Results 1 to 10 of about 164,456 (390)

Intraflagellar Transport Proteins as Regulators of Primary Cilia Length

Frontiers in Cell and Developmental Biology, 2021
Primary cilia are small, antenna-like organelles that detect and transduce chemical and mechanical cues in the extracellular environment, regulating cell behavior and, in turn, tissue development and homeostasis.
Wei Wang, Brittany M. Jack, Henry H. Wang, Matthew A. Kavanaugh, Robin L. Maser, Pamela V. Tran   +5 more
doaj   +2 more sources

Primary cilia gene defects in BMSCs induce idiopathic scoliosis [PDF]

Cellular and Molecular Life Sciences
This paper investigated the role of cilia gene defects in bone marrow stem cells (BMSCs) in idiopathic scoliosis (IS). IS, a spinal deformity commonly occurring in adolescence, impacts patients’ quality of life. Cilia, axial filaments covered by the cell
Li Zhang, Wenhui Yang, Zhi Zhao, Yingsong Wang, Haonan Wang, Ninghui Zhao, Jin Zhou, Zhibo Song, Zhaoquan Zhang, Tao Li, Shangjia Zhe, Genghao Qian, Yingliang Liu, Jingming Xie   +13 more
doaj   +2 more sources

CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells [PDF]

Frontiers in Endocrinology
IntroductionCysteine cathepsins K and L are crucial for proper thyroid function in mice. Inhibition of cysteine peptidases in rodent thyroid epithelial cells in vitro results in loss of primary cilia, highlighting the significance of proteolysis for ...
Maren Rehders, Kseniia Alekseitseva, João Gissoni, Alara G. Doğru, Petr Popov, Petr Popov, Petr Popov, Andrei Boiarov, Klaudia Brix   +8 more
doaj   +2 more sources

Cellular signalling by primary cilia in development, organ function and disease

Nature Reviews Nephrology, 2019
Kirk Mykytyn, Saikat Mukhopadhyay, Lotte B Pedersen   +2 more
exaly   +2 more sources

A change of heart: new roles for cilia in cardiac development and disease

Nature Reviews Cardiology, 2021
Lydia Djenoune, Martina Brueckner, Shiaulou Yuan   +2 more
exaly   +2 more sources

Establishing and regulating the composition of cilia for signal transduction

Nature Reviews Molecular Cell Biology, 2019
Maxence V Nachury, David U Mick
exaly   +2 more sources

Impact of cilia length and variable fluid properties on electroosmotic nanofluid flow in an inclined converging microchannel. [PDF]

Sci Rep
Sadalagi P, Choudhari R, Vaidya H, Gudekote M, Prasad KV.   +4 more
europepmc   +3 more sources

Primary cilia as dynamic and diverse signalling hubs in development and disease

Nature reviews genetics, 2023
Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate cell types, are essential for regulating signalling pathways during development and adult homeostasis.
P. Mill, S. Christensen, L. B. Pedersen
semanticscholar   +1 more source

Immotile cilia mechanically sense the direction of fluid flow for left-right determination

Science, 2023
Immotile cilia at the ventral node of mouse embryos are required for sensing leftward fluid flow that breaks left-right symmetry of the body. However, the flow-sensing mechanism has long remained elusive.
Takanobu A. Katoh, T. Omori, K. Mizuno, Xiaorei Sai, Katsura Minegishi, Yayoi Ikawa, Hiromi Nishimura, Takeshi Itabashi, Eriko Kajikawa, Sylvain Hiver, A. Iwane, Takuji Ishikawa, Yasushi Okada, T. Nishizaka, H. Hamada   +14 more
semanticscholar   +1 more source

Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry

Science, 2023
The breaking of bilateral symmetry in most vertebrates is critically dependent upon the motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid flow; however, it remains unclear how this flow is sensed.
Lydia Djenoune, Mohammed Mahamdeh, Thai V. Truong, C. Nguyen, S. Fraser, M. Brueckner, Jonathon Howard, Shiaulou Yuan   +7 more
semanticscholar   +1 more source