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Chromothripsis

The chromothripsis phenomenon is the first type of chaotic and complex rearrangements discovered since 2011 and now grouped together under the name of chromoanagenesis.Its occurrence has been documented in cancers, congenital diseases as well as in healthy individuals.
Franck, Pellestor, Benjamin, Ganne, Vincent, Gatinois   +2 more
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Chromothripsis in an Early Recurrent Chordoid Meningioma

World Neurosurgery, 2019
Chromothripsis is characterized by a multitude of chromosomal rearrangements during a unique cataclysmic event in a cell life. Disintegration of one or several chromosomes is followed by a chaotic rearrangement of generated fragments. It might play a role in oncogenesis and tumor progression. It is observed in 2%-3% of cancers and is rarely reported in
Cédric, Baltus, Sébastien, Toffoli, Frédéric, London, Paul, Delrée, Claude, Gilliard, Thierry, Gustin   +5 more
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Y chromothripsis?

Nature Cell Biology, 2016
Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non ...
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Chromothripsis in hematologic malignancies

Experimental Hematology
Chromotrypsis, a phenomenon resulting from catastrophic mitotic errors and genomic instability, is defined by the occurrence of multiple DNA double-strand breaks in one or more chromosomes, subsequently subject to error-prone repair mechanisms. This unique process results in extensive rearrangements in the affected chromosomes, leading to loss of tumor
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CRISPR–Cas9 can cause chromothripsis

Nature Genetics, 2021
Genome editing with CRISPR–Cas9 is beginning to be used clinically; promising results to date inspire hope for broad medical impact and mindfulness about safety. A new study shows that when Cas9 cuts its target, a fraction of the time, the target chromosome experiences a breakage process known as chromothripsis, thus prompting efforts to understand the
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Artificial Intelligence and Chromothripsis

Artificial intelligence (AI) emerges as a new alternative in the healthcare domain, particularly in genomics, promising to revolutionize medicine with its various applications. In this chapter, we explore the potential of AI in genetics and research, with a particular focus on its role in the detection and characterization of chromothripsis ...
Davide, Callegarin, Nada, Maaziz, Anne-Laure, Mosca, Nathalie, Marle, Mélodie, Opale, Christophe, Nicolle, Patrick, Callier   +6 more
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Exposing chromothripsis

Nature Structural & Molecular Biology, 2022
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CRISPR and Chromothripsis: Proceed with Caution

The CRISPR Journal, 2021
Stephanie, Mack, I Alasdair, Russell
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Chromothripsis and drug resistance

Nature Genetics, 2021
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Chromothripsis in Uterine Leiomyomas

New England Journal of Medicine, 2013
Miika, Mehine, Eevi, Kaasinen, Lauri A, Aaltonen   +2 more
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