Results 1 to 10 of about 22,546 (116)

Targeting integrin αVβ3–Ptgs2–mTOR signaling rescues bone formation in osteoporosis: from molecular mechanism toward therapy [PDF]

Cellular & Molecular Biology Letters
Background Integrin αVβ3, a key ECM receptor, is essential for bone metabolism, yet its role in postmenopausal osteoporosis (PMOP) remains unclear. This study investigates the molecular mechanisms by which integrin αVβ3 regulates osteoblast function and ...
Changshun Chen, Jinyi Gu, Chenhui Yang, Fei Yang, Zirui Liu, Lei Wen, Rongjing Chen, Bin Geng, Yayi Xia   +8 more
doaj   +2 more sources

Involvement of integrin αvβ3 in thyroid hormone-induced dendritogenesis [PDF]

Frontiers in Endocrinology, 2022
Activation and/or modulation of the membrane-associated receptors plays a critical role in brain development. Thyroid hormone (TH) acts on both nuclear receptors (thyroid hormone receptor, TR) and membrane-associated receptors, particularly integrin αvβ3
Winda Ariyani, Winda Ariyani, Wataru Miyazaki, Wataru Miyazaki, Izuki Amano, Noriyuki Koibuchi   +5 more
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Interaction of integrin αvβ3 and fibronectin under fluid shear forces: implications for tumor cell adhesion and migration [PDF]

Frontiers in Cell and Developmental Biology
The interaction between integrin αvβ3 and fibronectin enables tumor cell adherence to endothelial layers under diverse hydrodynamic blood flow conditions, particularly in low shear stress regions.
Paimin Zhuo, Quhuan Li, Bishan Yang, Bishan Yang, Na Li, Zhiqing Luo, Fengxia Zhang   +6 more
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Exploiting Integrin-αVβ3 to Enhance Radiotherapy Efficacy in Medulloblastoma via Ferroptosis [PDF]

Current Oncology
Medulloblastoma, a malignant pediatric brain tumor, has a poor prognosis upon relapse, highlighting a critical clinical need. Our previous research linked medulloblastoma cell radioresistance to integrin-αvβ3 expression.
Célia Gotorbe, Fabien Segui, William Echavidre, Jérôme Durivault, Thays Blanchard, Valérie Vial, Marina Pagnuzzi-Boncompagni, Rémy Villeneuve, Régis Amblard, Nicolas Garnier, Cécile Ortholan, Benjamin Serrano, Vincent Picco, Jacques Pouysségur, Milica Vucetic, Christopher Montemagno   +15 more
doaj   +2 more sources

Integrin αVβ3 antagonist-c(RGDyk) peptide attenuates the progression of ossification of the posterior longitudinal ligament by inhibiting osteogenesis and angiogenesis [PDF]

Molecular Medicine
Background Ossification of the posterior longitudinal ligament (OPLL), an emerging heterotopic ossification disease, causes spinal cord compression, resulting in motor and sensory dysfunction. The etiology of OPLL remains unclear but may involve integrin
Xiangwu Geng, Yifan Tang, Changjiang Gu, Junkai Zeng, Yin Zhao, Quanwei Zhou, Lianshun Jia, Shengyuan Zhou, Xiongsheng Chen   +8 more
doaj   +2 more sources

Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress [PDF]

Cell Communication and Signaling, 2023
Background Integrins are closely related to mechanical conduction and play a crucial role in the osteogenesis of human mesenchymal stem cells. Here we wondered whether tensile stress could influence cell differentiation through integrin αVβ3.
Yan Peng, Rongmei Qu, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Wenqing Liu, Jinhui Zhu, Junxin Chen, Xiaoqing Li, Jingxing Dai, Jun Ouyang   +12 more
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FGF9, a Potent Mitogen, Is a New Ligand for Integrin αvβ3, and the FGF9 Mutant Defective in Integrin Binding Acts as an Antagonist [PDF]

Cells
FGF9 is a potent mitogen and survival factor, but FGF9 protein levels are generally low and restricted to a few adult organs. Aberrant expression of FGF9 usually results in cancer.
Chih-Chieh Chang, Yoko K. Takada, Chao-Wen Cheng, Yukina Maekawa, Seiji Mori, Yoshikazu Takada   +5 more
doaj   +2 more sources

Integrin αvβ3-dependent pathogenic effect and therapeutic effects of DL-N2 combined with EGFR inhibitors in pancreatic adenocarcinoma [PDF]

Journal of Translational Medicine
Background Pancreatic adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by aggressive progression, pronounced stromal desmoplasia, and a limited response to targeted therapies.
Zi-Lin Li, Sachin Kumar, San-Nan Yang, Tung-Cheng Chang, Lin-Yi Huang, Ching-Chung Ko, Yung-Ning Yang, Chih-Jung Yao, Dana R. Crawford, Fabio Gionfra, Dahlak Daniel Solomon, Yung-Kuo Lee, Do Thi Minh Xuan, Hui-Ru Lin, Chih-Yang Wang, Amruta Aher, Nandana Bayu Abhista, Ya-Jung Shih, Sheng-Yang Lee, Haw-Ming Huang, Hung-Yun Lin, Kuan Wang, Jaqueline Whang-Peng   +22 more
doaj   +2 more sources

Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells

Cells, 2021
Studies from our laboratory have suggested that activation of αvβ3 integrin-mediated signaling could contribute to the fibrotic-like changes observed in primary open angle glaucoma (POAG) and glucocorticoid-induced glaucoma.
Mark S. Filla, Kristy K. Meyer, Jennifer A. Faralli, Donna M. Peters   +3 more
doaj   +1 more source

Nano-Strategies Targeting the Integrin αvβ3 Network for Cancer Therapy

Cells, 2021
Integrin αvβ3, a cell surface receptor, participates in signaling transduction pathways in cancer cell proliferation and metastasis. Several ligands bind to integrin αvβ3 to regulate proliferation and metastasis in cancer cells.
Tsai-Mu Cheng, Wong-Jin Chang, Hsiu-Yi Chu, Roberto De Luca, Jens Z. Pedersen, Sandra Incerpi, Zi-Lin Li, Ya-Jung Shih, Hung-Yun Lin, Kuan Wang, Jacqueline Whang-Peng   +10 more
doaj   +1 more source