Results 21 to 30 of about 53,416 (270)
Cells, 2019 Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka +5 more
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IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning
Nature Communications, 2017 Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet +8 more
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Rediscovering Primary Cilia in Pancreatic Islets [PDF]
Diabetes & Metabolism Journal, 2023 Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
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Cilia beating patterns are not hydrodynamically optimal [PDF]
Phys. Fluids 26, 091901 (2014), 2014 We examine the hydrodynamic performance of two cilia beating patterns reconstructed from experimental data. In their respective natural systems, the two beating patterns correspond to: (A) pumping-specialized cilia, and (B) swimming-specialized cilia.
arxiv +1 more source
Hydrodynamic flow patterns and synchronization of beating cilia [PDF]
Phys. Rev. Lett. 96, 058102 (2006), 2005 We calculate the hydrodynamic flow field generated far from a cilium which is attached to a surface and beats periodically. In the case of two beating cilia, hydrodynamic interactions can lead to synchronization of the cilia, which are nonlinear oscillators.
arxiv +1 more source
Chemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022 The chemical evolution of polyketide natural products leads to the unprecedented combination of biosynthetically related fragments in arrangements not found in Nature. The pseudo‐natural product grismonone was identified to be a potent inhibitor of Hedgehog signaling – a bioactivity that is not shared by its guiding fragments.
Michael Grigalunas +9 more
wiley +1 more source
The Importance of Zebrafish in Biomedical Research
Acta Médica Portuguesa, 2013 Introduction: Zebrafish (Danio rerio) is an ideal model organism for the study of vertebrate development. This is due to the large clutches that each couple produces, with up to 200 embryos every 7 days, and to the fact that the embryos and larvae are ...
Bárbara Tavares, Susana Santos Lopes
doaj +1 more source
Fluorescence imaging of beta cell primary cilia
Frontiers in Endocrinology, 2022 Primary cilia are slender cell-surface organelles that project into the intercellular space. In pancreatic beta cells, primary cilia coordinate a variety of cell responses including GPCR signaling, calcium influx, and insulin secretion, along with likely
Zipeng A. Li +3 more
doaj +1 more source
A dynamical model of the spindle position checkpoint
Molecular Systems Biology, 2012 The orientation of the mitotic spindle with respect to the polarity axis is crucial for the accuracy of asymmetric cell division. In budding yeast, a surveillance mechanism called the spindle position checkpoint (SPOC) prevents exit from mitosis when the
Ayse Koca Caydasi +5 more
doaj +1 more source
PLoS Genetics, 2020 Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse.
Takahiro Ide +12 more
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