Bacterial chromosome segregation.
Acta Biochimica Polonica, 2005 In most bacteria two vital processes of the cell cycle: DNA replication and chromosome segregation overlap temporally. The action of replication machinery in a fixed location in the cell leads to the duplication of oriC regions, their rapid separation to the opposite halves of the cell and the duplicated chromosomes gradually moving to the same ...
Aneta A. Bartosik, Grazyna Jagura-Burdzy
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Deregulation of Chromosome Segregation and Cancer [PDF]
Annual Review of Cancer Biology, 2020 The mitotic spindle assembly checkpoint (SAC) is an intricate cell signaling system that ensures the high fidelity and timely segregation of chromosomes during cell division. Mistakes in this process can lead to the loss, gain, or rearrangement of the genetic material. Gross chromosomal aberrations are usually lethal but can cause birth and development
Curtis, Natalie L. +3 more
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A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. [PDF]
, 2019 Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress.
Brimacombe, Cedric A +8 more
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Segregation of Polymers in Confined Spaces [PDF]
Phys. Biol. 9 066005 ( 2012), 2009 We investigate the motion of two overlapping polymers with self-avoidance confined in a narrow 2d box. A statistical model is constructed using blob free-energy arguments. We find spontaneous segregation under the condition: $L > R_{//}$, and mixing under $L < R_{//}$, where L is the length of the box, and $R_{//}$ the polymer extension in an infinite ...
arxiv +1 more source
Spo0J and SMC are required for normal chromosome segregation in Staphylococcus aureus
MicrobiologyOpen, 2020 Bacterial chromosome segregation is an essential cellular process that is particularly elusive in spherical bacteria such as the opportunistic human pathogen Staphylococcus aureus.
Helena Chan +2 more
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A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere. [PDF]
PLoS Genetics, 2016 Transcriptional inactivation of the budding yeast centromere has been a widely used tool in studies of chromosome segregation and aneuploidy. In haploid cells when an essential chromosome contains a single conditionally inactivated centromere (GAL-CEN ...
Michael Tsabar +8 more
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Long-Range Repulsion Between Chromosomes in Mammalian Oocyte Spindles [PDF]
arXiv, 2022 During eukaryotic cell division, a microtubule-based structure called the spindle exerts forces on chromosomes, thereby organizing and segregating them Extensive work demonstrates that the forces acting parallel to the spindle axis, including those responsible for separating sister chromatids, are generated by microtubule polymerization and ...
arxiv
Age-cumulative effect of REC8 reduction on meiotic chromosome segregation errors in mice
Reproductive and Developmental Medicine, 2021 Objective: This study aimed to explore the relationship between cohesin subunit REC8 reduction and meiosis chromosome segregation errors in the ovary. Methods: Rec8+/− mice were generated using CRIPSR/Cas9 gene editing.
Li-Yuan Tian +5 more
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DNA-polymer architecture orchestrates the segregation and spatio-temporal organization of E. coli chromosomes during replication in slow growth [PDF]
arXiv, 2021 The mechanism and driving forces of chromosome segregation in the bacterial cell cycle of E. coli is one of the least understood events in its life cycle. Using principles of entropic repulsion between polymer loops confined in a cylinder, we use Monte carlo simulations to show that the segregation dynamics is spontaneously enhanced by the adoption of ...
arxiv
Random Chromosome Partitioning in the Polyploid Bacterium Thermus thermophilus HB27
G3: Genes, Genomes, Genetics, 2019 Little is known about chromosome segregation in polyploid prokaryotes. In this study, whether stringent or variable chromosome segregation occurs in polyploid thermophilic bacterium Thermus thermophilus was analyzed.
Haijuan Li
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