Results 21 to 30 of about 22,584 (153)

Regulation of the integrin αVβ3- actin filaments axis in early osteogenesis of human fibroblasts under cyclic tensile stress

Stem Cell Research & Therapy, 2021
Background Integrins play a prominent role in osteogenic differentiation by transmitting both mechanical and chemical signals. Integrin expression is closely associated with tensile stress, which has a positive effect on osteogenic differentiation.
Yan Peng, Rongmei Qu, Yanting Feng, Xiaolan Huang, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Jingxing Dai, Jun Ouyang   +10 more
doaj   +1 more source

Role of Integrin αvβ3 in Doxycycline-Induced Anti-Proliferation in Breast Cancer Cells

Frontiers in Cell and Developmental Biology, 2022
Doxycycline, an antibiotic, displays the inhibition of different signal transduction pathways, such as anti-inflammation and anti-proliferation, in different types of cancers.
Yi-Fong Chen, Yi-Fong Chen, Yung-Ning Yang, Yung-Ning Yang, Hung-Ru Chu, Hung-Ru Chu, Tung-Yung Huang, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Han-Yu Chen, Zi-Lin Li, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis, Paul J. Davis   +23 more
doaj   +1 more source

Antagonizing αvβ3 Integrin Improves Ischemia-Mediated Vascular Normalization and Blood Perfusion by Altering Macrophages

Frontiers in Pharmacology, 2021
Background: αVβ3 integrin has been implicated in the physiological processes and pathophysiology of important angiogenesis-related disorders; however, the preclinical and clinical data on integrin αVβ3 antagonists have not demonstrated improved outcomes.
Yongjie Li, Yongjie Li, Qian Gao, Qian Gao, Xin Shu, Xin Shu, Lamei Xiao, Lamei Xiao, Yan Yang, Yan Yang, Ningbo Pang, Ningbo Pang, Yulin Luo, Yulin Luo, Jing He, Jing He, Liping Zhang, Liping Zhang, Jianbo Wu, Jianbo Wu   +19 more
doaj   +1 more source

Non-invasively differentiating extent of liver fibrosis by visualizing hepatic integrin αvβ3 expression with an MRI modality in mice

Biomaterials, 2016
To explore the potential of a dendrimer nanoprobe labeled with cyclic arginine-glycine-aspartic acid pentapeptide (cRGDyK) as a magnetic resonance imaging (MRI) tracer to non-invasively differentiate the extent of liver fibrosis.Synthetic dendrimer nanoprobes were labeled with cRGDyK (Den-RGD) to form a formulation of hepatic stellate cell (HSC ...
Li, Feng, Yan, Huihui, Wang, Jiyao, Li, Cong, Wu, Jian, Wu, Shengdi, Rao, Shengxiang, Gao, Xihui, Jin, Qu   +8 more
openaire   +4 more sources

Multimodality tumor imaging targeting integrin αvβ3

BioTechniques, 2005
The cell adhesion molecule integrin αvβ3 is an important player in the process of tumor angiogenesis and metastasis. Antibodies, peptides, peptidomimetics, and small molecule antagonists against integrin αvβ3 have been shown to induce endothelial ...
Weibo Cai, Sanjiv Sam Gambhir, Xiaoyuan Chen   +2 more
doaj   +1 more source

The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.

PLoS ONE, 2014
The chemokine domain of fractalkine (FKN-CD) binds to the classical RGD-binding site of αvβ3 and that the resulting ternary complex formation (integrin-FKN-CX3CR1) is critical for CX3CR1 signaling and FKN-induced integrin activation.
Masaaki Fujita, Yoko K Takada, Yoshikazu Takada   +2 more
doaj   +1 more source

Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure

Reproductive Biology and Endocrinology, 2021
Objective The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus.
Li Zhou, Chenggang Li, Xiangshu Liu, Tao Zhang   +3 more
doaj   +1 more source

Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction

Frontiers in Molecular Biosciences, 2020
Inflammation contributes to the genesis and progression of chronic diseases, such as cancer and neurodegeneration. Upregulation of integrins in astrocytes during inflammation induces neurite retraction by binding to the neuronal protein Thy-1, also known
Francesca Burgos-Bravo, Francesca Burgos-Bravo, Francesca Burgos-Bravo, Samuel Martínez-Meza, Samuel Martínez-Meza, Andrew F. G. Quest, Andrew F. G. Quest, Christian A. M. Wilson, Lisette Leyton, Lisette Leyton   +9 more
doaj   +1 more source

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Angewandte Chemie, EarlyView.
Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher   +7 more
wiley   +2 more sources

Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

BMC Biology, 2018
Background Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2 ...
Tomer Shlamkovich, Lidan Aharon, Dana Koslawsky, Yulia Einav, Niv Papo   +4 more
doaj   +1 more source