Results 41 to 50 of about 3,206 (156)

Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
Heteroatom‐containing plastics such as polyurethanes and nylons are produced at scale yet remain largely unrecycled. Biocatalysts offer a promising route to depolymerization under mild conditions. Here, we present a screening platform for the discovery of novel polyurethane‐ and nylon‐degrading enzymes from environmental samples and demonstrate ...
Malthe Kjær Bendtsen, Andreas Møllebjerg, Samuel Peña‐Díaz, Rosie Graham, Nicolai Claus Petersen, Bjørk Nolsøe Isaksen, Mathias Carstensen, Martin B. Johansen, Andreas Sommerfeldt, Allan R. Petersen, Iddi Khamisi Chuma, Cecilie Ryberg, Thomas Rea Wittenborn, Virginia Gichuru, Huabing Wang, Carsten Scavenius, Alexander Sandahl, Daniel E. Otzen   +17 more
wiley   +2 more sources

Effect of DC-CIK cell on the proliferation, apoptosis and differentiation of leukemia cells

Asian Pacific Journal of Tropical Medicine, 2014
To observe the effect of co-culture cytokine-induced killer cells (CIK) and homologous dendritic cells (DC) on the proliferative activity and phenotype change of the DC-CIK cell and the cell killing activity of leukemia HL-60.50 mL cord blood sample was obtained from infants delivered by full term healthy woman and the cord blood mononuclear cells were
Qu, Hui-Qing, Zhou, Xiao-Sheng, Zhou, Xiao-Long, Wang, Jian   +3 more
openaire   +2 more sources

The possible molecular regulation mechanism of CIK cells inhibiting the proliferation of Human Lung Adenocarcinoma NCL-H157 Cells

Open Medicine, 2016
Cytokine-induced killer (CIK) cells were isolated and proliferation from human peripheral blood and cultured in appropriate growth medium. The biological characteristics of CIK cells were further determined by the characterization of surface markers by ...
Li Dengrui, Yang Yonghui, Gao Li, Guo Sumin, Hui Li, Zhu Guiyun, Hou Hongwei, Wu Shucai   +7 more
doaj   +1 more source

Combination therapy of irreversible electroporation and cytokine-induced killer cells for treating mice bearing panc02 pancreatic-cancer xenografts

Biochemistry and Biophysics Reports, 2023
The current study aimed to investigate the antitumor effects and potent mechanism of cytokine-induced killer (CIK) cells combined with irreversible electroporation (IRE) via Panc02 cell-bearing mouse model in vivo.
Baohua Wang, Huiyang Wang, Lan Yue, Qiang Chen, Junjie Dong, Tian'an Jiang   +5 more
doaj   +1 more source

Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells

Clinical and Developmental Immunology, 2012
Adoptive therapy of malignant diseases with cytokine-induced killer (CIK) cells showed promise in a number of trials; the activation of CIK cells from cancer patients towards their autologous cancer cells still needs to be improved.
Claudia Schlimper, Andreas A. Hombach, Hinrich Abken, Ingo G. H. Schmidt-Wolf   +3 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells

Genetics and Molecular Research, 2015
We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells.
J Z, Mei, G J, Liu, X J, Zhang, J Z, Zhao, R T, Feng   +4 more
openaire   +2 more sources

Cytokine-induced killer (CIK) cells inhibit Plasmodium falciparum parasitemia through cytolytic effector activity in vitro

Immunobiology
Cytokine-induced killer (CIK) cells, with dual traits resembling natural killer (NK) and T cells, have shown a promising clinical efficacy against cancer in clinical application leading to licensing of CIK cells in many countries.
Rohulla Vaseq, Berthila Ferkamchwi, Hans Weiher, Veronika Lukacs-Kornek, Nahid Mahleqa, Marc P. Hübner, Amit Sharma, Ingo G.H. Schmidt-Wolf   +7 more
doaj   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

The Evolving Role of 21st Century Municipal Financial Advisors

Public Budgeting &Finance, EarlyView.
ABSTRACT We describe the evolution of the market for municipal financial advice since the year 2000 and present new empirical facts. Using SEC municipal advisor filings, we show that the number of operating advisors has decreased over time. We document that withdrawals—either exits, reorganizations, or mergers—are concentrated among smaller firms and ...
Daniel G. Garrett, Baridhi Malakar
wiley   +1 more source