Results 51 to 60 of about 35,988 (205)

The Role of αvβ3 Integrin in Lamina Cribrosa Cell Mechanotransduction in Glaucoma

Cells
Purpose: Glaucoma, one of the leading causes of irreversible blindness, is a common progressive optic neuropathy characterised by visual field defects and structural changes to the optic nerve head (ONH).
Mustapha Irnaten, Ellen Gaynor, Colm O’Brien   +2 more
doaj   +1 more source

Integrin αVβ3 Function Influences Citalopram Immobility Behavior in the Tail Suspension Test

Frontiers in Neuroscience, 2019
Human studies first identified genetic and expression interactions between integrin β3 and serotonin (5-HT) transporter (SERT) genes. This association has been further strengthened by our discovery that integrin β3-containing receptors (αvβ3) physically ...
Hope Pan, Michael R. Dohn, Rody Kingston, Ana M. D. Carneiro   +3 more
doaj   +1 more source

Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway

Scientific Reports, 2022
Gadolinium (Gd)-based contrast agents (GBCAs) are chemicals injected intravenously during magnetic resonance imaging to enhance the diagnostic yield. Repeated use of GBCAs causes their deposition in the brain.
Winda Ariyani, Wataru Miyazaki, Yoshito Tsushima, Noriyuki Koibuchi   +3 more
doaj   +1 more source

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions [PDF]

, 2010
Gene therapy is expected to open a new strategy for the treatment of refractory vascular diseases, so the development of appropriate gene vectors for vascular lesions is needed. To realize this requirement with a non-viral approach, cyclo(RGDfK) peptide (
Hideo Kagaya, Hiroyuki Koyama, Kazunori Kataoka, Makoto Oba, Takehiko Ishii, Tetsuro Miyata, Tsuyoshi Takato, Yutaka Miura   +7 more
core   +1 more source

Strategies to inhibit tumour associated integrin receptors: rationale for dual and multi-antagonists [PDF]

, 2014
YesThe integrins are a family of 24 heterodimeric transmembrane cell surface receptors. Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies integrins as therapeutic targets in cancer and associated ...
Albelda S. M., Amirkhosravi A., Aumailley M., Bandyopadhyay A., Barker P. L., Batt D. G., Bello L., Benfatti F., Bennett J. S., Bianchi-Smiraglia A., Bisanz K., Bochen A., Boys M. L., Bretschi M., Bretschi M., Brooks P. C., Buergy D., Burbridge M. F., Böger C., Calderwood D. A., Calvete J. J., Calvete J. J., Carey C. M., Chen Q., Chico T. J. A., Christoforides C., Chu F. M., Chung K.-H., Cohen S. A., Cox D., Dardik R., Davenport R. J., Davis F. B., De Corte B. L., De S., Dechantsreiter M. A., Dome B., Duan X. P., Engebraaten O., Engleman V. W., Erdreich-Epstein A., Friedlander M., Gasparini G., Gentilucci L., Gomes N., Goodman S. L., Goodman S. L., Goodman S. L., Hailey S., Harms J. F., Heidenreich A., Helen M. Sheldrake, Henderson N. C., Humphries J. D., Ishikawa M., Ishikawa M., Kang I.-C., Kerr J. S., Kim S., Knowles L. M., Kubota D., Kubota D., Kumar C. C., Laurence H. Patterson, Laurens N., Letourneau J. J., Lin E., Liu Y., Lonsdorf A. S., Lucena S. E., Malik G., Marelli U. K., Marinelli L., Marinelli L., Marinelli L., Martin P. L., Martin S., Mas-Moruno C., Mas-Moruno C., Matsuno H., Maubant S., Max R., McCabe N. P., Meerovitch K., Menendez J. A., Minea R., Minea R. O., Mitjans F., Morjen M., Mullamitha S. A., Naber H. P., Nabors L. B., Nadrah K., Nagae M., Oleksowicz L., Osterkamp F., O’Day S., O’Day S. J., Palumbo J. S., Parvani J. G., Pecheur I., Peishoff C. E., Perron-Sierra F., Pfaff M., Pontes-Júnior J., Reinmuth N., Reynolds A. R., Romanov V. I., Ross F. P., Scarborough R. M., Scarborough R. M., Scaringi C., Schaffner F., Schittenhelm J., Schittenhelm J., Schmieder A. H., Schneider J. G., Shannon K. E., Sheldrake H. M., Shih C.-H., Simon K. O., Sloan E. K., Smallheer J. M., Sowmya G., Stachurska A., Steri V., Stragies R., Sung V., Swenson S., Sánchez E. E., The IMPACT-II Investigators., Timar J., Tolomelli A., Topol E. J., Trabocchi A., Trikha M., Trikha M., Trikha M., Trikha M., van den Hoogen C., van der Flier A., van der Horst G., van der Horst G., Vermorken J. B., Vogetseder A., Wan A. M., Wu Y. J., Xiao T., Zhang W., Zhao F., Zhao Y.   +150 more
core   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Nano Diaminopropane tetrac and integrin αvβ3 expression in different cancer types: Anti-cancer efficacy and Safety

Cancer Treatment and Research Communications, 2021
Integrins are a family of heterodimeric plasma membrane glycoproteins, which regulate tumor growth, angiogenesis, migration, and metastasis. Integrin αvβ3 has been recognized as a putative target for the treatment of several cancers.
Kavitha Godugu, Thangirala Sudha, Paul J. Davis, Shaker A. Mousa   +3 more
doaj   +1 more source

Tumor-specific expression of αvβ3 integrin promotes spontaneous metastasis of breast cancer to bone [PDF]

, 2006
INTRODUCTION: Studies in xenograft models and experimental models of metastasis have implicated several beta3 integrin-expressing cell populations, including endothelium, platelets and osteoclasts, in breast tumor progression.
Erica K Sloan, Normand Pouliot, Kym L Stanley, Jenny Chia, Jane M Moseley, Daphne K Hards, Robin L Anderson, RE Coleman, RE Coleman, FG Giancotti, RE Hewitt, M Rolli, MM Zutter, H Liapis, CR Cooper, BP Eliceiri, PC Brooks, PC Brooks, JA Varner, D Taverna, B Felding-Habermann, SJ Bakewell, R Max, G Gasparini, JA Nemeth, S Silletti, Q Zhou, LE Reynolds, GC Tucker, M Pignatelli, P Clezardin, NC Wong, P van der, V Sung, JD Noti, EI Deryugina, JE Bartsch, EI Deryugina, N Gomes, M Kanamori, KA Furger, JJ Pereira, B Felding-Habermann, KE Shannon, I Pecheur, JF Harms, BL Eckhardt, M Lelekakis, CJ Aslakson, JP Morgenstern, N Pouliot, EK Sloan, SM Kakonen, AM Tester, S Takayama, S Kitazawa, E Putz, PC Baciu, EI Deryugina, EI Deryugina, G David Roodman, A Muller, ME Doerr, E Borges, M Schneller, AS Woodard, DC Lev, A Boucharaba   +67 more
core   +1 more source

Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery

ChemistryOpen, 2019
RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers.
Adina Borbély, Dr. Eduard Figueras, Ana Martins, Dr. Lizeth Bodero, Dr. André Raposo Moreira Dias, Dr. Paula López Rivas, Dr. Arianna Pina, Dr. Daniela Arosio, Dr. Paola Gallinari, Dr. Marcel Frese, Dr. Christian Steinkühler, Prof. Dr. Cesare Gennari, Prof. Dr. Umberto Piarulli, Prof. Dr. Norbert Sewald   +13 more
doaj   +1 more source