Results 171 to 180 of about 122,165 (292)

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Potential impact of parasites in the transmission of chronic wasting disease. [PDF]

Neural Regen Res
Soto P, Morales R.
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Impact of low testing numbers on chronic wasting disease apparent prevalence. [PDF]

Prion
Mori JJ, Rivera NA, Brown WM, Skinner DJ, Schlichting PE, Novakofski JE, Mateus-Pinilla NE.   +6 more
europepmc   +1 more source

28.7 Chronic wasting disease [PDF]

, 2015
openaire   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Spatial and Temporal Patterns of Prion Gene Variation Are Consistent With a Response to Chronic Wasting Disease-Induced Selection in Wild White-Tailed Deer. [PDF]

Ecol Evol
Bubac CM, Russell T, McKenzie D, Ball MC, Pybus MJ, Coltman DW, Cullingham CI.   +6 more
europepmc   +1 more source

Chronic wasting disease in Norway

Bulletin de l'OIE, 2017
K. LANDSVERK, J. JARP, S. HALLDORSDOTTIR
openaire   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Vertical transmission of chronic wasting disease in free-ranging white-tailed deer populations. [PDF]

Sci Rep
Sandoval AM, Nalls AV, McNulty EE, Denkers ND, Trujillo DJ, Olmsted Z, Barton E, Ballard JR, Grove DM, Dennison JS, Stilwell N, Cleveland CA, Crum JM, Ruder MG, Mathiason CK.   +14 more
europepmc   +1 more source