The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis
Biology, 2017 Mistakes during cell division frequently generate changes in chromosome content, producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal division to generate aneuploid cells.
T. Potapova, G. Gorbsky
semanticscholar +1 more source
Separase prevents genomic instability by controlling replication fork speed [PDF]
, 2017 Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Camerini, Serena +11 more
core +6 more sources
Long-Range Repulsion Between Chromosomes in Mammalian Oocyte Spindles [PDF]
arXiv, 2022 During eukaryotic cell division, a microtubule-based structure called the spindle exerts forces on chromosomes, thereby organizing and segregating them Extensive work demonstrates that the forces acting parallel to the spindle axis, including those responsible for separating sister chromatids, are generated by microtubule polymerization and ...
arxiv
Nucleic Acids Research, 2018 Faithful chromosome segregation depends on correct spindle microtubule-kinetochore attachment and requires certain spindle-associated proteins (SAPs) involved in regulating spindle dynamics and chromosome segregation.
Qing Zhou +5 more
semanticscholar +1 more source
Multimodal effects of small molecule ROCK and LIMK inhibitors on mitosis, and their implication as anti-leukemia agents. [PDF]
PLoS ONE, 2014 Accurate chromosome segregation is vital for cell viability. Many cancer cells show chromosome instability (CIN) due to aberrant expression of the genes involved in chromosome segregation.
Yusuke Oku +7 more
doaj +1 more source
Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation
Journal of Cell Science, 2017 During eukaryote cell division, molecular motors are crucial regulators of microtubule organization, spindle assembly, chromosome segregation and intracellular transport.
Zhen-Yu She, Wan-Xi Yang
semanticscholar +1 more source
Random Chromosome Partitioning in the Polyploid Bacterium Thermus thermophilus HB27
G3: Genes, Genomes, Genetics, 2019 Little is known about chromosome segregation in polyploid prokaryotes. In this study, whether stringent or variable chromosome segregation occurs in polyploid thermophilic bacterium Thermus thermophilus was analyzed.
Haijuan Li
doaj +1 more source
DNA-polymer architecture orchestrates the segregation and spatio-temporal organization of E. coli chromosomes during replication in slow growth [PDF]
arXiv, 2021 The mechanism and driving forces of chromosome segregation in the bacterial cell cycle of E. coli is one of the least understood events in its life cycle. Using principles of entropic repulsion between polymer loops confined in a cylinder, we use Monte carlo simulations to show that the segregation dynamics is spontaneously enhanced by the adoption of ...
arxiv
A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. [PDF]
, 2019 Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress.
Brimacombe, Cedric A +8 more
core +2 more sources
An excess of gene expression divergence on the X chromosome in Drosophila embryos; implications for the faster-X hypothesis [PDF]
PLoS Genetics (2012)8(12):e1003200, 2012 The X chromosome is present as a single copy in the heterogametic sex, and this hemizygosity is expected to drive unusual patterns of evolution on the X relative to the autosomes. For example, the hemizgosity of the X may lead to a lower chromosomal effective population size compared to the autosomes suggesting that the X might be more strongly ...
arxiv +1 more source