Results 31 to 40 of about 5,203 (193)
Structural variant evolution after telomere crisis
Nature Communications, 2021 Telomere crisis has been shown to induce chromothripsis and breakage fusion bridge (BFB) cycles in vitro. Here, the authors show that telomere crisis generates a much broader spectrum of structural variations, implying that cancers without chromothripsis
Sally M. Dewhurst +8 more
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Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos
Entropy, 2023 During the progression of some cancer cells, the degree of genome instability may increase, leading to genome chaos in populations of malignant cells. While normally chaos is associated with ergodicity, i.e., the state when the time averages of relevant ...
Sergey Shityakov +3 more
doaj +1 more source
De Novo Small Supernumerary Marker Chromosomes Arising From Partial Trisomy Rescue
Frontiers in Genetics, 2020 Small supernumerary marker chromosomes (SMCs) are rare cytogenetic abnormalities. De novo small SMCs, particularly those combined with uniparental disomy (UPD), are assumed to result from incomplete trisomy rescue.
Keiko Matsubara +4 more
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Chromothripsis in lipoblastoma: second reported case with complex PLAG1 rearrangement
Molecular Cytogenetics, 2023 Lipoblastomas (LPBs) are rare benign neoplasms derived from embryonal adipose that occur predominantly in childhood. LPBs typically present with numeric or structural rearrangements of chromosome 8, the majority of which involve the pleomorphic adenoma ...
Joel Lanceta +7 more
doaj +1 more source
Cytogenomic Profile of Uterine Leiomyoma: In Vivo vs. In Vitro Comparison
Biomedicines, 2021 We performed a comparative cytogenomic analysis of cultured and uncultured uterine leiomyoma (UL) samples. The experimental approach included karyotyping, aCGH, verification of the detected chromosomal abnormalities by metaphase and interphase FISH ...
Alla S. Koltsova +19 more
doaj +1 more source
BMC Medical Genomics, 2020 Background Chromothripsis is an event of genomic instability leading to complex chromosomal alterations in cancer. Frequent long-range chromatin interactions between transcription factors (TFs) and targets may promote extensive translocations and copy ...
Chun-Lin Lin +15 more
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Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications
Frontiers in Oncology, 2023 Chemotherapy is widely used to treat patients with cancer. However, resistance to chemotherapeutic drugs remains a major clinical concern. The mechanisms of cancer drug resistance are extremely complex and involve such factors such as genomic instability,
Juanjuan Luo +10 more
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ChromothripsisDB: a curated database of chromothripsis [PDF]
Bioinformatics, 2015 Abstract Summary: Chromothripsis is a single catastrophic event that can lead to massive genomic rearrangements confined to one or a few chromosomes. It provides an alternative paradigm in cancer development and changes the conventional view that cancer develops in a stepwise progression.
Jian Yang, Gaofeng Deng, Haoyang Cai
openaire +2 more sources
Frontiers in Genetics, 2021 Chromoanagenesis is a descriptive term that encompasses classes of catastrophic mutagenic processes that generate localized and complex chromosome rearrangements in both somatic and germline genomes.
Christopher M. Grochowski +16 more
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Cell Reports, 2012 Chromothripsis represents a novel phenomenon in the structural variation landscape of cancer genomes. Here, we analyze the genomes of ten patients with congenital disease who were preselected to carry complex chromosomal rearrangements with more than two
Wigard P. Kloosterman +21 more
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