Results 31 to 40 of about 81,327 (201)

3,5,3'-Triiodo-L-Thyronine Regulates Actin Cytoskeleton Dynamic in The Differentiated PC-12 Cells during Hypoxia through An αvβ3 Integrin [PDF]

Cell Journal, 2023
Objective: Thyroid hormones are involved in the pathogenesis of various neurological disorders. Ischemia/hypoxiathat induces rigidity of the actin filaments, which initiates neurodegeneration and reduces synaptic plasticity.
Tamar Barbakadze, Elisabed Kvergelidze, Judit Bátor, József Szeberényi, David Mikeladze   +4 more
doaj   +1 more source

Regulation of the integrin αVβ3- actin filaments axis in early osteogenesis of human fibroblasts under cyclic tensile stress

Stem Cell Research & Therapy, 2021
Background Integrins play a prominent role in osteogenic differentiation by transmitting both mechanical and chemical signals. Integrin expression is closely associated with tensile stress, which has a positive effect on osteogenic differentiation.
Yan Peng, Rongmei Qu, Yanting Feng, Xiaolan Huang, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Jingxing Dai, Jun Ouyang   +10 more
doaj   +1 more source

Role of Integrin αvβ3 in Doxycycline-Induced Anti-Proliferation in Breast Cancer Cells

Frontiers in Cell and Developmental Biology, 2022
Doxycycline, an antibiotic, displays the inhibition of different signal transduction pathways, such as anti-inflammation and anti-proliferation, in different types of cancers.
Yi-Fong Chen, Yi-Fong Chen, Yung-Ning Yang, Yung-Ning Yang, Hung-Ru Chu, Hung-Ru Chu, Tung-Yung Huang, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Han-Yu Chen, Zi-Lin Li, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis, Paul J. Davis   +23 more
doaj   +1 more source

Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation [PDF]

, 2011
Physiological as well as pathological blood vessel formation are fundamentally dependent on cell-matrix interaction. Integrins, a family of major cell adhesion receptors, play a pivotal role in development, maintenance, and remodeling of the vasculature.
Stephan Niland, Eble, Johannes A., Niland, Stephan, Johannes A. Eble   +3 more
core   +1 more source

Antagonizing αvβ3 Integrin Improves Ischemia-Mediated Vascular Normalization and Blood Perfusion by Altering Macrophages

Frontiers in Pharmacology, 2021
Background: αVβ3 integrin has been implicated in the physiological processes and pathophysiology of important angiogenesis-related disorders; however, the preclinical and clinical data on integrin αVβ3 antagonists have not demonstrated improved outcomes.
Yongjie Li, Yongjie Li, Qian Gao, Qian Gao, Xin Shu, Xin Shu, Lamei Xiao, Lamei Xiao, Yan Yang, Yan Yang, Ningbo Pang, Ningbo Pang, Yulin Luo, Yulin Luo, Jing He, Jing He, Liping Zhang, Liping Zhang, Jianbo Wu, Jianbo Wu   +19 more
doaj   +1 more source

An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA [PDF]

, 2012
Conradi J, Tegtmeyer N, Wozna M, et al. An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA. Frontiers in Cellular and Infection Microbiology.
Backert, Steffen, Tegtmeyer, Nicole, Timothy L Cover, Steffen Backert, Gagell, Corinna, Marta eWoźna, Marco eWissbrock, Cover, Timothy L., Sewald, Norbert ; https://orcid.org/, Michalek, Carmela, Frank, Ronald, Ronald eFrank, Norbert eSewald, Jens eConradi, Nicole Tegtmeyer, Carmela Michalek, Corinna eGagell, Jens Conradi, Steffen eBackert, Norbert Sewald, Carmela eMichalek, Marco Wissbrock, Wißbrock, Marco, Timothy L. Cover, Wozna, Marta, Marta Woźna, Corinna Gagell, Ronald Frank, Conradi, Jens, Nicole eTegtmeyer   +29 more
core   +1 more source

Induction of ligand promiscuity of αVβ3 integrin by mechanical force [PDF]

, 2020
αVβ3 integrin can bind to multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn), which are often presented to cells in culture as homogenous substrates.
Hytönen, Vesa P, Heiser, Lia, Krübel, Sarah, Franz, Clemens M., Wehrle-Haller, Bernhard, Bastmeyer, Martin, Franz, Clemens M, Mykuliak, Vasyl V., Ripamonti, Marta, Mykuliak, Vasyl V, Bachmann, Michael, Hytönen, Vesa P., Weißenbruch, Kai, Schäfer, Markus   +13 more
core   +1 more source

Expression of integrin αvβ3 in pig, dog and cattle [PDF]

, 2011
The αvβ3 integrin, also known as vitronectin receptor, is an adhesive glycoprotein that promotes angiogenesis i n the embryo and tumors such as melanoma. Integrin αvβ3 is one of the receptors for adenovirus and hantavirus.
Kaur, A., Singh, B., Rawlings, N.
core   +2 more sources

The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.

PLoS ONE, 2014
The chemokine domain of fractalkine (FKN-CD) binds to the classical RGD-binding site of αvβ3 and that the resulting ternary complex formation (integrin-FKN-CX3CR1) is critical for CX3CR1 signaling and FKN-induced integrin activation.
Masaaki Fujita, Yoko K Takada, Yoshikazu Takada   +2 more
doaj   +1 more source

Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure

Reproductive Biology and Endocrinology, 2021
Objective The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus.
Li Zhou, Chenggang Li, Xiangshu Liu, Tao Zhang   +3 more
doaj   +1 more source