Results 151 to 160 of about 2,846 (197)

Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice. [PDF]

Sci Transl Med
Su L, Sun Q, Li Y, Alvarez JF, Tao B, Zhang G, Gu Y, Hanudel MR, Espinoza A, Zhang L, Pan C, Hilser JR, Hartiala JA, Li S, Pellegrini M, Allayee H, Lusis AJ, Deb A.   +17 more
europepmc   +1 more source

Cartilage Oligomeric Matrix Protein Promotes Radiation Resistance in Non-Small Cell Lung Cancer In Vitro. [PDF]

Int J Mol Sci
Reno KE, Costa-Terryll A, Park SH, Hughes RT, Farris MK, Xing F, Willey JS.   +6 more
europepmc   +1 more source

SMOC2 promotes partial epithelial-mesenchymal transition and maladaptive repair in renal tubular epithelial cells. [PDF]

JCI Insight
Cenatus S, Gao P, Henley N, Lamarche C, Liu XS, Mallette FA, Barrera-Chimal J, Gerarduzzi C.   +7 more
europepmc   +1 more source

A phase I study of cilengitide and paclitaxel in patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology, 2017
Cilengitide is a potent and selective inhibitor of the integrins αvβ3 and αvβ5. The primary objective of this phase I clinical trial was to establish the maximum tolerated dose and determine safety/tolerability of cilengitide in combination with paclitaxel in patients with advanced solid tumors.
Tufia C Haddad, Matthew P Goetz, Ruth Lupu   +2 more
exaly   +4 more sources

The αVβ3/αVβ5 integrin inhibitor cilengitide augments tumor response to melphalan isolated limb perfusion in a sarcoma model† ‡ [PDF]

International Journal of Cancer, 2013
Isolated limb perfusion (ILP) with melphalan and tumor necrosis factor (TNF)-α is used to treat bulky, locally advanced melanoma and sarcoma. However, TNF toxicity suggests a need for better-tolerated drugs.
Curzio Rüegg, Hagen Timo, Simon L Goodman   +2 more
exaly   +4 more sources

Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro. [PDF]

Neuro-Oncology, 2009
Cilengitide is a cyclic peptide antagonist of integrins alphavbeta3 and alphavbeta5 that is currently being evaluated as a novel therapeutic agent for recurrent and newly diagnosed glioblastoma.
Gabriele Maurer, Michael Weller, Ghazaleh Tabatabai   +2 more
exaly   +2 more sources

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The Integrin Inhibitor Cilengitide and Bleomycin-Induced Pulmonary Fibrosis

Lung, 2020
Fibroproliferation and excess deposition of extracellular matrix (ECM) are the pathologic hallmarks of idiopathic pulmonary fibrosis (IPF), a chronic progressive disorder with high mortality and suboptimal treatment options. Although the etiologic mechanisms responsible for the development and progression of IPF remain unclear, cell-ECM interactions ...
Jeffrey D. Ritzenthaler, Michael Zhang, Edilson Torres-Gonzalez, Jesse Roman   +3 more
openaire   +2 more sources

The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus [PDF]

Cancer Gene Therapy, 2013
Oncolytic viral (OV) therapy has been considered as a promising treatment modality for brain tumors. Vasculostatin, the fragment of brain-specific angiogenesis inhibitor-1, shows anti-angiogenic activity against malignant gliomas.
Balveen Kaur, Kazuhiko Kurozumi, J Ishida   +2 more
exaly   +2 more sources

Combination therapy of cilengitide with belotecan against experimental glioblastoma [PDF]

International Journal of Cancer, 2013
The prognosis of patients diagnosed with glioblastoma remains dismal in spite of the current concomitant chemoradiotherapy with temozolomide. In particular, the resistance to temozolomide appears to be the greatest obstacle to the treatment of glioblastoma.
Jung Ho Han, Chang Wan Oh, Chae-Yong Kim
exaly   +3 more sources

Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency† [PDF]

International Journal of Cancer, 2009
AbstractWe investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific inhibitor of αv series integrins, and acts as an antiangiogenic. U251 human glioma cells express αvβ3 and αvβ5 integrins.
Tom Mikkelsen, Stephen Brown, Michael E Berens   +2 more
exaly   +3 more sources