions of S. pombe Rec12 (Spo11) protein and Rec12-dependent crossover recombination (chiasmata) in meiosis I; and a requirement for Rec12 in meiosis II [PDF]

, 2002
BACKGROUND: In most organisms proper reductional chromosome segregation during meiosis I is strongly correlated with the presence of crossover recombination structures (chiasmata); recombination deficient mutants lack crossovers and suffer meiosis I ...
Davidson, Mari K, Glick, Gloria G, Sharif, Wallace D, Wahls, Wayne P   +3 more
core   +2 more sources

Integrative genomics analysis identifies pericentromeric regions of human chromosomes affecting patterns of inter-chromosomal interactions [PDF]

arXiv, 2014
Genome-wide analysis of distributions of densities of long-range interactions of human chromosomes with each other, nucleoli, nuclear lamina, and binding sites of chromatin state regulatory proteins, CTCF and STAT1, identifies non-random highly correlated patterns of density distributions along the chromosome length for all these features.
arxiv  

The spindle checkpoint and chromosome segregation in meiosis

The FEBS Journal, 2015
The spindle checkpoint is a key regulator of chromosome segregation in mitosis and meiosis. Its function is to prevent precocious anaphase onset before chromosomes have achieved bipolar attachment to the spindle.
G. Gorbsky
semanticscholar   +1 more source