Results 1 to 10 of about 18,861 (207)

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

Journal of Lipid Research, 1994
The participation of hepatic lipase in the initial uptake and processing of chylomicron remnants was studied in the isolated, perfused rat liver. Hepatic lipase activity was either reduced by preperfusion of livers with heparin or inhibited with specific
S Shafi, S E Brady, A Bensadoun, R J Havel   +3 more
doaj   +2 more sources

Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase [PDF]

Journal of Lipid Research, 2005
The LDL receptor and the LDL receptor-related protein (LRP) mediate the removal of chylomicron remnants. The LRP pathway involves sequestration of particles in the space of Disse.
Sung-Joon Lee, Sujata Kadambi, Kenneth C-W. Yu, Christopher David, Salman Azhar, Allen D. Cooper, Sungshin Y. Choi   +6 more
doaj   +2 more sources

Chylomicron/chylomicron remnant turnover in humans: evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants

Journal of Lipid Research, 1997
The size of cholesterol-rich lipoprotein particles is a strong determinant of whether they may be deposited in the arterial wall and by this become potentially atherogenic. This study deals with the in vivo transformation of larger-sized chylomicrons and
F Karpe, T Olivecrona, A Hamsten, M Hultin   +3 more
doaj   +4 more sources

Fatty acid nitroalkenes regulate intestinal lipid absorption [PDF]

Journal of Lipid Research
Fatty acid nitroalkenes (NO2-FA) are tissue-protective and anti-inflammatory endogenous lipid mediators. A unique electrophilic character promotes reversible reactions with protein thiols, influencing key cellular functions. Given their generation during
Francisco J. Schopfer, Lihong Teng, Ahssan Sekandari, Ese S. Ekhator, Alison B. Kohan, Bruce A. Freeman, Marco Fazzari   +6 more
doaj   +2 more sources

A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron triglyceride and retinyl palmitate response in normolipidemic carriers.

Journal of Lipid Research, 1996
An Asn291Ser mutation in exon 6 of the lipoprotein lipase gene (LPL) frequently occurs in Caucasians (2-4%) and results in a partial catalytic defect.
S N Pimstone, S M Clee, S E Gagné, L Miao, H Zhang, E A Stein, M R Hayden   +6 more
doaj   +2 more sources

Glucose-dependent insulinotropic polypeptide stimulates post-absorptive lipid secretion in the intestine [PDF]

Frontiers in Physiology
It is increasingly recognized that the intestine can retain a portion of dietary fats for secretion during the post-absorptive state, which has strong implications in metabolic diseases.
Rong Wang, Muhammad Saad Abdullah Khan, Kundanika Mukherjee, Murooj Ghanem, Changting Xiao   +4 more
doaj   +2 more sources

Resistance of chylomicron and VLDL remnants to post-heparin lipolysis in ApoE-deficient mice: the role of apoE in lipoprotein lipase-mediated lipolysis in vivo and in vitro

Journal of Lipid Research, 1998
The interaction of lipoprotein lipase (LPL) with triglyceride-rich lipoproteins is governed by a number of factors, such as apolipoprotein (apo) C-II. The role of apoE in lipolysis is controversial.
Eva Zsigmond, Yasu Fuke, Lan Li, Kunihisa Kobayashi, Lawrence Chan   +4 more
doaj   +2 more sources

Extracellular Vesicles From Chylomicron-Treated Endothelial Cells Drive Macrophage Inflammation. [PDF]

Arterioscler Thromb Vasc Biol
Tilp A, Nasias D, Carley AL, Park MY, Mooring A, Tirumalasetty MB, Abumrad NA, Wang Y, Miao QR, Lewandowski ED, Alemán JO, Goldberg IJ, Cabodevilla AG.   +12 more
europepmc   +3 more sources

Impaired intestinal free fatty acid transport followed by chylomicron malformation, not pancreatic insufficiency, cause metabolic defects in cystic fibrosis. [PDF]

J Lipid Res
Teng L, Dedousis N, Adeshirlarijaney A, Kanshana JS, Liu M, Hodges CA, Kohan AB.   +6 more
europepmc   +3 more sources

Evidence that chylomicron remnants and beta-VLDL are transported by the same receptor pathway in J774 murine macrophage-derived cells.

Journal of Lipid Research, 1990
To characterize lipoprotein uptake by macrophages, we studied J774 murine macrophage-derived cells. Uptake of 125I-labeled beta-VLDL and 125I-labeled chylomicron remnants was saturable, specific, and of high affinity.
J L Ellsworth, A D Cooper, F B Kraemer
doaj   +1 more source