Results 21 to 30 of about 4,425,847 (185)

[Researche advances on CIK cells and their clinical use in lung cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2011
As the leading cause of cancer-related death among human beings, lung cancer seriously threats peoples' health all over the world. Cytokine-induced killer cells (CIK) is a new kind of adaptive immune cells characterized by its dramatic proliferation ability and cytotoxicity, non-major histocompatibility antigens (MHC) restriction and low side effects ...
Hu LUO, Xiangdong ZHOU
openaire   +4 more sources

Human CIK Cells Loaded with Gold Nanoprisms as Theranostic Platform for Targeted Photoacoustic Imaging and Enhanced Immuno-Photothermal Combined Therapy

Nano Biomedicine and Engineering, 2016
How to enhance the therapeutic efficacy of human cytokine induced killers cell (CIK) has become a great challenge. Herein, we report for the first time that human CIK cells loaded with gold nanoprisms were successfully used for targeted photoacoustic ...
Jingjing Zhang, Fangfang Xia, Yao Yang, Caixia Yue, Chunlei Zhang, Yuming Yang, Lijun Ma, Gabriel Alfranca, Yanlei Liu, Yafei Hou, Weilin Jin, Jian Ni, Jesus Martinez de la Fuente, Daxiang Cui   +13 more
doaj   +2 more sources

Dendritic cells decreased the concomitant expanded Tregs and Tregs related IL-35 in cytokine-induced killer cells and increased their cytotoxicity against leukemia cells.

PLoS ONE, 2014
Regulatory T cells (Tregs) are potent immunosuppressive cells and essential for inducing immune tolerance. Recent studies have reported that Tregs and Tregs related cytokines can inhibit the antitumor activity of cytokine-induced killer (CIK) cells, but ...
Ying Pan, Qianshan Tao, Huiping Wang, Shudao Xiong, Rui Zhang, Tianping Chen, Lili Tao, Zhimin Zhai   +7 more
doaj   +2 more sources

CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer

Cell Death and Disease, 2022
Herein, Liu and colleagues show that CD4+ T cells in cytokine-induced killer (CIK) cells are required to enhance the clinical efficacy of CIK therapy. In addition, CD4+ T cells help via IL-17A production is critical to restoring the function of CD8+/CD3 ...
Shaochuan Liu, Yuan Meng, Liang Liu, Yingge Lv, Wenwen Yu, Ting Liu, Limei Wang, Di Mu, Qiuru Zhou, Min Liu, Yulin Ren, Dong Zhang, Baihui Li, Qian Sun, Xiubao Ren   +14 more
doaj   +3 more sources

Cell-based immunotherapy with cytokine-induced killer (CIK) cells: From preparation and testing to clinical application

Human Vaccines & Immunotherapeutics, 2017
Cell-based immunotherapy holds promise in the quest for the treatment of cancer, having potential synergy with surgery, chemotherapy and radiotherapy.
Yiming Meng, Zhifu Yu, Yefeng Wu, Tianzhao Du, Shi Chen, Fanjuan Meng, Nan Su, Yushu Ma, Xiaoxi Li, Sulan Sun, Guirong Zhang   +10 more
doaj   +2 more sources

CIK Cells and HDAC Inhibitors in Multiple Myeloma. [PDF]

Int J Mol Sci, 2017
Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4–5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a ...
Stephan D, Weiher H, Schmidt-Wolf IGH.
europepmc   +5 more sources

Cytokine-induced killer (CIK) cells, successes and challenges: report on the first international conference dedicated to the clinical translation of this unique adoptive cell immunotherapy. [PDF]

Cancer Immunol Immunother
On August 30, 2023, experts from Germany and abroad met to discuss the successes and challenges of cytokine-induced killer cell (CIK) therapy, that recently celebrated its 30th anniversary providing treatment for cancer. This first virtual conference was
Sharma A, Ren X, Rosato A, Sangiolo D, Wang Z, Tettamanti S, Zhang Y, Rettinger E, Fenix KA, Sommaggio R, Cappuzzello E, Schmidt-Wolf IGH.   +11 more
europepmc   +2 more sources

A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic Cancer Cells. [PDF]

Int J Mol Sci, 2022
Despite numerous studies conducted over the past decade, the exact role of the cannabinoid system in cancer development remains unclear. Though research has focused on two cannabinoid receptors (CB1, CB2) activated by most cannabinoids, CB2 holds greater
Garofano F, Sharma A, Abken H, Gonzalez-Carmona MA, Schmidt-Wolf IGH.   +4 more
europepmc   +2 more sources

Targeting CD33 in Chemoresistant AML Patient-Derived Xenografts by CAR-CIK Cells Modified with an Improved SB Transposon System. [PDF]

Mol Ther, 2020
The successful implementation of chimeric antigen receptor (CAR)-T cell therapy in the clinical context of B cell malignancies has paved the way for further development in the more critical setting of acute myeloid leukemia (AML).
Rotiroti MC, Buracchi C, Arcangeli S, Galimberti S, Valsecchi MG, Perriello VM, Rasko T, Alberti G, Magnani CF, Cappuzzello C, Lundberg F, Pande A, Dastoli G, Introna M, Serafini M, Biagi E, Izsvák Z, Biondi A, Tettamanti S.   +18 more
europepmc   +2 more sources

Optimizing tumor-associated antigen-stimulated autologous dendritic cell and cytokine-induced killer cell coculture to enhance cytotoxicity for cancer immunotherapy in manufacturing

BMC Immunology, 2023
Background Dendritic Cell Cytokine-induced killer cell (DC-CIK) coculture treatment in cancer immunotherapy has been shown to be effective. However, the cost of DC- CIK therapy is prohibitive for many patients, and the lack of standard manufacturing ...
Yi-Yen Lee, Shao-Ciao Luo, Chung-Hsin Lee, Chien-Lun Tang, Chiung-Chyi Shen, Wen-Yu Cheng, Yi-Chin Yang, Meng-Yin Yang, Chun-Ming Yen   +8 more
doaj   +1 more source