Results 191 to 200 of about 51,025 (263)

Primary cilia regulate GLP-1 signaling in pancreatic β cells. [PDF]

Mol Metab
Melena I, Jo JH, Townsend SE, DiGruccio SA, Dong X, Zhu L, Campbell J, Hughes JW.   +7 more
europepmc   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia. [PDF]

Mol Biol Cell
Lettieri KS, McNeely KC, Dwyer ND.
europepmc   +1 more source

Rebuilding the Mucociliary Apparatus in ECRS: TSLP/IL-33 Signaling Synergy and the Residual Molecular Scar of <i>DNASE1L3</i> Following IL-4/13 Blockade. [PDF]

Cells
Fujita R, Ishino T, Oda T, Kawasumi T, Nishida M, Horibe Y, Chikuie N, Taruya T, Hamamoto T, Ueda T, Takeno S.   +10 more
europepmc   +1 more source

Biopsy of Iris and Anterior Chamber Tumours: Fine Needle, Minimally Invasive and Excision Techniques ‐ Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Several benign, inflammatory and malignant lesions can present as iris or anterior chamber masses, including iris naevi, cysts, adenomas, leiomyomas, nodules, vascular tumours, melanomas, metastases, as well as iris and pigment epithelium adenocarcinomas. Fortunately, benign iris lesions are much more common than malignant tumours and many can
Charles N. J. McGhee, Joevy Z. Lim, Peter W. Hadden, Jie Zhang   +3 more
wiley   +1 more source

Cilia Dynamics in Primary Ciliary Dyskinesia: A Biophysical Characterization of the <i>RSPH4A</i> Founder Variant. [PDF]

Cells
Rosario-Ortiz G, Muñiz-Hernández J, Ortiz-Pérez NM, Ramos-Benitez MJ, Mosquera RA, De Jesús-Rojas W.   +5 more
europepmc   +1 more source

Australian and New Zealand Glaucoma Society (ANZGS) Consensus on Interventional Glaucoma

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Traditional reactive ‘wait and see’ approaches in glaucoma management often result in unacceptable rates of permanent vision loss. This consensus defines a proactive ‘interventional glaucoma’ framework tailored for the Australian and New Zealand healthcare context. Methods A modified Delphi consensus process was utilised, consisting
Graham A. Lee, Lance Liu, Ridia Lim, Rajiv Shah, Robert J. Casson, Keith R. Martin, Helen Danesh‐Meyer, Ashish Agar, Jennifer C. Fan Gaskin, Judy Y. Ku, Geoffrey Chan, Anna Galanopoulos, Shamira Perera   +12 more
wiley   +1 more source

Crashing by design: Utilizing DNA damage for MCC differentiation. [PDF]

Trends Cell Biol
Suva EE, Mitchell BJ.
europepmc   +1 more source

Biallelic Truncating Variant in LRGUK Is Associated With Severe Multiple Morphological Abnormalities of the Sperm Flagella and Sperm Nuclear Defects in Humans

Clinical Genetics, EarlyView.
A homozygous truncating variant in LRGUK results in loss of the LRGUK protein and causes multiple morphological abnormalities of the flagella (MMAF), disrupted axonemal architecture, central pair defects, abnormal chromatin organization, and severe male infertility, establishing LRGUK as a novel human infertility gene.
Wiâme Mokkedem, Zeina Wehbe, Anne‐Laure Barbotin, Angèle Boursier, Célia Tebbakh, Nicolas Thierry‐Mieg, Marie Bidart, Antonella Migliaccio, Rosanna Chianese, Christophe Arnoult, Raoudha Zouari, Zine‐Eddine Kherraf, Pierre F. Ray, Guillaume Martinez, Charles Coutton   +14 more
wiley   +1 more source

Recombinant monoclonal antibodies for labeling tubulin post-translational modifications in <i>Caenorhabditis elegans</i>. [PDF]

MicroPubl Biol
Dobossy L, Wang J, Verhey KJ, Barr M.
europepmc   +1 more source