CHROMOSOME SEGREGATION MECHANISMS [PDF]
Genetics, 1974 ABSTRACT Most aspects of chromosome distribution to the daughter cells in meiosis and mitosis are now understood, at the cellular level. The most striking evidence that the proposed explanation is valid is that it correctly predicts the outcome of experiments on living cells in which the experimenter (1) can determine the distribution of
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Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors
Human Reproduction Update, 2018 BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-prone, especially with ageing. Such errors markedly reduce the reproductive chances of increasing numbers of women embarking on pregnancy later in life.
Jessica Greaney, Zhe Wei, H. Homer
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Chromosome segregation analysis in human embryos obtained from couples involving male carriers of reciprocal or Robertsonian translocation. [PDF]
PLoS ONE, 2012 The objective of this study was to investigate the frequency and type of chromosome segregation patterns in cleavage stage embryos obtained from male carriers of Robertsonian (ROB) and reciprocal (REC) translocations undergoing preimplantation genetic ...
Ahmet Yilmaz +5 more
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Chromosome segregation impacts on cell growth and division site selection in Corynebacterium glutamicum. [PDF]
, 2013 Spatial and temporal regulation of bacterial cell division is imperative for the production of viable offspring. In many rod-shaped bacteria, regulatory systems such as the Min system and nucleoid occlusion ensure the high fidelity of midcell divisome ...
Bramkamp, Marc +3 more
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Bacterial Chromosome Organization and Segregation [PDF]
Annual Review of Cell and Developmental Biology, 2015 If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is compatible with a range of cellular processes, including DNA replication, DNA repair, homologous ...
Badrinarayanan, Anjana +2 more
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Causes and consequences of chromosome segregation error in preimplantation embryos.
Reproduction, 2018 Errors in chromosome segregation are common during the mitotic divisions of preimplantation development in mammalian embryos, giving rise to so-called 'mosaic' embryos possessing a mixture of euploid and aneuploid cells. Mosaicism is widely considered to
Cayetana Vázquez-Diez, G. Fitzharris
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The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. [PDF]
, 2015 Chromosome segregation during anaphase depends on chromosome-to-pole motility and pole-to-pole separation. We propose that in Drosophila embryos, the latter process (anaphase B) depends on a persistent kinesin-5-generated interpolar (ip) microtubule (MT)
Brust-Mascher, Ingrid +2 more
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Chromosome Segregation: Correcting Improperly Attached Chromosomes [PDF]
Current Biology, 2006 Two new studies show that Aurora B kinase corrects improperly attached chromosomes by recruiting molecules necessary for eliminating the bad attachments and by regulating the turnover of the kinetochore fiber.
Xin Zhang, Claire E. Walczak
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A simple biophysical model emulates budding yeast chromosome condensation
eLife, 2015 Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast ...
Tammy MK Cheng +8 more
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Human Reproduction Update, 2017 BACKGROUND The unbalanced transmission of chromosomes in human gametes and early preimplantation embryos causes aneuploidy, which is a major cause of infertility and pregnancy failure.
A. Capalbo +4 more
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