Results 61 to 70 of about 1,322,182 (207)

The activation of the Notch signaling pathway by UBE2C promotes the proliferation and metastasis of hepatocellular carcinoma

Scientific Reports
UBE2C, a ubiquitin-conjugating enzyme, functions as an oncogene in different types of human cancers. Nonetheless, the exact influence of UBE2C on the development of HCC via regulation of ubiquitination remains uncertain.
Ping Zhan, Yuyan Lu, Jing Lu, Yizhe Cheng, Changhong Luo, Fan Yang, Wenqing Xi, Jinzhu Wang, Xuesong Cen, Fuqiang Wang, Chengrong Xie, Zhenyu Yin   +11 more
doaj   +1 more source

IFN-γ–STAT1–iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity

Frontiers in Immunology, 2017
Autoimmune diseases often induce dysregulated hematopoiesis with altered number and function of hematopoietic stem and progenitor cells (HSPCs). However, there are limited studies on the direct regulation of HSPCs on T cells, which are often detrimental ...
Shu-Han Yang, Shu-Han Yang, Liang Li, Liang Li, Yu-Qing Xie, Yuan Yao, Yuan Yao, Cai-Yue Gao, Cai-Yue Gao, Liang-Huan Liao, Liang-Huan Liao, Hong-Di Ma, M. Eric Gershwin, Zhe-Xiong Lian, Zhe-Xiong Lian, Zhe-Xiong Lian   +15 more
doaj   +1 more source

Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome [PDF]

, 2016
There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabinoids
Ahmed, Lina, Atkin, Stephen L., Coady, Anne-Marie, Dakroury, Youssra, Elshewehy, Abeer M. M., Kilpatrick, Eric S., Sathyapalan, Thozhukat   +6 more
core   +2 more sources

Analysis of different prognoses in two hepatocellular carcinoma patients with pathological complete response after conversion therapy: a case report

Journal of Medical Case Reports
Background Hepatocellular carcinoma is a common lethal malignancy, with most patients diagnosed at an advanced stage, precluding surgical resection. Conversion therapy combining locoregional and systemic treatments has emerged as an effective approach to
Qinliang Fang, Yu Xiong, Yibin Zhang, Fuqiang Wang, Zhenyu Yin, Jianyin Zhou   +5 more
doaj   +1 more source

CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2019
Background CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.
Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guanyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin, Jie Zhang   +10 more
doaj   +1 more source

Atrial natriuretic factor [PDF]

, 1987
The discovery of the first well-defined natriuretic hormone, the Atrial Natriuretic Factor (ANF), has prompted research on its impact on volume regulation in health and disease.
A.L. Gerbes, Ames, Anderson, Anderson, Arendt, Arendt, Arendt, Arendt, Atlas, Ballermann, Ballermann, Barakat, Bichet, Bichet, Biollaz, Bompiani, Bonkovsky, Bourgoignie, Brabant, Bricker, Buckalew, Burghardt, Burnett, Campbell, Chartier, Conn, Cuneo, Currie, De Wardener, DeBold, DeBold, DeWardener, Epstein, Epstein, Epstein, Epstein, Epstein, Fernandez-Cruz, Forssmann, Fyhrquist, G. Paumgartner, Ganger, Gauer, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerzer, Gerzer, Ginés, Goodfriend, Hartshorne, Henry, Jimenez, Jüppner, Kisch, Kramer, Laffi, Lang, Laragh, Maack, Manning, Marin-Grez, Morgan, Naruse, Needleman, Needleman, Nishiuchi, Nozuki, Ogihara, R.M. Arendt, Renner, Richards, Richards, Richards, Riegger, Ring-Larsen, Rosoff, Sagnella, Sagnella, Salerno, Samson, Schafferhans, Shenker, Sherlock, Shimizu, Thibault, Tikkanen, Uehlinger, Valdivieso, Wambach, Weidmann, Wernze, Wilkinson, Wong, Yamaji, Zipser   +99 more
core   +1 more source

Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]

, 2020
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen, Kusumanchi, Praveen, Liangpunsakul, Suthat, Yang, Zhihong, Zhang, Ting   +4 more
core   +1 more source

Acute kidney injury and post-reperfusion syndrome in liver transplantation [PDF]

, 2016
In the past decades liver transplantation (LT) has become the treatment of choice for patients with end stage liver disease (ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors
Evison, Felicity, Ferguson, James, Gunson, Bridget, Mitterhofer, Anna Paola, Muiesan, Paolo, Scalera, Irene, Sharif, Adnan, Tinti, Francesca, Umbro, Ilaria   +8 more
core   +3 more sources

Effects of Botrychium ternatum (Thunb) Sw. On Cytochrome P450 Activities in Rats

Pharmacology Research & Perspectives
Drug interactions commonly occur through the activities of cytochrome P450 (CYP). In this study, we evaluated the effects of the Chinese herbal medicine Botrychium Ternatum (Thunb) Sw. (BT) on six CYP enzymes. Twelve healthy male Sprague–Dawley rats were
Jiange Yao, Liming Hu, Quan Zhou, Abdullah Al Mamun, Shuanghu Wang, Aixia Han   +5 more
doaj   +1 more source

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells

Neoplasia: An International Journal for Oncology Research
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90 % of all cases. ONC201, a member of the imipridone drug family, has shown promising therapeutic potential and a good safety profile in both malignant ...
Jiahao Cao, Fei Cao, Chuanzheng Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao   +6 more
doaj   +1 more source