Results 41 to 50 of about 5,203 (193)
Chromothripsis in cancer cells: An update [PDF]
International Journal of Cancer, 2015 In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous formation of multiple double‐strand ...
Agata, Rode +4 more
openaire +2 more sources
Chromothripsis from DNA damage in micronuclei [PDF]
Nature, 2015 Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes.
Zhang, Cheng-Zhong +7 more
openaire +4 more sources
Molecular Oncology, 2023 Patients with localised, high‐risk gastrointestinal stromal tumours (GIST) benefit from adjuvant imatinib treatment. Still, approximately 40% of patients relapse within 3 years after adjuvant therapy and the clinical and histopathological features ...
Heidi Maria Namløs +7 more
doaj +1 more source
CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI
, 2016 Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously ...
Liu, Shiwei +7 more
core +1 more source
Chromothripsis and progression-free survival in metastatic colorectal cancer [PDF]
, 2017 Metastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic ...
Daneberga, Zanda +6 more
core +1 more source
The Journal of Pathology, EarlyView.Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti +21 more
wiley +1 more source
Supplementary Figure 1 from Chromothripsis in Human Breast Cancer
, 2020 Overall chromothripsis prevalence (DKFZ-HIPO17, WES), link with clinical outcome and chromothripsis 
occurrence per chromosome for each breast cancer ...
Shaymaa Elgaafary (14945289) +17 more
core +1 more source
Chromothripsis in acute myeloid leukemia: Biological features and impact on survival [PDF]
, 2018 Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one or few chromosomes in multiple fragments and consequent random rejoining and repair.
Emanuela Ottaviani +53 more
core +2 more sources
Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer
The FEBS Journal, EarlyView.Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa +2 more
wiley +1 more source
Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model
, 2023 Chromothripsis defines a genetic phenomenon where up to hundreds of clustered chromosomal rearrangements can arise in a single catastrophic event. The phenomenon is associated with cancer and congenital diseases.
Aldo Spanjaard +3 more
core +1 more source