Results 41 to 50 of about 81,327 (201)

Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction

Frontiers in Molecular Biosciences, 2020
Inflammation contributes to the genesis and progression of chronic diseases, such as cancer and neurodegeneration. Upregulation of integrins in astrocytes during inflammation induces neurite retraction by binding to the neuronal protein Thy-1, also known
Francesca Burgos-Bravo, Francesca Burgos-Bravo, Francesca Burgos-Bravo, Samuel Martínez-Meza, Samuel Martínez-Meza, Andrew F. G. Quest, Andrew F. G. Quest, Christian A. M. Wilson, Lisette Leyton, Lisette Leyton   +9 more
doaj   +1 more source

Modulation of integrin activity for diagnostic and therapeutic applications [PDF]

, 2010
SUMMARY Over the past decade, the scientific research spent many efforts to develop therapeutic and diagnostic systems able to contact selectively the target cells and to minimize their diffusion in healthy organs.
De Simone, Mariarosaria
core   +1 more source

Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

BMC Biology, 2018
Background Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2 ...
Tomer Shlamkovich, Lidan Aharon, Dana Koslawsky, Yulia Einav, Niv Papo   +4 more
doaj   +1 more source

Integrin αvβ3 mediated adhesion to BM-ECM.

, 2012
Expression of αvβ3 integrin on LNCaP cells mediates adhesion to bone marrow-derived extracellular matrix (BM-ECM). (A) Cell surface expression of αvβ3 integrin as measured by flow cytometry. (B) Anti-αvβ3 integrin antibody reduced cell adhesion to BM-ECM.
Carsten Werner (145899), Marina Prewitz (145892), Reynald M. Lescarbeau (145881), F. Philipp Seib (145886), David L. Kaplan (131325)   +4 more
core   +1 more source

Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. [PDF]

PLoS ONE, 2015
Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However,
Seiji Mori, Moe Kodaira, Ayano Ito, Mika Okazaki, Naomasa Kawaguchi, Yoshinosuke Hamada, Yoshikazu Takada, Nariaki Matsuura   +7 more
doaj   +1 more source

Interaction of integrin αvβ3 and fibronectin under fluid shear forces: implications for tumor cell adhesion and migration

Frontiers in Cell and Developmental Biology
The interaction between integrin αvβ3 and fibronectin enables tumor cell adherence to endothelial layers under diverse hydrodynamic blood flow conditions, particularly in low shear stress regions.
Paimin Zhuo, Quhuan Li, Bishan Yang, Bishan Yang, Na Li, Zhiqing Luo, Fengxia Zhang   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

EJNMMI Research, 2019
Background Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ life quality.
Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier, Melanie A. Kimm   +9 more
doaj   +1 more source