Results 161 to 170 of about 5,203 (193)
Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution [PDF]
CellOsteosarcoma is the most common primary cancer of the bone, with a peak incidence in children and young adults. Using multi-region whole-genome sequencing, we find that chromothripsis is an ongoing mutational process, occurring subclonally in 74% of ...
M Fernanda Amary
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Chromothripsis and Kataegis Induced by Telomere Crisis [PDF]
Cell, 2015 Telomere crisis occurs during tumorigenesis when depletion of the telomere reserve leads to frequent telomere fusions. The resulting dicentric chromosomes have been proposed to drive genome instability. Here, we examine the fate of dicentric human chromosomes in telomere crisis.
John Maciejowski +2 more
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Chromothripsis as a pathogenic driver of multiple myeloma
Seminars in Cell and Developmental Biology, 2022Analysis of the genetic basis for multiple myeloma (MM) has informed many of our current concepts of the biology that underlies disease initiation and progression. Studying these events in further detail is predicted to deliver important insights into its pathogenesis, prognosis and treatment.
Ola Landgren +2 more
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Chromothripsis: potential origin in gametogenesis and preimplantation cell divisions. A review
Fertility and Sterility, 2014 International audienceObjective: To review the discovery of chromothripsis and analyze its impact on human reproduction.Design: Database and literature analysis.Setting: University hospital.Patient(s): Carriers of massive and complex chromosomal ...
Franck Pellestor +2 more
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In Brief: Chromothripsis and cancer
The Journal of Pathology, 2013AbstractChromothripsis is a one‐step catastrophic event which plays an important role during cancer development. During chromothripsis, tens to hundreds of genomic rearrangements can occur within localized regions of the genome, and lead to the simultaneous creation of multiple cancer‐driving aberrations.
Alexander W, Wyatt, Colin C, Collins
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Nature Reviews Cancer
Chromothripsis is a mutational phenomenon in which a single catastrophic event generates extensive rearrangements of one or a few chromosomes. This extreme form of genome instability has been detected in 30-50% of cancers. Studies conducted in the past few years have uncovered insights into how chromothripsis arises and deciphered some of the cellular ...
Milena Simovic-Lorenz, Aurélie Ernst
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Chromothripsis is a mutational phenomenon in which a single catastrophic event generates extensive rearrangements of one or a few chromosomes. This extreme form of genome instability has been detected in 30-50% of cancers. Studies conducted in the past few years have uncovered insights into how chromothripsis arises and deciphered some of the cellular ...
Milena Simovic-Lorenz, Aurélie Ernst
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Chromothripsis in Hodgkin lymphoma
Genes, Chromosomes and Cancer, 2013Chromosomal rearrangements are common features of most cancers, where they contribute to deregulated gene expression. Chromothripsis is a recently described oncogenic mechanism whereby small genomic pieces originating from one chromosomal region undergo massive rearrangements in a single step.
Stefan, Nagel +5 more
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Chromothripsis in Human Breast Cancer
Cancer Research, 2020Abstract Chromothripsis is a form of genome instability by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosomes. Widely assumed to be an early event in tumor development, this phenomenon plays a prominent role in tumor onset.
Michiel Bolkestein +17 more
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Detection of Chromothripsis in Plants
2018Chromothripsis, or chromosome shattering, occurs after chromosomes missegregate, are pulverized and subsequently repaired erroneously, leading to highly complex structural rearrangements. In plants, chromothripsis has been observed as a result of mitotic malfunction connected with the incomplete loss of haploid inducer chromosomes during uniparental ...
Isabelle M, Henry +2 more
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Chromothripsis in Lipoblastoma
Journal of Cell Science & Therapy, 2016Lipoblastoma is a benign tumor that often has rearrangements of the 8q11-13 region targeting the PLAG1 gene, which is involved in the process of tumourigenesis. We described a signature of chromotripsis in a thigh lipoblastoma, as first report of chromotripsis in a benign tumor.
Federica Pederiva, Vanessa , Candilera
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