Results 21 to 30 of about 81,327 (201)

FGF9, a Potent Mitogen, Is a New Ligand for Integrin αvβ3, and the FGF9 Mutant Defective in Integrin Binding Acts as an Antagonist [PDF]

Cells
FGF9 is a potent mitogen and survival factor, but FGF9 protein levels are generally low and restricted to a few adult organs. Aberrant expression of FGF9 usually results in cancer.
Chih-Chieh Chang, Yoko K. Takada, Chao-Wen Cheng, Yukina Maekawa, Seiji Mori, Yoshikazu Takada   +5 more
doaj   +2 more sources

The Role of αvβ3 Integrin in Cancer Therapy Resistance

Biomedicines
A relevant challenge for the treatment of patients with neoplasia is the development of resistance to chemo-, immune-, and radiotherapies. Although the causes of therapy resistance are poorly understood, evidence suggests it relies on compensatory ...
Bianca Cruz Pachane, Heloisa S. Selistre-de-Araujo   +1 more
doaj   +2 more sources

Force regulated conformational change of integrin αVβ3

, 2016
Integrins mediate cell adhesion to extracellular matrix and transduce signals bidirectionally across the membrane. Integrin αVβ3 has been shown to play an essential role in tumor metastasis, angiogenesis, hemostasis and phagocytosis.
Schwartz, Martin
core   +11 more sources

αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells

Viruses, 2021
The Flavivirus genus includes a number of important viruses that are pathogenic to humans and animals and are responsible for outbreaks across the globe.
Vinicius Pinho dos Reis, Markus Keller, Katja Schmidt, Rainer Günter Ulrich, Martin Hermann Groschup   +4 more
doaj   +1 more source

Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells

Cell Adhesion & Migration, 2023
The role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous ...
Lan Huang, Yao Zhu, Qinglin Kong, Xianmin Guan, Xiaoying Lei, Luying Zhang, Hui Yang, Xinyuan Yao, Shaoyan Liang, Xizhou An, Jie Yu   +10 more
doaj   +1 more source

The challenges and opportunities of αvβ3-based therapeutics in cancer: From bench to clinical trials

Pharmacological Research, 2023
Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals between cells and their environment.
Yanlun Gu, Bingqi Dong, Xu He, Zhiwei Qiu, Juqi Zhang, Mo Zhang, Haitao Liu, Xiaocong Pang, Yimin Cui   +8 more
doaj   +1 more source

Matrix metalloproteinase-2 promotes αvβ3 integrin-mediated adhesion and migration of human melanoma cells by cleaving fibronectin. [PDF]

PLoS ONE, 2012
BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is a key regulator in the migration of tumor cells. αvβ3 integrin has been reported to play a critical role in cell adhesion and regulate the migration of tumor cells by promoting MMP-2 activation.
Yang Jiao, Xue Feng, Yinpeng Zhan, Ruifei Wang, Sheng Zheng, Wenguang Liu, Xianlu Zeng   +6 more
doaj   +1 more source

Inhibition by Thyroid Hormones of Cell Migration Activated by IGF-1 and MCP-1 in THP-1 Monocytes: Focus on Signal Transduction Events Proximal to Integrin αvβ3

Frontiers in Cell and Developmental Biology, 2021
Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T4, but also T3, act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for ...
Elena Candelotti, Roberto De Luca, Roberto Megna, Mariangela Maiolo, Paolo De Vito, Fabio Gionfra, Zulema Antonia Percario, Monica Borgatti, Roberto Gambari, Paul J. Davis, Paul J. Davis, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Fabio Polticelli, Tiziana Persichini, Marco Colasanti, Elisabetta Affabris, Jens Z. Pedersen, Sandra Incerpi   +21 more
doaj   +1 more source

The epithelial αvβ3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components. [PDF]

PLoS Pathogens, 2014
TLR2 is a cell surface receptor which elicits an immediate response to a wide repertoire of bacteria and viruses. Its response is usually thought to be proinflammatory rather than an antiviral.
Tatiana Gianni, Gabriella Campadelli-Fiume   +1 more
doaj   +1 more source

Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression.

PLoS ONE, 2021
Neuroendocrine prostate cancer (NEPrCa) arises de novo or after accumulation of genomic alterations in pre-existing adenocarcinoma tumors in response to androgen deprivation therapies.
Fabio Quaglia, Shiv Ram Krishn, Yanqing Wang, David W Goodrich, Peter McCue, Andrew V Kossenkov, Amy C Mandigo, Karen E Knudsen, Paul H Weinreb, Eva Corey, William K Kelly, Lucia R Languino   +11 more
doaj   +1 more source