Results 61 to 70 of about 1,033,685 (362)
Nature Communications, 2023 During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite for ...
Laras Pitayu-Nugroho +7 more
doaj +1 more source
HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]
, 2001 Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson +33 more
core +2 more sources
A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere. [PDF]
PLoS Genetics, 2016 Transcriptional inactivation of the budding yeast centromere has been a widely used tool in studies of chromosome segregation and aneuploidy. In haploid cells when an essential chromosome contains a single conditionally inactivated centromere (GAL-CEN ...
Michael Tsabar +8 more
doaj +1 more source
Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]
, 2014 The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core +2 more sources
Non-random Mis-segregation of Human Chromosomes
Cell Reports, 2018 Summary: A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a ...
Joseph Thomas Worrall +9 more
doaj +1 more source
Nature Communications, 2017 Failure to restart replication forks stalled at genomic regions that are difficult to replicate or contain endogenous DNA lesions is a hallmark of BRCA2 deficiency.
Xianning Lai +7 more
semanticscholar +1 more source
Nuclear Organization and Chromosome Segregation [PDF]
The Plant Cell, 1999 The genetic information underlying plant form and function is contained within the cell nucleus in the form of complex, dynamic DNA–protein structures—the chromosomes. The faithful transmission of these structures during mitosis and meiosis requires extensive chromosome reorganization and ...
A E, Franklin, W Z, Cande
openaire +3 more sources
Protocol for studying topological DNA interactions by purified fission yeast condensin
STAR ProtocolsSummary: To understand the transition from interphase chromatin into well-shaped chromosomes during cell divisions, we need to understand the biochemical activities of the contributing proteins.
Minzhe Tang, Frank Uhlmann
doaj +1 more source
Random Chromosome Partitioning in the Polyploid Bacterium Thermus thermophilus HB27
G3: Genes, Genomes, Genetics, 2019 Little is known about chromosome segregation in polyploid prokaryotes. In this study, whether stringent or variable chromosome segregation occurs in polyploid thermophilic bacterium Thermus thermophilus was analyzed.
Haijuan Li
doaj +1 more source
Spindle asymmetry drives non-Mendelian chromosome segregation
Science, 2017 How selfish genes get their way At the core of Mendelian genetics is the concept that gametes are equally likely to carry either of the two parental copies of a gene.
Takashi Akera +8 more
semanticscholar +1 more source