Chromothripsis - Open Access .click

Results 61 to 70 of about 5,203 (193)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, Volume 20, Issue 7, Page 1663-1666, July 2026.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione +1 more
wiley +1 more source

Microhomology at breakpoint junctions is found more frequently than expected by chance in chromothripsis and non-chromothripsis associated breakpoints.

, 2013
The histogram shows theoretical (grey) and observed frequencies of microhomology on validated breakpoint junctions for chromothripsis (orange) and non-chromothripsis cases (yellow).
Gaëlle Pierron (29238) +16 more
core +1 more source

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

, 2023
Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially ...
Jorge Zamora (260484) +499 more
core +1 more source

Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability

Nature Communications
Chromothripsis is a frequent form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or multiple chromosome(s). However, little is known about the heterogeneity of chromothripsis across
Petr Smirnov +25 more
doaj +1 more source

The Landscape of Somatic Copy Number Alterations in Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Somatic copy number alterations (CNAs) play a significant role in the development of this lethal cancer.
Jian Yang, Yi Chen, Hong Luo, Haoyang Cai +3 more
doaj +1 more source

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source

Constitutional chromothripsis involving the critical region of 9q21.13 microdeletion syndrome

, 2015
BACKGROUND: The chromothripsis is a biological phenomenon, first observed in tumors and then rapidly described in congenital disorders. The principle of the chromothripsis process is the occurrence of a local shattering to pieces and rebuilding of ...
CASERTANO, ALBERTO +9 more
core +2 more sources

Real‐world treatment patterns and outcomes in accelerated and blast‐phase myeloproliferative neoplasms: Insights from a large multi‐centre cohort analysis in the United Kingdom

British Journal of Haematology, Volume 209, Issue 1, Page 160-171, July 2026.
Summary This UK‐based retrospective analysis describes real‐world treatment patterns and outcomes in 175 patients with accelerated (AP, n = 69) or blast‐phase (BP, n = 106) ‘Philadelphia‐negative’ myeloproliferative neoplasms (MPN‐AP/BP) diagnosed between 2013 and 2025. Median age at transformation was 71 years.
Alexandros Rampotas +35 more
wiley +1 more source

A Role for Retrotransposons in Chromothripsis [PDF]

, 2018
Chromothripsis is a mutational event driven by tens to hundreds of double-stranded DNA breaks which occur in a single event between a limited number of chromosomes. Following chromosomal shattering, DNA fragments are stitched together in a seemingly random manner resulting in complex genomic rearrangements including sequence shuffling, deletions, and ...
openaire +2 more sources

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, Volume 36, Issue 4, July 2026.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato +15 more
wiley +1 more source

cancer
science
chromoplexy

chromosomal instability
chromoanasynthesis
chromoanagenesis

complex chromosomal rearrangements
micronuclei
multiple myeloma