Results 51 to 60 of about 923,115 (353)

Multimodal effects of small molecule ROCK and LIMK inhibitors on mitosis, and their implication as anti-leukemia agents. [PDF]

PLoS ONE, 2014
Accurate chromosome segregation is vital for cell viability. Many cancer cells show chromosome instability (CIN) due to aberrant expression of the genes involved in chromosome segregation.
Yusuke Oku, Chiaki Tareyanagi, Shinichi Takaya, Sayaka Osaka, Haruki Ujiie, Kentaro Yoshida, Naoyuki Nishiya, Yoshimasa Uehara   +7 more
doaj   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

Chromosome Segregation: Seeing Is Believing [PDF]

Current Biology, 2005
For chromosome segregation in mitosis, each centromere directs assembly of a complex, proteinaceous structure - the kinetochore, which connects the chromosome to microtubules of the mitotic spindle. A recent study has provided important new insights into the mechanism by which kinetochores capture spindle microtubules.
openaire   +3 more sources

Depletion or cleavage of cohesin during anaphase differentially affects chromatin structure and segregation

eLife, 2022
Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role determining the ...
Jonay Garcia-Luis, Hélène Bordelet, Agnès Thierry, Romain Koszul, Luis Aragon   +4 more
doaj   +1 more source

Faithful chromosome segregation in Trypanosoma brucei requires a cohort of divergent spindle-associated proteins with distinct functions

Nucleic Acids Research, 2018
Faithful chromosome segregation depends on correct spindle microtubule-kinetochore attachment and requires certain spindle-associated proteins (SAPs) involved in regulating spindle dynamics and chromosome segregation.
Qing Zhou, K. Lee, Y. Kurasawa, Huiqing Hu, T. An, Ziyin Li   +5 more
semanticscholar   +1 more source

Elastic Energy Storage in Biological Materials: Internal Stresses and Their Functionality

Advanced Materials, EarlyView.
Harnessing and storing internally generated elastic energy is a clever strategy by biological materials to perform functions like shape transformation, movement, and predation. This review explores how biological systems manipulate mechanisms like atomic or protein integration into minerals, protein conformational shifts, phase transitions, and osmotic
Shahrouz Amini, Paul Zaslansky, Boaz Pokroy, Peter Fratzl   +3 more
wiley   +1 more source

Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent

Cell Reports, 2016
Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for high-resolution fluorescence imaging (SeeDB2).
Meng-Tsen Ke, Yasuhiro Nakai, Satoshi Fujimoto, Rie Takayama, Shuhei Yoshida, Tomoya S. Kitajima, Makoto Sato, Takeshi Imai   +7 more
doaj   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Spindle asymmetry drives non-Mendelian chromosome segregation

Science, 2017
How selfish genes get their way At the core of Mendelian genetics is the concept that gametes are equally likely to carry either of the two parental copies of a gene.
Takashi Akera, Lukas Chmatal, Emily Trimm, Karren Yang, Chanat Aonbangkhen, D. Chenoweth, C. Janke, R. Schultz, M. Lampson   +8 more
semanticscholar   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source