Results 11 to 20 of about 81,327 (201)

Nano-Strategies Targeting the Integrin αvβ3 Network for Cancer Therapy

Cells, 2021
Integrin αvβ3, a cell surface receptor, participates in signaling transduction pathways in cancer cell proliferation and metastasis. Several ligands bind to integrin αvβ3 to regulate proliferation and metastasis in cancer cells.
Tsai-Mu Cheng, Wong-Jin Chang, Hsiu-Yi Chu, Roberto De Luca, Jens Z. Pedersen, Sandra Incerpi, Zi-Lin Li, Ya-Jung Shih, Hung-Yun Lin, Kuan Wang, Jacqueline Whang-Peng   +10 more
doaj   +2 more sources

Multimodality tumor imaging targeting integrin αvβ3

BioTechniques, 2005
The cell adhesion molecule integrin αvβ3 is an important player in the process of tumor angiogenesis and metastasis. Antibodies, peptides, peptidomimetics, and small molecule antagonists against integrin αvβ3 have been shown to induce endothelial ...
Weibo Cai, Sanjiv Sam Gambhir, Xiaoyuan Chen   +2 more
doaj   +2 more sources

c-Abl Kinase Is a Regulator of αvβ3 Integrin Mediated Melanoma A375 Cell Migration. [PDF]

PLoS ONE, 2013
Integrins are heterodimeric transmembrane receptors that physically link the extracellular matrix (ECM) to the intracellular actin cytoskeleton, and are also signaling molecules that transduce signals bi-directionally across the plasma membrane. Integrin
Chunmei Zhang, Chao Yang, Ruifei Wang, Yang Jiao, Khamal Kwesi Ampah, Xiaoguang Wang, Xianlu Zeng   +6 more
doaj   +2 more sources

Interaction between CD82 and integrin αVβ3 selectively regulates collective movement of tumor cells via endolysosomal trafficking [PDF]

Cellular and Molecular Life Sciences
Tetraspanin CD82/KAI1 inhibits cell movement and metastasis of malignant tumors, and reduced and lost expressions of CD82 predict worse outcomes of patients with malignant tumors.
Xue Jun Wang, Mekel M. Richardson, Yingjun Ding, Chao Jiang, Songlan Liu, Bin Zhou, Shuping Li, Junxiong Chen, Eric Rubinstein, Franklin A. Hays, Kamiya Mehla, Xin A. Zhang   +11 more
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Targeting integrin αVβ3–Ptgs2–mTOR signaling rescues bone formation in osteoporosis: from molecular mechanism toward therapy [PDF]

Cellular & Molecular Biology Letters
Background Integrin αVβ3, a key ECM receptor, is essential for bone metabolism, yet its role in postmenopausal osteoporosis (PMOP) remains unclear. This study investigates the molecular mechanisms by which integrin αVβ3 regulates osteoblast function and ...
Changshun Chen, Jinyi Gu, Chenhui Yang, Fei Yang, Zirui Liu, Lei Wen, Rongjing Chen, Bin Geng, Yayi Xia   +8 more
doaj   +2 more sources

Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells

Cells, 2021
Studies from our laboratory have suggested that activation of αvβ3 integrin-mediated signaling could contribute to the fibrotic-like changes observed in primary open angle glaucoma (POAG) and glucocorticoid-induced glaucoma.
Mark S. Filla, Kristy K. Meyer, Jennifer A. Faralli, Donna M. Peters   +3 more
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Involvement of integrin αvβ3 in thyroid hormone-induced dendritogenesis [PDF]

Frontiers in Endocrinology, 2022
Activation and/or modulation of the membrane-associated receptors plays a critical role in brain development. Thyroid hormone (TH) acts on both nuclear receptors (thyroid hormone receptor, TR) and membrane-associated receptors, particularly integrin αvβ3
Winda Ariyani, Winda Ariyani, Wataru Miyazaki, Wataru Miyazaki, Izuki Amano, Noriyuki Koibuchi   +5 more
doaj   +2 more sources

Exploiting Integrin-αVβ3 to Enhance Radiotherapy Efficacy in Medulloblastoma via Ferroptosis [PDF]

Current Oncology
Medulloblastoma, a malignant pediatric brain tumor, has a poor prognosis upon relapse, highlighting a critical clinical need. Our previous research linked medulloblastoma cell radioresistance to integrin-αvβ3 expression.
Célia Gotorbe, Fabien Segui, William Echavidre, Jérôme Durivault, Thays Blanchard, Valérie Vial, Marina Pagnuzzi-Boncompagni, Rémy Villeneuve, Régis Amblard, Nicolas Garnier, Cécile Ortholan, Benjamin Serrano, Vincent Picco, Jacques Pouysségur, Milica Vucetic, Christopher Montemagno   +15 more
doaj   +2 more sources

Integrin αVβ3 antagonist-c(RGDyk) peptide attenuates the progression of ossification of the posterior longitudinal ligament by inhibiting osteogenesis and angiogenesis [PDF]

Molecular Medicine
Background Ossification of the posterior longitudinal ligament (OPLL), an emerging heterotopic ossification disease, causes spinal cord compression, resulting in motor and sensory dysfunction. The etiology of OPLL remains unclear but may involve integrin
Xiangwu Geng, Yifan Tang, Changjiang Gu, Junkai Zeng, Yin Zhao, Quanwei Zhou, Lianshun Jia, Shengyuan Zhou, Xiongsheng Chen   +8 more
doaj   +2 more sources

Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress [PDF]

Cell Communication and Signaling, 2023
Background Integrins are closely related to mechanical conduction and play a crucial role in the osteogenesis of human mesenchymal stem cells. Here we wondered whether tensile stress could influence cell differentiation through integrin αVβ3.
Yan Peng, Rongmei Qu, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Wenqing Liu, Jinhui Zhu, Junxin Chen, Xiaoqing Li, Jingxing Dai, Jun Ouyang   +12 more
doaj   +2 more sources