Results 1 to 10 of about 49,689 (263)

Primary cilia gene defects in BMSCs induce idiopathic scoliosis [PDF]

Cellular and Molecular Life Sciences
This paper investigated the role of cilia gene defects in bone marrow stem cells (BMSCs) in idiopathic scoliosis (IS). IS, a spinal deformity commonly occurring in adolescence, impacts patients’ quality of life. Cilia, axial filaments covered by the cell
Li Zhang, Wenhui Yang, Zhi Zhao, Yingsong Wang, Haonan Wang, Ninghui Zhao, Jin Zhou, Zhibo Song, Zhaoquan Zhang, Tao Li, Shangjia Zhe, Genghao Qian, Yingliang Liu, Jingming Xie   +13 more
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Composition and function of the C1b/C1f region in the ciliary central apparatus

Scientific Reports, 2021
Motile cilia are ultrastructurally complex cell organelles with the ability to actively move. The highly conserved central apparatus of motile 9 × 2 + 2 cilia is composed of two microtubules and several large microtubule-bound projections, including the ...
Ewa Joachimiak, Anna Osinka, Hanan Farahat, Bianka Świderska, Ewa Sitkiewicz, Martyna Poprzeczko, Hanna Fabczak, Dorota Wloga   +7 more
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Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes

Scientific Reports, 2023
Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj   +1 more source

The LisH Domain-Containing N-Terminal Fragment is Important for the Localization, Dimerization, and Stability of Katnal2 in Tetrahymena

Cells, 2020
Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated by a less conserved linker.
Ewa Joachimiak, Ewa Waclawek, Michal Niziolek, Anna Osinka, Hanna Fabczak, Jacek Gaertig, Dorota Wloga   +6 more
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Quantifying cilia beat frequency using high‐speed video microscopy: Assessing frame rate requirements when imaging different ciliated tissues

Physiological Reports, 2022
Motile cilia are found in numerous locations throughout our body and play a critical role in various physiological processes. The most commonly used method to assess cilia motility is to quantify cilia beat frequency (CBF) via video microscopy.
Luke Scopulovic, Deanne Francis, Elvis Pandzic, Richard Francis   +3 more
doaj   +1 more source

Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in Tetrahymena Cilia

Cells, 2022
Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules—nine peripheral doublets and two central singlets (9 × 2 + 2 ...
Marta Bicka, Ewa Joachimiak, Paulina Urbanska, Anna Osinka, Anna Konopka, Ewa Bulska, Dorota Wloga   +6 more
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Intraflagellar Transport Proteins as Regulators of Primary Cilia Length

Frontiers in Cell and Developmental Biology, 2021
Primary cilia are small, antenna-like organelles that detect and transduce chemical and mechanical cues in the extracellular environment, regulating cell behavior and, in turn, tissue development and homeostasis.
Wei Wang, Brittany M. Jack, Henry H. Wang, Matthew A. Kavanaugh, Robin L. Maser, Pamela V. Tran   +5 more
doaj   +1 more source

Cilia and cilia-associated proteins in cancer [PDF]

Drug Discovery Today: Disease Mechanisms, 2013
The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors.
Tamina, Seeger-Nukpezah, Joy L, Little, Victoria, Serzhanova, Erica A, Golemis   +3 more
openaire   +2 more sources

Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis)

Toxins, 2023
Sesquiterpene lactones (SLs), plant-derived metabolites with broad spectra of biological effects, including anti-tumor and anti-inflammatory, hold promise for drug development.
Marina Murillo-Pineda, Juan M. Coto-Cid, María Romero, Jesús G. Zorrilla, Nuria Chinchilla, Zahara Medina-Calzada, Rosa M. Varela, Álvaro Juárez-Soto, Francisco A. Macías, Elena Reales   +9 more
doaj   +1 more source

Ependymal cilia beating induces an actin network to protect centrioles against shear stress

Nature Communications, 2018
Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alexia Mahuzier, Asm Shihavuddin, Clémence Fournier, Pauline Lansade, Marion Faucourt, Nikita Menezes, Alice Meunier, Meriem Garfa-Traoré, Marie-France Carlier, Raphael Voituriez, Auguste Genovesio, Nathalie Spassky, Nathalie Delgehyr   +12 more
doaj   +1 more source