Advanced Science, EarlyView.Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng +9 more
wiley +1 more source
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells [PDF]
, 2012 Mitsuru Morimoto +3 more
openalex +1 more source
Advanced Science, EarlyView.Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li +3 more
wiley +1 more source
In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells [PDF]
, 2017 Arnab Ghosh +2 more
openalex +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Bio‐Inspired Micro‐Fin‐Assisted Multi‐Modal Vascular Intervention
Advanced Science, EarlyView.A magnetic guidewire with a micro‐fin–integrated tip is introduced for multimodal cardiovascular navigation. The micro‐fins exploit fluid drag to augment magnetic torque, enabling bifurcation traversal at 15 mT, tolerating 45° misalignment, bidirectional crawling, and buckle self‐correction.
Xu Liu +8 more
wiley +1 more source
Ciliated protozoa in the impact zone of the Uzhgorod treatment plant
E3S Web of Conferences, 2018 This paper presents the results of studies on the Uzh River (Ukraine, Zakarpattia Oblast) near the effluent point of a sewage treatment plant in Uzhgorod.
Pliashechnyk Volodimir +5 more
doaj +1 more source
Distribution and diversity of oligotrich and choreotrich ciliates across an environmental gradient in a large temperate estuary [PDF]
, 2011 Maiko Tamura +2 more
openalex +1 more source
Systematic description and key to isolants from Atacama Desert, Chile [PDF]
Isolation and identification of desert soil microorganism from ...
Au, F., Bollen, W. B., Byers, K. M.
core +1 more source