Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
core +2 more sources
Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells [PDF]
, 2018 Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression.
Acconcia +111 more
core +2 more sources
VIP contribution to the decidualization program: regulatory T cell recruitment [PDF]
, 2014 During early pregnancy, the human uterus undergoes profound tissue remodeling characterized by leukocyte invasion and production of proinflammatory cytokines, followed by tissue repair and tolerance maintenance induction.
Agüero, Mariana +5 more
core +1 more source
Dr. Bruno Librado Bello Gutiérrez: excelente profesor universitario
Revista Habanera de Ciencias Médicas, 2022 Se enaltecen los aspectos y servicios científicos más importantes de la vida del prestigioso doctor y su valiosa preparación como profesor, investigador, salubrista e higienista, así también como paradigma militar en situaciones excepcionales y desastres.
Maritza Cardosa Samón +1 more
doaj
Complete Genome Sequences of Lactobacillus Phages J-1 and PL-1 [PDF]
, 2014 Lactobacillus phages J-1 and PL-1 were isolated during the 1960s from abnormal fermentations of Yakult. The genomes are almost identical, but PL-1 has a deletion in the genetic switch region and also differs in a gene coding for a putative tail protein ...
Dieterle, María Eugenia +4 more
core +1 more source
Could an increase in education raise income inequality? : evidence for Latin America [PDF]
, 2014 This paper explores the direct effect of an education expansion on the level of earnings inequality by carrying out microsimulations for most Latin American countries.
Battistón, Diego Ezequiel +2 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Enseñanza de las Ciencias en Entornos Tecnológicos: un curso para profesores
Educación Química, 2018 El propósito del curso Enseñanza de las Ciencias en Entornos Tecnológicos es dotar a los profesores de herramientas informáticas y de comunicación con el fin de que puedan incorporarlas de inmediato a su labor docente y sean de fácil acceso para sus ...
Jorge R. Martínez Peniche +1 more
doaj +1 more source
Genes of different catabolic pathways are coordinately regulated by Dal81 in Saccharomyces cerevisiae [PDF]
, 2015 Yeast can use a wide variety of nitrogen compounds. However, the ability to synthesize enzymes and permeases for catabolism of poor nitrogen sources is limited in the presence of a rich one.
Bermudez Moretti, Mariana +2 more
core +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source