Results 1 to 10 of about 53,416 (270)
Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth [PDF]
Cell Communication and SignalingBackground Primary cilia facilitate cellular signalling and play critical roles in development, homeostasis, and disease. Their assembly is under the control of Tau-Tubulin Kinase 2 (TTBK2), a key enzyme mutated in patients with spinocerebellar ataxia ...
David Benk Vysloužil +8 more
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Composition and function of the C1b/C1f region in the ciliary central apparatus
Scientific Reports, 2021 Motile cilia are ultrastructurally complex cell organelles with the ability to actively move. The highly conserved central apparatus of motile 9 × 2 + 2 cilia is composed of two microtubules and several large microtubule-bound projections, including the ...
Ewa Joachimiak +7 more
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Scientific Reports, 2023 Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
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Cells, 2020 Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated by a less conserved linker.
Ewa Joachimiak +6 more
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Physiological Reports, 2022 Motile cilia are found in numerous locations throughout our body and play a critical role in various physiological processes. The most commonly used method to assess cilia motility is to quantify cilia beat frequency (CBF) via video microscopy.
Luke Scopulovic +3 more
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Synchronization in cilia carpets and the Kuramoto model with local coupling: breakup of global synchronization in the presence of noise [PDF]
published in: Chaos: An Interdisciplinary Journal of Nonlinear
Science 32:013124, 2022, 2021 Carpets of beating cilia represent a paradigmatic example of self-organized synchronization of noisy biological oscillators, characterized by traveling waves of cilia phase. We present a multi-scale model of a cilia carpet, which comprises realistic hydrodynamic interactions between cilia computed for a chiral cilia beat pattern from unicellular ...
arxiv +1 more source
Thermodynamic cost of synchronizing a population of beating cilia [PDF]
J. Stat. Mech. (2020) 074001, 2020 Synchronization among arrays of beating cilia is one of the emergent phenomena in biological processes at meso-scopic scales. Strong inter-ciliary couplings modify the natural beating frequencies, $\omega$, of individual cilia to produce a collective motion that moves around a group frequency $\omega_m$.
arxiv +1 more source
Intraflagellar Transport Proteins as Regulators of Primary Cilia Length
Frontiers in Cell and Developmental Biology, 2021 Primary cilia are small, antenna-like organelles that detect and transduce chemical and mechanical cues in the extracellular environment, regulating cell behavior and, in turn, tissue development and homeostasis.
Wei Wang +5 more
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Cells, 2022 Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules—nine peripheral doublets and two central singlets (9 × 2 + 2 ...
Marta Bicka +6 more
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Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis)
Toxins, 2023 Sesquiterpene lactones (SLs), plant-derived metabolites with broad spectra of biological effects, including anti-tumor and anti-inflammatory, hold promise for drug development.
Marina Murillo-Pineda +9 more
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