Results 41 to 50 of about 2,846 (197)

Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies [PDF]

, 2011
Cilengitide, a cyclicized arginine-glycine-aspartic acid-containing pentapeptide, potently blocks ανβ3 and ανβ5 integrin activation. Integrins are upregulated in many malignancies and mediate a wide variety of tumor-stroma interactions.
Bart Neyns, Louis Burt Nabors, Reardon, D.A., Neyns, B., Neyns, B, Roger Stupp, Stupp, R., Tonn, J C, Joerg Christian Tonn, Nabors, L B, Tonn, J.C., Stupp, R, Michael Weller, David A Reardon, Weller, M, Weller, M., Reardon, D A, Nabors, L.B.   +17 more
core   +1 more source

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

Cell Reports, 2017
Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanisms regulating senescence are not well characterized.
Valentina Rapisarda, Michela Borghesan, Veronica Miguela, Vesela Encheva, Ambrosius P. Snijders, Amaia Lujambio, Ana O’Loghlen   +6 more
doaj   +1 more source

Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts. [PDF]

PLoS ONE, 2017
A hypoxic stress which causes apoptosis of cardiomyocytes is the main problem in the ischemic heart disease. Canstatin, a non-collagenous fragment of type IV collagen α2 chain, is an endogenous anti-angiogenic factor.
Hiroki Kanazawa, Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawaki   +3 more
doaj   +1 more source

The Evolving Role of the Oncologic Neurosurgeon: Looking Beyond Extent of Resection in the Modern Era

Frontiers in Oncology, 2018
Neurosurgeons have played an essential role in glioma management and research for over a century. While the past twenty years have played witness to many exciting developments in glioma biology, diagnosis, and classification, relatively few novel ...
Stephen G. Bowden, Seunggu Jude Han
doaj   +1 more source

Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice

Journal of Neuroinflammation, 2022
Background Neuroinflammation is a crucial factor in the development of secondary brain injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers strong neuroprotective effects in experimental ischemic stroke. However,
Yao Wang, Mi Tian, Jiaying Tan, Xu Pei, Chaocheng Lu, Yuewen Xin, Shuixiang Deng, Feng Zhao, Yanqin Gao, Ye Gong   +9 more
doaj   +1 more source

The Integrin Inhibitor Cilengitide Affects Meningioma Cell Motility and Invasion [PDF]

Clinical Cancer Research, 2013
Abstract Purpose: Meningiomas are frequent intracranial or spinal neoplasms, which recur frequently and can show aggressive clinical behaviour. We elucidated the impact of the integrin inhibitor cilengitide on migration, proliferation, and radiosensitization of meningioma cells.
Annette, Wilisch-Neumann, Nadine, Kliese, Doreen, Pachow, Thomas, Schneider, Jan-Peter, Warnke, Werner Ek, Braunsdorf, Frank-Dietmar, Böhmer, Peter, Hass, Diana, Pasemann, Cornelia, Helbing, Elmar, Kirches, Christian, Mawrin   +11 more
openaire   +2 more sources

Cilengitide augments the permeability of HUVEC monolayers.

, 2013
(a). HUVEC were grown on fibronectin- or collagen I-coated PET filter inserts for 20 hours to ensure confluence and treated with cilengitide (10 µM), CGP77675 (2.5 µM) or a combination thereof.
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source

Cilengitide: A Prototypic Integrin Inhibitor for the Treatment of Glioblastoma and Other Malignancies [PDF]

Genes & Cancer, 2011
Integrins are critical intermediaries in a wide spectrum of cancer cell activities and thus represent a highly attractive target in oncology therapy. Nonetheless, successful exploitation of anti-integrin therapeutics has proven challenging to date for cancer patients.
David A, Reardon, David, Cheresh
openaire   +2 more sources

A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation

Journal of Experimental & Clinical Cancer Research, 2021
Background Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma (HCC).
Gang Chen, Yi Wang, Xin Zhao, Xiao-zai Xie, Jun-gang Zhao, Tuo Deng, Zi-yan Chen, Han-bin Chen, Yi-fan Tong, Zhen Yang, Xi-wei Ding, Peng-yi Guo, Hai-tao Yu, Li-jun Wu, Si-na Zhang, Qian-dong Zhu, Jun-jian Li, Yun-feng Shan, Fu-xiang Yu, Zheng-ping Yu, Jing-lin Xia   +20 more
doaj   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source