Results 11 to 20 of about 2,846 (197)

Cilengitide sensitivity is predicted by overall integrin expression in breast cancer

Breast Cancer Research
Background Treatment options for triple-negative breast cancer (TNBC) are limited and patients face a poor prognosis. Here, we sought to identify drugs that target TNBC vulnerabilities and understand the biology underlying these responses.
Nomeda Girnius, Aylin Z. Henstridge, Benjamin Marks, Jeffrey K. Yu, G. Kenneth Gray, Chris Sander, Ioannis K. Zervantonakis, Augustin Luna   +7 more
doaj   +4 more sources

Gene expression profiling of the anti-glioma effect of Cilengitide [PDF]

SpringerPlus, 2013
Abstract Cilengitide (EMD121974), an inhibitor of the adhesive function of integrins, demonstrated preclinical efficacy against malignant glioma. It is speculated that cilengitide can inhibit tumor growth, invasion, and angiogenesis. However, the effects of cilengitide on these processes have not been sufficiently examined.
Onishi, Manabu, Kurozumi, Kazuhiko, Ichikawa, Tomotsugu, Michiue, Hiroyuki, Fujii, Kentaro, Ishida, Joji, Shimazu, Yosuke, Chiocca, E Antonio, Kaur, Balveen, Date, Isao   +9 more
core   +6 more sources

Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma [PDF]

Journal of Clinical Oncology, 2010
Purpose Invasion and migration are key processes of glioblastoma and are tightly linked to tumor recurrence. Integrin inhibition using cilengitide has shown synergy with chemotherapy and radiotherapy in vitro and promising activity in recurrent glioblastoma.
Stupp, R, Hegi, M E, Neyns, B, Goldbrunner, R, Schlegel, U, Clement, P M, Grabenbauer, G G, Ochsenbein, A F, Simon, M, Dietrich, P Y, Pietsch, T, Hicking, C, Tonn, J C, Diserens, A C, Pica, A, Hermisson, M, Krueger, S, Picard, M, Weller, M   +18 more
openaire   +10 more sources

A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer [PDF]

BMC Cancer, 2006
Background Anti-angiogenic treatment is believed to have at least cystostatic effects in highly vascularized tumours like pancreatic cancer. In this study, the treatment effects of the angiogenesis inhibitor Cilengitide and gemcitabine were compared with
Katz Frieder, Balcke Peter, Hawkins Robert, Scheithauer Werner, Dobrowolski Frank, Piedbois Pascal, Herzog Peter, Neyns Bart, Stöger Herbert, Hossfeld Dieter K, Dittrich Christian, Niedergethmann Marco, Raedle Jochen, Oettle Helmut, Langrehr Jan M, Friess Helmut, Vermorken Jan, van Belle Simon, Davidson Neville, Esteve Albert, Castellano Daniel, Kleeff Jörg, Tempia-Caliera Adrien A, Kovar Andreas, Nippgen Johannes   +24 more
doaj   +3 more sources

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway [PDF]

Journal of Experimental & Clinical Cancer Research, 2008
Background The antiangiogenic agent cilengitide disrupts integrin binding to the extracellular matrix leading to apoptosis of activated endothelial cells. Integrins are also widely expressed in malignant glioma and integrin inhibitors may directly target
Nippgen Johannes, Bokemeyer Carsten, Fiedler Walter, Hauschild Jessica, Oliveira-Ferrer Leticia, Celik Ilhan, Schuch Gunter   +6 more
doaj   +2 more sources

Energetic description of cilengitide bound to integrin

New Journal of Chemistry, 2017
We employ quantum chemistry methods to investigate the binding energy features of the cyclic RGD pentapeptide cilengitide interacting with the integrin receptor α V β 3 .
José X. Lima Neto, Katyanna S. Bezerra, Dalila N. Manso, Kyvia B. Mota, Jonas I. N. Oliveira, Eudenilson L. Albuquerque, Ewerton W. S. Caetano, Valder N. Freire, Umberto L. Fulco   +8 more
openaire   +2 more sources

The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.

PLoS ONE, 2009
Cilengitide is a high-affinity cyclic pentapeptdic alphaV integrin antagonist previously reported to suppress angiogenesis by inducing anoikis of endothelial cells adhering through alphaVbeta3/alphaVbeta5 integrins.
Gian Carlo Alghisi, Lionel Ponsonnet, Curzio Rüegg   +2 more
doaj   +2 more sources

Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome [PDF]

Oncotarget, 2016
Integrins αvβ3 and αvβ5 regulate angiogenesis and invasiveness in cancer, potentially by modulating activation of the transforming growth factor (TGF)-β pathway. The randomized phase III CENTRIC and phase II CORE trials explored the integrin inhibitor cilengitide in patients with newly diagnosed glioblastoma with versus without O6-methylguanine DNA ...
Weller, Michael, Nabors, Louis Burt, Gorlia, Thierry, Leske, Henning, Rushing, Elisabeth J, Bady, Pierre, Hicking, Christine, Perry, James, Hong, Yong-Kil, Roth, Patrick, Wick, Wolfgang, Goodman, Simon L, Hegi, Monika E, Picard, Martin, Moch, Holger, Straub, Josef, Stupp, Roger   +16 more
openaire   +7 more sources

Very long-term survival of an older glioblastoma patient after treatment with cilengitide: a case report

CNS Oncology, 2023
Glioblastoma (GBM) is the most common malignant brain tumor. Less than 1% of patients survive longer than 10 years. A 77-year-old woman was diagnosed with MGMT-methylated GBM in 2009. The patient received cilengitide as part of the CENTRIC clinical trial
Huda Alalami, Serguei Bannykh, Xuemo Fan, Jethro Hu   +3 more
doaj   +2 more sources

Effect of the integrin inhibitor cilengitide on TGF-beta signaling.

Journal of Clinical Oncology, 2012
2055 Background: Glioblastoma is the most malignant form of intrinsic brain tumors. One of its characteristic features, angiogenesis, is mediated by the expression of integrins αvβ3 and αvβ5 on tumor-associated vasculature. Cilengitide is a synthetic peptide which inhibits ligand binding to the αvβ3 and αvβ5 integrins.
Weller, Michael, Silginer, Manuela, Goodman, Simon L., Hasenbach, Kathy, Thies, Svenja, Schraml, Peter, Tabatabai, Ghazaleh, Moch, Holger, Tritschler, Isabel, Roth, Patrick   +9 more
openaire   +3 more sources