Results 141 to 145 of about 248,205 (145)

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

Blood, 1999
Despite having several characteristics of naïve B cells, chronic lymphocytic leukemia (CLL) cells have been shown in some cases to have somatically mutated Ig variable region genes, indicating that the cell of origin has passed through the germinal ...
T. Hamblin, Z. Davis, A. Gardiner, D. Oscier, F. Stevenson   +4 more
semanticscholar   +1 more source

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2020
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are characterized by a progressive accumulation of leukemic cells in the peripheral blood, bone marrow, and lymphoid tissues. Treatment of CLL/SLL has evolved significantly in recent
W. Wierda, J. Byrd, J. Abramson, S. Bilgrami, G. Bociek, D. Brander, Jennifer Brown, A. Chanan-Khan, J. Chavez, S. Coutre, R. Davis, C. Fletcher, B. Hill, B. Kahl, M. Kamdar, L. Kaplan, N. Khan, T. Kipps, M. Lim, Shuo Ma, S. Malek, A. Mato, C. Mosse, M. Shadman, T. Siddiqi, D. Stephens, S. Sundaram, Nina Wagner, M. Dwyer, Hema M Sundar   +29 more
semanticscholar   +1 more source

Treatment of Chronic Lymphocytic Leukemia.

New England Journal of Medicine, 2020
Chronic Lymphocytic Leukemia Treatment of CLL, the most common leukemia in the West, has undergone a revolution in the past few years with the development of agents that target signaling kinases an...
J. Burger
semanticscholar   +1 more source

Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial.

Journal of Clinical Oncology, 2018
Purpose Venetoclax is an orally bioavailable B-cell lymphoma 2 inhibitor. US Food and Drug Administration and European Medicines Agency approval for patients with 17p deleted relapsed/refractory chronic lymphocytic leukemia [del(17p) CLL] was based on ...
S. Stilgenbauer, B. Eichhorst, J. Schetelig, P. Hillmen, J. Seymour, S. Coutre, W. Jurczak, S. Mulligan, A. Schuh, S. Assouline, C. Wendtner, A. Roberts, M. Davids, J. Bloehdorn, T. Munir, S. Böttcher, Lang Zhou, A. Salem, Monali Desai, B. Chyla, Jennifer Arzt, S. Y. Kim, M. Verdugo, G. Gordon, M. Hallek, W. Wierda   +25 more
semanticscholar   +1 more source

Chronic Lymphocytic Leukemia

Methods in Molecular Biology, 2019
Sami N. Malek
semanticscholar   +1 more source