Results 131 to 140 of about 693 (156)
Some of the next articles are maybe not open access.
Total Synthesis of Ciguatoxin and 51-HydroxyCTX3C
Journal of the American Chemical Society, 2006Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers with the 13 ether rings ranging from five- to nine-membered. In this paper, we describe the total synthesis of the two most toxic members of the ciguatoxin family, ciguatoxin 1 and 51-hydroxyCTX3C 2, based on a unified synthetic strategy.
Masayuki, Inoue +9 more
openaire +2 more sources
A radioimmunoassay for the detection of ciguatoxin
Toxicon, 1977Abstract A practical, sensitive, simple and relatively specific radioimmunoassay test for the assay of ciguatoxin directly from natural sources has been developed. The radioimmunoassay test has been utilized to distinguish the toxic fishes in human ciguatera poisoning outbreaks from the nontoxic fishes.
Y, Hokama, A H, Banner, D B, Boylan
openaire +2 more sources
Ciguatoxin: developing the methodology for total synthesis
Natural Product Reports, 2010Covering: up to 2009 The ciguatoxins are sodium channel toxins from the marine dinoflagellate Gambierdiscus toxicus, isolated in 1984. In this review, we summarize the principal concepts and recently developed methodologies for the synthesis of the ciguatoxins, including C–C bond formation by silylacetylene and cobalt-mediated cyclization.
Minoru, Isobe, Akinari, Hamajima
openaire +2 more sources
An investigation into ciguatoxin bioaccumulation in sharks
Toxicon, 2016Ciguatoxins (CTXs) produced by benthic Gambierdiscus dinoflagellates, readily biotransform and bioaccumulate in food chains ultimately bioconcentrating in high-order, carnivorous marine species. Certain shark species, often feeding at, or near the top of the food-chain have the ability to bioaccumulate a suite of toxins, from both anthropogenic and ...
Lauren Meyer +3 more
openaire +3 more sources
Multiple ciguatoxins in the flesh of fish
Toxicon, 1992Most cases of ciguatera (fish poisoning) result from consumption of the flesh of fishes contaminated with ciguatoxin(s); however, the relatively low toxicity of ciguateric fish flesh has hindered attempts to identify these ciguatoxin(s). Utilising high performance liquid chromatography, mass spectroscopy and mouse bioassay signs we have determined that
Lewis, Richard J., Sellin, Michelle
openaire +3 more sources
Isolation and characterisation of Indian Ocean ciguatoxin
Toxicon, 2002We report the isolation and initial characterisation of Indian Ocean ciguatoxin (I-CTX) present in toxic lipid soluble extracts isolated from ciguateric fishes collected off the Republic of Mauritius in the Indian Ocean. Following i.p. injection of this extract, mice displayed symptoms that were similar, though not identical, to those produced by ...
Hamilton, B. +4 more
openaire +3 more sources
[Ciguatoxin and edible reef fishes].
Bulletin de la Societe de pathologie exotique et de ses filiales, 1976Referring to the various human and animal clinical response to consumption of reef fish, the authors precise the importance of ingested dose and the role of cumulative effects. They point out the arbitrary character of distinguishing poisonous and edible fish of the same species. At the light of these data they find ciguatoxin in edible fish from known
R, Bagnis, J P, Vernoux
openaire +1 more source
Preliminary results towards ciguatoxin immunodetection.
Bulletin de la Societe de pathologie exotique (1990), 1993Due to the lack of purified ciguatoxin (CTX), monensin was used as a model for developing an enzyme immunoassay to detect CTX. Specific antibodies directed against monensin have been produced in rabbits and mice using a monensin-protein immunogen obtained in bulk quantities.
S, Pauillac +3 more
openaire +1 more source