Results 41 to 50 of about 10,514 (223)

Low and high responders to pharmacological doses of β-carotene: proportion in the population, mechanisms involved and consequences on β-carotene metabolism

Journal of Lipid Research, 1998
The aim of this study was to assess the interindividual variability of chylomicron β-carotene response to a pharmacological load of β-carotene in the population, to identify the mechanisms responsible for this variability, and to evaluate its ...
Patrick Borel, Pascal Grolier, Nadia Mekki, Yves Boirie, Yvanne Rochette, Brigitte Le Roy, Marie C. Alexandre-Gouabau, Denis Lairon, Véronique Azais-Braesco   +8 more
doaj  

Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2573-2583, May 2025.
Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention and management of chronic kidney disease (CKD). Remnant cholesterol (RC), a lipoprotein with an established association with cardiovascular risk, has been investigated in the context of CKD.
Paschalis Karakasis, Dimitrios Patoulias, Manfredi Rizzo, Nikolaos Fragakis, Christos S. Mantzoros   +4 more
wiley   +1 more source

Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature

Advanced Science, Volume 12, Issue 14, April 10, 2025.
A novel structure‐function relationship is identified for lung‐targeting ionizable lipids with nonpermanent charges. These lipids feature N‐methyl and secondary amine groups in their heads and three tails derived from epoxyalkanes, demonstrating superior pulmonary selectivity and efficiency.
Xiaoyan He, Runyuan Wang, Yan Cao, Yan Ding, Yan Chang, Haoru Dong, Rong Xie, Guisheng Zhong, Huiying Yang, Jianfeng Li   +9 more
wiley   +1 more source

Intestinal basolateral lipid substrate transport is linked to chylomicron secretion and is regulated by apoC-III

Journal of Lipid Research, 2019
Chylomicron metabolism is critical for determining plasma levels of triacylglycerols (TAGs) and cholesterol, both of which are risk factors for CVD.
Diana Li, Cayla N. Rodia, Zania K. Johnson, Minkyung Bae, Angelika Muter, Amy E. Heussinger, Nicholas Tambini, Austin M. Longo, Hongli Dong, Ji-Young Lee, Alison B. Kohan   +10 more
doaj  

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase

Journal of Lipid Research, 2005
The LDL receptor and the LDL receptor-related protein (LRP) mediate the removal of chylomicron remnants. The LRP pathway involves sequestration of particles in the space of Disse.
Sung-Joon Lee, Sujata Kadambi, Kenneth C-W. Yu, Christopher David, Salman Azhar, Allen D. Cooper, Sungshin Y. Choi   +6 more
doaj  

Chemical Toxicants Used for Food Preservation in Africa. Is it a Case of Ignorance or Food Fraud? A Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background and Aims This review examined the use of chemical preservatives in food preservation and the food fraud risks associated with its misuse in Africa. In Africa, there is growing reliance on the use of synthetic chemical preservation such as benzoates, nitrates or sorbates to preserve foods to improve the storage life of the foods ...
Nnabueze Darlington Nnaji, Helen Onyeaka, Kingsley Tochukwu Ughamba, Chukwuebuka Maxwell Ononugbo, Chinasa Valerie Olovo, Ifeanyi Michael Mazi   +5 more
wiley   +1 more source

Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E

Journal of Lipid Research, 2000
Apolipoprotein E (apoE) is a ligand for the low density lipoprotein receptor (LDLR) and the low density lipoprotein receptor-related protein (LRP). The aim of the present study was to clarify the role of hepatically localized apoE in the rapid initial ...
Kenneth C-W. Yu, Yuan Jiang, Wei Chen, Allen D. Cooper   +3 more
doaj  

Role of the Gut in Diabetic Dyslipidemia

Frontiers in Endocrinology, 2020
Type 2 diabetes (T2D) is associated with increased risk of cardiovascular disease (CVD). In insulin resistant states such as the metabolic syndrome, overproduction and impaired clearance of liver-derived very-low-density lipoproteins and gut-derived ...
Priska Stahel, Changting Xiao, Avital Nahmias, Gary F. Lewis   +3 more
doaj   +1 more source

Binding of Selected Ligands to Human Protein Disulfide Isomerase and Microsomal Triglyceride Transfer Protein Complex and the Associated Conformational Changes: A Computational Molecular Modelling Study

ChemistryOpen, Volume 14, Issue 4, April 2025.
The interactions of MTP, MTPα and MTPβ (PDI) with three representative small‐molecule ligands are investigated using computational structural and chemical analysis to characterize the binding site structures, the binding strength, the key residues involved, and the conformational changes.
Yong Xiao Yang, Peng Li, Bao Ting Zhu
wiley   +1 more source