Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma [PDF]
Scientific ReportsDespite the favorable effects of immunotherapies in multiple types of cancers, its complete success in CNS malignancies remains challenging. Recently, a successful clinical trial of cytokine-induced killer (CIK) cell immunotherapy in patients with ...
Annika Simone Lück +6 more
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Improving Clinical Manufacturing of IL-15 Activated Cytokine-Induced Killer (CIK) Cells [PDF]
Frontiers in Immunology, 2019 Cytokine-induced killer (CIK) cells are an immunotherapeutic approach to combat relapse following allogeneic hematopoietic stem cell transplantation (HSCT) in acute leukemia or myelodysplastic syndrome (MDS) patients. Prompt and sequential administration
Melanie Bremm +13 more
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Anti-CD40 predominates over anti-CTLA-4 to provide enhanced antitumor response of DC-CIK cells in renal cell carcinoma [PDF]
Frontiers in Immunology, 2022 Cytokine-induced killer cells (CIK) in combination with dendritic cells (DCs) have shown favorable outcomes in renal cell carcinoma (RCC), yet some patients exhibit recurrence or no response to this therapy.
Ying Zhang +7 more
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Cytokine-Induced Killer (CIK) Cells, In Vitro Expanded under Good Manufacturing Process (GMP) Conditions, Remain Stable over Time after Cryopreservation [PDF]
Pharmaceuticals, 2020 Cytokine-induced killer (CIK) cells are advanced therapy medicinal products, so their production and freezing process has to be validated before their clinical use, to verify their stability as a drug formulation according to the good manufacturing ...
Katia Mareschi +10 more
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An Exploratory in vitro Study of Cytotoxicity and Cytokine Profiling of Cytokine-Induced Killer (CIK) Cells Against HCT-15 Colorectal Cancer (CRC) Cells [PDF]
ImmunoTargets and TherapySze-Piaw Chin,1,2 Natasha Najwa Nor Arfuzir,1 Vivian Wai-Ping Kong,3 Soon-Keng Cheong1,2 1Department of Research and Development, Cytopeutics Sdn Bhd, Cyberjaya, Selangor, Malaysia; 2M.
Chin SP +3 more
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Advancing CIK cell immunotherapy: highlights from the second international conference on DC-CIK and CAR-CIK approaches [PDF]
Cancer Immunology, ImmunotherapyOn April 7, 2025, the 2nd International CIK Cell Conference was held in Monza, Italy, marking the establishment of the International Society for CIK Cells (ISCC).
Amit Sharma +11 more
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Frontiers in ImmunologyIntroductionCAR-T cell therapy, though successful in hematologic malignancies, faces challenges in solid tumors due to limitations of autologous T cells.
Laura M. Moser +51 more
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Cell-based immunotherapy with cytokine-induced killer (CIK) cells: From preparation and testing to clinical application [PDF]
Human Vaccines & Immunotherapeutics, 2017 Cell-based immunotherapy holds promise in the quest for the treatment of cancer, having potential synergy with surgery, chemotherapy and radiotherapy.
Yiming Meng +10 more
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Innovative Clinical Perspectives for CIK Cells in Cancer Patients. [PDF]
Int J Mol Sci, 2018 Introna M, Correnti F.
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PLoS ONE, 2023 Background Cytokine-induced killer (CIK) cells are heterogeneous lymphocytes from human peripheral blood mononucleated cells (PBMCs) co-cultured with several cytokines.
Chan-Keng Yang +6 more
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