Results 51 to 60 of about 2,846 (197)

Cilengitide activates αVβ3 on HUVEC.

, 2013
(a) HUVEC in suspension were exposed to 10 µM of cilengitide or EMD135981 for 10 minutes, stained by immunofluorescence for β3 LIBS and total αVβ3 expression (with LIBS-1 and LM609 mAbs, respectively) and analyzed by flow cytometry.
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial [PDF]

, 2014
Background Cilengitide is a selective alpha v beta 3 and alpha v beta 5 integrin inhibitor. Data from phase 2 trials suggest that it has antitumour activity as a single agent in recurrent glioblastoma and in combination with standard temozolomide ...
Schnell, Oliver, Taphoorn, Martin J B, Grujicic, Danica, McBain, Catherine, Markivskyy, Andriy, Weyerbrock, Astrid, Lhermitte, Benoit, Tarnawski, Rafał, van den Bent, Martin J, Wick, Wolfgang, Brandes, Alba A, Erridge, Sara C, Nam, Do-Hyun, Gupta, Tejpal, Wiegel, Thomas, Pietsch, Torsten, Rao, Nalini, Perry, James, Thurzo, László, Adamska, Krystyna, Shen, Chiung-Chyi, Kim, Chae-Yong, Hegi, Monika E, Aldape, Kenneth D, Weller, Michael, Stupp, Roger, Kortmann, Rolf-Dieter, Hong, Yong-Kil, Steinbach, Joachim Peter, Reardon, David A, Gorlia, Thierry, Nabors, Louis Burt, Herrlinger, Ulrich, Tonn, Joerg Christian, Hicking, Christine, Picard, Martin, Hau, Peter   +36 more
core   +3 more sources

Halogenated Tryptophans Improve Integrin αVβ6 Affinity of Cyclic RGD Peptides and Provide Handles for Late‐Stage Derivatization

Chemistry – A European Journal, EarlyView.
Lighting up αVβ6: Halotryptophan engineering converts an RGD scaffold into a modular αVβ6 ligand platform, enabling picomolar affinity and late‐stage functionalization. The resulting probes combine high selectivity with fluorescence for FACS and tumor imaging.
Beate Nachtigall, Caroline Brinkmann, Jana Langosch, Anke Nieß, Norbert Sewald   +4 more
wiley   +1 more source

Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models [PDF]

, 2013
Integrins are expressed in tumor cells and tumor endothelial cells, and likely play important roles in glioma angiogenesis and invasion. We investigated the anti-glioma mechanisms of cilengitide (EMD121974), an v3 integrin inhibitor, utilizing the novel ...
Onishi, Manabu, Inoue, Satoshi, Kaur, Balveen, Ichikawa, Tomotsugu, Michiue, Hiroyuki, Date, Isao, Fujii, Kentaro, Kurozumi, Kazuhiko, Yoshida, Koichi, Chiocca, E. Antonio   +9 more
core   +1 more source

Cilengitide induces VE-cadherin loss form cellular junctions.

, 2013
(a) Confluent HUVEC plated on fibronectin, were exposed to cilengitide or EMD135981 (10 µM each) or VEGF (100 ng/ml) for 20 minutes and stained for VE-cadherin.
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source

Notch and Hedgehog Signalling Axis Drive Senescence in HER2-Positive Breast Cancer Resistant to Trastuzumab

European Journal of Biology
Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
doaj   +1 more source

Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 Infection

Viruses, 2022
The vascular barrier is heavily injured following SARS-CoV-2 infection and contributes enormously to life-threatening complications in COVID-19. This endothelial dysfunction is associated with the phlogistic phenomenon of cytokine storms, thrombotic ...
Danielle Nader, Steve W. Kerrigan
doaj   +1 more source

Cilengitide causes detachment of MPM cells in monolayer culture.

, 2014
Cells were allowed to adhere to tissue culture surface before incubation with 0, 1, or 10 µM cilengitide (CGT). Images were captured with the Zeiss Axiovert inverted microscope 1 day post-cilengitide treatment.
Glen Reid (207229), Ngan Ching Cheng (529790), Nico van Zandwijk (87878)   +2 more
core   +1 more source

Investigation of ITGB3 Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer

Biology
HER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. Trastuzumab is an FDA-approved drug and has significantly improved outcomes for patients; however, drug resistance remains ...
Asiye Busra Boz Er
doaj   +1 more source

Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats

Journal of Translational Medicine, 2018
Background To date the TGF-β1 activation mediated by integrin ανβ5 during fibrosis is well-known. This process has been shown also in the heart, where cardiac fibroblasts (CF) differentiate into α-smooth muscle actin (α-SMA)-positive myofibroblasts ...
Gianluca Lorenzo Perrucci, Veronica Antonietta Barbagallo, Maria Corlianò, Delfina Tosi, Rosaria Santoro, Patrizia Nigro, Paolo Poggio, Gaetano Bulfamante, Federico Lombardi, Giulio Pompilio   +9 more
doaj   +1 more source