Results 31 to 40 of about 3,206 (156)

CD300LG improves the cytotoxic activity of CIK

Central European Journal of Immunology, 2017
To investigate the effect of CD300LG-γ induction on the cytotoxic activity of CIK. Eukaryotic expression plasmid hCD300LG-γ/pEGFP-C3, which can express human CD300LG-γ, was constructed and transfected into CHO cells by lipofectamine.
Qiuyue Wang, Yuqing Liu, Ying Chen, Ke Wang, Wensheng Xie, Dapeng Wei, Lijuan Hu   +6 more
doaj   +1 more source

MMP9-Associated Tumor Stem Cells, CCL1-Silenced Dendritic Cells, and Cytokine-Induced Killer Cells Have a Remarkable Therapeutic Efficacy for Acute Myeloid Leukemia by Activating T Cells

Stem Cells International, 2023
Purpose. Dendritic cells (DC) are specialized antigen-presenting cells, and cytokine-induced killer (CIK) cells have a specific killing activity to a variety of tumors.
Min Dong, Guozhen Zhang, Jie Meng, Biou Liu, Duanfeng Jiang, Feng Liu   +5 more
doaj   +1 more source

ERBB2-CAR-Engineered Cytokine-Induced Killer Cells Exhibit Both CAR-Mediated and Innate Immunity Against High-Risk Rhabdomyosarcoma

Frontiers in Immunology, 2020
High-risk rhabdomyosarcoma (RMS) occurring in childhood to young adulthood is associated with a poor prognosis; especially children above the age of 10 with advanced stage alveolar RMS still succumb to the disease within a median of 2 years.
Michael Merker, Michael Merker, Michael Merker, Juliane Wagner, Hermann Kreyenberg, Catrin Heim, Laura M. Moser, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Halvard Bonig, Halvard Bonig, Zoltán Ivics, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Thomas Klingebiel, Thomas Klingebiel, Thomas Klingebiel, Peter Bader, Peter Bader, Peter Bader, Eva Rettinger, Eva Rettinger, Eva Rettinger   +24 more
doaj   +1 more source

Combined therapy with cytokine-induced killer cells and oncolytic adenovirus expressing IL-12 induce enhanced antitumor activity in liver tumor model. [PDF]

PLoS ONE, 2012
Both adoptive immunotherapy and gene therapy hold a great promise for treatment of malignancies. However, these strategies exhibit limited anti-tumor activity, when they are used alone.
Zhi Yang, Qianzhen Zhang, Ke Xu, Juanjuan Shan, Junjie Shen, Limei Liu, Yanmin Xu, Feng Xia, Ping Bie, Xia Zhang, Youhong Cui, Xiu-Wu Bian, Cheng Qian   +12 more
doaj   +1 more source

Autologous CIK Cell Immunotherapy in Patients with Renal Cell Carcinoma after Radical Nephrectomy [PDF]

Clinical and Developmental Immunology, 2013
Objective. To evaluate the efficacy of autologous cytokine-induced killer (CIK) cells in patients with renal cell carcinoma (RCC).Methods. 20 patients diagnosed with TNM stage I or II RCC were randomly divided into two groups, a CIK cell treatment group and a control group.
Yajing Zhang, Jin Wang, Yao Wang, Xue-Chun Lu, Hui Fan, Yang Liu, Yan Zhang, Kai-Chao Feng, Wen-Ying Zhang, Mei-Xia Chen, Xiaobing Fu, Wei-Dong Han   +11 more
openaire   +3 more sources

30 years of CIK cell therapy: recapitulating the key breakthroughs and future perspective [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
AbstractEmerging evidence from the numerous clinical trials involving cytokine-induced killer (CIK) cell therapy suggests that its optimization in combination with other contemporary cancer therapies in a complementary manner (rather than as competition) will be a key to combat cancer.
Amit Sharma, Ingo G. H. Schmidt-Wolf
openaire   +3 more sources

Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells

Clinical and Developmental Immunology, 2011
Previous reports have suggested that treatment with cytokine-induced killer (CIK) cells may benefit patients with various types of tumor. The aim of this study was to evaluate the antitumor effects of CIK cells against the colorectal cancer line SW1116 ...
Yao Wang, Hanren Dai, Hong Li, Haiyan Lv, Tao Wang, Xiaobing Fu, Weidong Han   +6 more
doaj   +1 more source

How can Cytokine-induced killer cells overcome CAR-T cell limits

Frontiers in Immunology, 2023
The successful treatment of patients affected by B-cell malignancies with Chimeric Antigen Receptor (CAR)-T cells represented a breakthrough in the field of adoptive cell therapy (ACT).
Elisa Cappuzzello, Emilia Vigolo, Giulia D’Accardio, Giuseppe Astori, Antonio Rosato, Antonio Rosato, Roberta Sommaggio, Roberta Sommaggio   +7 more
doaj   +1 more source

Inhibition of human gastric cancer growth by cytokine-induced killer cells plus chemotherapy with or without cadonilimab in a mouse xenograft tumor model

Frontiers in Immunology
BackgroundCytokine-induced killer (CIK) cell therapy has shown potent antitumor cytotoxicity. To date, no study has evaluated the efficacy and safety of combining CIK cell therapy with chemotherapy, with or without the immune checkpoint inhibitor (ICI ...
Wenwei Yang, Jingwei Liu, Tiantian Hou, Xu Lu, Lin Yang   +4 more
doaj   +1 more source

Dendritic cells decreased the concomitant expanded Tregs and Tregs related IL-35 in cytokine-induced killer cells and increased their cytotoxicity against leukemia cells.

PLoS ONE, 2014
Regulatory T cells (Tregs) are potent immunosuppressive cells and essential for inducing immune tolerance. Recent studies have reported that Tregs and Tregs related cytokines can inhibit the antitumor activity of cytokine-induced killer (CIK) cells, but ...
Ying Pan, Qianshan Tao, Huiping Wang, Shudao Xiong, Rui Zhang, Tianping Chen, Lili Tao, Zhimin Zhai   +7 more
doaj   +1 more source