Results 31 to 40 of about 53,999 (295)

Smoking is associated with shortened airway cilia. [PDF]

PLoS ONE, 2009
BACKGROUND:Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length.
Philip L Leopold, Michael J O'Mahony, X Julie Lian, Ann E Tilley, Ben-Gary Harvey, Ronald G Crystal   +5 more
doaj   +1 more source

Neuronal cilia in energy homeostasis

Frontiers in Cell and Developmental Biology, 2022
A subset of genetic disorders termed ciliopathies are associated with obesity. The mechanisms behind cilia dysfunction and altered energy homeostasis in these syndromes are complex and likely involve deficits in both development and adult homeostasis ...
Kathryn M. Brewer, Katlyn K. Brewer, Nicholas C. Richardson, Nicolas F. Berbari, Nicolas F. Berbari, Nicolas F. Berbari   +5 more
doaj   +1 more source

Maintaining centrosomes and cilia [PDF]

Journal of Cell Science, 2017
ABSTRACT Centrosomes and cilia are present in organisms from all branches of the eukaryotic tree of life. These structures are composed of microtubules and various other proteins, and are required for a plethora of cell processes such as structuring the cytoskeleton, sensing the environment, and motility.
Sascha Werner, Ana Pimenta-Marques, Mónica Bettencourt-Dias   +2 more
openaire   +3 more sources

A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia

Frontiers in Cellular Neuroscience, 2019
In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco, Katja Baur, Andrea Hellwig, Gabriele Hölzl-Wenig, Claudia Mandl, Francesca Ciccolini   +5 more
doaj   +1 more source

Cilia Action in Islets: Lessons From Mouse Models

Frontiers in Endocrinology, 2022
Primary cilia as a signaling organelle have garnered recent attention as a regulator of pancreatic islet function. These rod-like sensors exist on all major islet endocrine cell types and transduce a variety of external cues, while dysregulation of cilia
Jung Hoon Cho, Jing W. Hughes
doaj   +1 more source

A transgenic zebrafish for in vivo visualization of cilia

Open Biology, 2022
Cilia are organelles for cellular signalling and motility. Mutations affecting ciliary function are also associated with cilia-related disorders (ciliopathies).
Hongyu Zhang, Zhuoya Huang, Liuliu LV, Yuye Xin, Qian Wang, Feng Li, Lina Dong, Changxin Wu, Philip W. Ingham, Zhonghua Zhao   +9 more
doaj   +1 more source

Assembly of primary cilia [PDF]

Developmental Dynamics, 2008
AbstractPrimary cilia are microtubule‐based, hair‐like sensory organelles present on the surface of most growth‐arrested cells in our body. Recent research has demonstrated a crucial role for primary cilia in regulating vertebrate developmental pathways and tissue homeostasis, and defects in genes involved in primary cilia assembly or function have ...
Pedersen, Lotte B, Veland, Iben R, Schrøder, Jacob M, Christensen, Søren T   +3 more
openaire   +4 more sources

Pathway Analyses of Inherited Neuropathies Identify Putative Common Mechanisms of Axon Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Inherited neuropathies (IN) are associated with over 100 different genetic mutations presenting with a variety of phenotypes. This complexity suggests multiple pathways may converge onto a limited number of downstream pathways to effect axonal injury.
Christopher R. Cashman, Craig Blackstone, Reza Sadjadi   +2 more
wiley   +1 more source

Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth

Cell Communication and Signaling
Background Primary cilia facilitate cellular signalling and play critical roles in development, homeostasis, and disease. Their assembly is under the control of Tau-Tubulin Kinase 2 (TTBK2), a key enzyme mutated in patients with spinocerebellar ataxia ...
David Benk Vysloužil, Ondřej Bernatík, Eva Lánská, Tereza Renzová, Lucia Binó, Andrea Lacigová, Tereza Drahošová, Zdeněk Lánský, Lukáš Čajánek   +8 more
doaj   +1 more source

Cilia - the prodigal organelle [PDF]

Cilia, 2012
Cilia are the oldest known cellular organelle, first described in 1675 by Anthony van Leeuwenhoek in protozoa [1]. He described them as 'incredibly thin feet, or little legs, which were moved very nimbly'. The term 'cilium' (Latin for eyelash) was probably first coined by Otto Muller in 1786 [2].
Peter K. Jackson, PL Beales
openaire   +3 more sources