Results 21 to 30 of about 118,118 (316)

Impurities in amyloid studies: The power of automated model building within a cautionary tale for structural biologists. [PDF]

Protein Sci
Abstract The purity of protein samples of biological origin is often difficult to ascertain, leading the naïve or optimistic scientist to underestimate contaminants in their research. Even after extensive purification, protein samples can contain nucleic acids, truncated degradation products, or other protein contaminants. While in many cases, and when
Rhyner D, Frey L, Zhou J, Kwiatkowski W, Mezzenga R, Riek R, Greenwald J.   +6 more
europepmc   +2 more sources

Efficacy of chymotrypsin in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis

The Egyptian Journal of Internal Medicine, 2019
Background Pancreatitis is common after endoscopic retrograde cholangiopancreatography (ERCP). Aim To assess the pharmacological effect of diclofenac, allopurinol and chymotrypsin in the prevention of postendoscopic retrograde cholangiopancreatography ...
Ahmed A Attia, Esam A Elshimi, Tamer R Fouad, El-Sayed A Ibrahim, Wael M Abdel-Razek   +4 more
doaj   +1 more source

Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice.

Gastroenterology, 2018
Intrapancreatic activation of the digestive proteases trypsin and chymotrypsin is an early event in the development of pancreatitis. Human genetic studies indicate that chymotrypsin controls trypsin activity via degradation, but there is no evidence of ...
Zsanett Jancsó, E. Hegyi, M. Sahin-Tóth   +2 more
semanticscholar   +1 more source

Chymotrypsin in Cancer

Experimental Biology and Medicine, 1949
SummaryParenteral injections of chymo-trypsin had no effect on the course of 101 cases of neoplastic disease in man.
Michael B. Shimkin, Howard R. Bierman
openaire   +3 more sources

Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. [PDF]

, 2018
The cardiac Na+-Ca2+ exchanger (NCX) plays a critical role in the heart by extruding Ca2+ after each contraction and thus regulates cardiac contractility.
Goldhaber, Joshua I, John, Scott, Kim, Brian, Olcese, Riccardo, Ottolia, Michela   +4 more
core   +1 more source

Comparative analysis of low-frequency vibrational spectra of native and denatured proteins [PDF]

Известия Саратовского университета. Новая серия: Физика
Background and Objectives: Changes in the secondary and tertiary structures of protein molecules during thermal denaturation lead to changes in their vibrational spectra.
Mankova, Anna A., Brandt, Nikolay Nikolaevich, Chikishev, Andrey Yu.   +2 more
doaj   +1 more source

Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation

British Journal of Cancer, 2017
Background:Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown.
Mikko T. Nieminen, D. Listyarifah, J. Hagström, C. Haglund, D. Grenier, D. Nordström, V. Uitto, Marcela Hernández, T. Yucel-Lindberg, T. Tervahartiala, M. Ainola, T. Sorsa   +11 more
semanticscholar   +1 more source

Primary structure of potato Kunitz-type serine proteinase inhibitor [PDF]

, 2000
The serine proteinase inhibitor (PSPI-51) isolated from potato tubers (Solanum tuberosum L,) comprises two protein species with pi 5.2 and 6.3, denoted as PSPI-21-5.2 and PSPI-21-6.3, respectively.
Mentele, Reinhard, Mosolov, Vladimir V., Revina, Tatyana A., Valueva, Tatyana A.   +3 more
core   +1 more source

Safety evaluation of a food enzyme containing trypsin, chymotrypsin, elastase and carboxypeptidase from porcine pancreas

EFSA Journal, 2021
The food enzyme is a protease complex, containing trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1), pancreatic elastase (EC 3.4.21.36) and carboxypeptidase B (EC 3.4.17.2), obtained from porcine pancreas by Neova Technologies Inc.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Claude Lambré, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Ursula Gundert‐Remy, Lieve Herman, Dominique Turck, Karl‐Heinz Engel, Margarita Aguilera‐Gómez, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Yi Liu, Joaquim Maia, Sandra Rainieri, Andrew Chesson   +28 more
doaj   +1 more source

Discovery of Specific Nonpeptide Probe for Chymotrypsin via Molecular Docking-Based Virtual Screening and the Application.

ACS Applied Bio Materials, 2018
Chymotrypsin is a proteolytic enzyme associated with numerous biological processes. Moreover, it has been reported to be significantly involved in pancreatic diseases.
Hao Xiong, Rong-Rong Li, Shi-Yu Liu, Feng-Xu Wu, Wenchao Yang, Guangfu Yang   +5 more
semanticscholar   +1 more source