Results 1 to 10 of about 2,291 (112)

Overcoming Regorafenib Resistance in Colorectal Cancer: Synergistic Efficacy of Cilengitide in HT29 and WiDr Cells [PDF]

Medeniyet Medical Journal
Objective: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Regorafenib, a multikinase inhibitor, is approved for the treatment of metastatic CRC; however, the emergence of drug resistance significantly limits ...
Asiye Busra BOZ, Zuhal SEMIZ, Fikret YANAR   +2 more
doaj   +2 more sources

Cilengitide inhibits osteoclast adhesion through blocking the αvβ3-mediated FAK/Src signaling pathway

Heliyon, 2023
The remodeling of actin cytoskeleton of osteoclasts on the bone matrix is essential for osteoclastic resorption activity. A specific regulator of the osteoclast cytoskeleton, integrin αvβ3, is known to provide a key role in the degradation of mineralized
Zhonghua Chen, Zheng-Dong Yuan
exaly   +3 more sources

Integrin-Associated Signalling Regulates Jagged1-Induced Osteogenic Differentiation of Human Dental Pulp Stem Cells [PDF]

International Dental Journal
Aim: To investigate the role of integrin-associated adhesion signalling in Jagged1-driven osteogenic differentiation and to determine the specific contribution of integrin β3 (ITGβ3).
Chatvadee Kornsuthisopon, Ajjima Chansaenroj, Suphalak Phothichailert, Betul Gedik, Chengfei Zhang, Nunthawan Nowwarote, Quan Yuan, Lucy Di Silvio, Thanaphum Osathanon   +8 more
doaj   +2 more sources

Interaction between CD82 and integrin αVβ3 selectively regulates collective movement of tumor cells via endolysosomal trafficking [PDF]

Cellular and Molecular Life Sciences
Tetraspanin CD82/KAI1 inhibits cell movement and metastasis of malignant tumors, and reduced and lost expressions of CD82 predict worse outcomes of patients with malignant tumors.
Xue Jun Wang, Mekel M. Richardson, Yingjun Ding, Chao Jiang, Songlan Liu, Bin Zhou, Shuping Li, Junxiong Chen, Eric Rubinstein, Franklin A. Hays, Kamiya Mehla, Xin A. Zhang   +11 more
doaj   +2 more sources

Irisin maintains ER homeostasis and activates AMPK via integrin αVβ5 to attenuate CSE + LPS-induced emphysema and inflammation [PDF]

Respiratory Research
Background AECOPD adversely affects patient survival rates and overall quality of life. Irisin is being increasingly recognized for its therapeutic potential in attenuating pulmonary injury, but its underlying mechanism remains unclear.
Zina Bai, Tongxinwei Sun, Zelin Chen, Siqin Han, Jingwen Li, Xiaopeng Zhang, Cuiqing Ma, Yahong Chen, Ping Jiang, Xixin Yan, Aihong Meng   +10 more
doaj   +2 more sources

Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell [PDF]

Cell Communication and Signaling
Abnormal expression of POSTN is closely related to the development of cancer, especially in colorectal cancer (CRC). However, the effects and mechanisms of POSTN on CRC progression under high-fat diet (HFD) have not been thoroughly studied. The effect of
Biao Li, Shasha Hou, Tian Tian, Shuai Yuan, Anrui Li, Yao Feng, Zhuoxi Liu, Jing Mi, Zhengyi Cheng, Shengnan Lv, Jiajun Yang, Yiming Lu, Xinlai Qi, Shiqi Song, Zijuan Zha, Qi Yuan   +15 more
doaj   +2 more sources

Integrin-Mediated TIMP1 Signaling Reprograms Liver Macrophages and Accelerates Colorectal Cancer Metastasis [PDF]

Cells
Background: Colorectal cancer (CRC) frequently metastasizes to the liver (CRLM), where M2-polarized macrophages shape an immunosuppressive pre-metastatic niche. The molecular cues driving this polarization remain unclear.
Jialiang Liu, Liming Zhao, Lin Wang, Guoli Sheng, Pu Cheng, Mingyu Han, Guoxin Li, Zhaoxu Zheng   +7 more
doaj   +2 more sources

DANEELpath open source digital analysis tools for histopathological research in neuroblastoma models [PDF]

Scientific Reports
Despite the considerable expansion of bioimage analysis as a subfield of biomedical sciences, there is an ongoing need for comprehensive image analysis pipelines to address specific biological inquiries.
Isaac Vieco-Martí, Amparo López-Carrasco, Samuel Navarro, Sofia Granados-Aparici, Rosa Noguera   +4 more
doaj   +2 more sources

Antagonizing αvβ3 Integrin Improves Ischemia-Mediated Vascular Normalization and Blood Perfusion by Altering Macrophages

Frontiers in Pharmacology, 2021
Background: αVβ3 integrin has been implicated in the physiological processes and pathophysiology of important angiogenesis-related disorders; however, the preclinical and clinical data on integrin αVβ3 antagonists have not demonstrated improved outcomes.
Yongjie Li, Yongjie Li, Qian Gao, Qian Gao, Xin Shu, Xin Shu, Lamei Xiao, Lamei Xiao, Yan Yang, Yan Yang, Ningbo Pang, Ningbo Pang, Yulin Luo, Yulin Luo, Jing He, Jing He, Liping Zhang, Liping Zhang, Jianbo Wu, Jianbo Wu   +19 more
doaj   +1 more source

Cilengitide-induced temporal variations in transvascular transfer parameters of tumor vasculature in a rat glioma model: identifying potential MRI biomarkers of acute effects. [PDF]

PLoS ONE, 2013
Increased efficacy of radiotherapy (RT) 4-8 h after Cilengitide treatment has been reported. We hypothesized that the effects of Cilengitide on tumor transvascular transfer parameters might underlie, and thus predict, this potentiation. Athymic rats with
Tavarekere N Nagaraja, Madhava P Aryal, Stephen L Brown, Hassan Bagher-Ebadian, Tom Mikkelsen, James J Yang, Swayamprava Panda, Kelly A Keenan, Glauber Cabral, James R Ewing   +9 more
doaj   +1 more source