Results 51 to 60 of about 187,172 (325)

Spindle mechanics and chromosome segregation

Molecular Biology of the Cell, 2019
The Minisymposium “Spindle Mechanics and Chromosome Segregation” featured new and exciting findings related to the spindle and chromosomes during mitosis and meiosis. It covered a range of topics including spindle architecture and mechanics, kinetochore–microtubule interactions, chromosome dynamics at mitotic entry and exit, as well as mitotic errors ...
Daniel W. Gerlich, Iva M. Tolić
openaire   +5 more sources

Deregulation of Chromosome Segregation and Cancer [PDF]

Annual Review of Cancer Biology, 2020
The mitotic spindle assembly checkpoint (SAC) is an intricate cell signaling system that ensures the high fidelity and timely segregation of chromosomes during cell division. Mistakes in this process can lead to the loss, gain, or rearrangement of the genetic material. Gross chromosomal aberrations are usually lethal but can cause birth and development
Curtis, Natalie L., Filippo Ruda, Gian Filippo, Brennan, Paul, Bolanos-Garcia, Victor M.   +3 more
openaire   +3 more sources

A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere. [PDF]

PLoS Genetics, 2016
Transcriptional inactivation of the budding yeast centromere has been a widely used tool in studies of chromosome segregation and aneuploidy. In haploid cells when an essential chromosome contains a single conditionally inactivated centromere (GAL-CEN ...
Michael Tsabar, Julian Haase, Benjamin Harrison, Chloe E Snider, Brittany Eldridge, Lila Kaminsky, Rebecca M Hine, James E Haber, Kerry Bloom   +8 more
doaj   +1 more source

Coordination of Chromosome Segregation and Cell Division in Staphylococcus aureus [PDF]

, 2017
Productive bacterial cell division and survival of progeny requires tight coordination between chromosome segregation and cell division to ensure equal partitioning of DNA.
Adams, Arnaud, Bach, Ben-Yehuda, Bernhardt, Bi, Bisson-Filho, Bramkamp, Bramkamp, Britton, Brzoska, Bukau, Bukau, Busiek, Calloni, Claessen, Cooper, Cristea, Cristea, Daley, de Boer, Donovan, Donovan, Erickson, Fadda, Fleurie, Gatlin, Gregory, Gruber, Halbedel, Ireton, Ishikawa, Jensen, Karimova, Kato, Kloosterman, Kraemer, Landgraf, Lee, Lenarcic, Letek, Liew, Lutkenhaus, Marston, Minnen, Mohl, Novick, Oliva, Osawa, Patrick, Pereira, Pinho, Pinho, Pinho, Ramamurthi, Ramirez-Arcos, Rico, Schulz, Sieger, Singh, Steele, Sugimoto, Sullivan, Treuner-Lange, Turner, Tzagoloff, van Baarle, Varley, Veiga, Veiga, Willemse, Wu, Yang, Yu   +73 more
core   +3 more sources

SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae [PDF]

, 2011
Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans ...
Anna T. Vetter, Beth A. Sullivan, Delphine Theodorou, Edoardo Petrini, Felix Krueger, J. Ross Miller, Konrad Paszkiewicz, Margaret R. Crawford, Mickaël Durand-Dubief, Nicholas A. Kent, Patrick Varga-Weisz, Rachael R. Harris, Rosa Maria Correra, William Ryan Will   +13 more
core   +8 more sources

Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent

Cell Reports, 2016
Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for high-resolution fluorescence imaging (SeeDB2).
Meng-Tsen Ke, Yasuhiro Nakai, Satoshi Fujimoto, Rie Takayama, Shuhei Yoshida, Tomoya S. Kitajima, Makoto Sato, Takeshi Imai   +7 more
doaj   +1 more source

Age-cumulative effect of REC8 reduction on meiotic chromosome segregation errors in mice

Reproductive and Developmental Medicine, 2021
Objective: This study aimed to explore the relationship between cohesin subunit REC8 reduction and meiosis chromosome segregation errors in the ovary. Methods: Rec8+/− mice were generated using CRIPSR/Cas9 gene editing.
Li-Yuan Tian, Ling Zhang, Cheng-Qiu Tao, Xiao-Qi Lin, Feng Zhang, Bin Zhang   +5 more
doaj   +1 more source

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +2 more sources

Non-random Mis-segregation of Human Chromosomes

Cell Reports, 2018
Summary: A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a ...
Joseph Thomas Worrall, Naoka Tamura, Alice Mazzagatti, Nadeem Shaikh, Tineke van Lingen, Bjorn Bakker, Diana Carolina Johanna Spierings, Elina Vladimirou, Floris Foijer, Sarah Elizabeth McClelland   +9 more
doaj   +1 more source

Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]

, 2014
The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core   +2 more sources