Results 131 to 140 of about 19,567 (308)
Stages of ciliogenesis and regulation of ciliary length [PDF]
Differentiation, 2012 Cilia and flagella are highly conserved eukaryotic microtubule-based organelles that protrude from the surface of most mammalian cells. These structures require large protein complexes and motors for distal addition of tubulin and extension of the ciliary membrane. In order for ciliogenesis to occur, coordination of many processes must take place.
Prachee Avasthi, Wallace F. Marshall
openaire +3 more sources
Clinical and Translational Allergy, 2022 Background Hypoxia is considered a key factor in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the specific mechanism driving polypogenesis under hypoxic conditions is unclear. This study aimed to explore hypoxia‐induced
Jian Jiao +6 more
doaj +1 more source
VDAC3 and Mps1 negatively regulate ciliogenesis [PDF]
Cell Cycle, 2013 Centrosomes serve to organize new centrioles in cycling cells, whereas in quiescent cells they assemble primary cilia. We have recently shown that the mitochondrial porin VDAC3 is also a centrosomal protein that is predominantly associated with the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.
Shubhra Majumder, Harold A. Fisk
openaire +3 more sources
Nature Communications, 2018 Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al.
Ning Huang +6 more
doaj +1 more source
Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation. [PDF]
, 2012 Primary cilia are cellular appendages important for signal transduction and sensing the environment. Bardet-Biedl syndrome proteins form a complex that is important for several cytoskeleton-related processes such as ciliogenesis, cell migration and ...
Beales, PL +6 more
core +4 more sources
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade
Life Science Alliance, 2020 Pathogenic LRRK2 phosphorylation of Rab10 GTPase dramatically redistributes Myosin Va and RILPL2 proteins to the mother centriole and sequesters Myosin Va at that location in a manner that likely interferes with its role in ciliogenesis.
H. S. Dhekne +6 more
semanticscholar +1 more source
Human efferent ductules and epididymis display unique cell lineages with motile and primary cilia
Andrology, Volume 13, Issue 4, Page 894-910, May 2025.Abstract Background Previous research has illustrated the role of cilia as mechanical and sensory antennae in various organs within the mammalian male reproductive system across different developmental stages. Despite their significance in both organ development and homeostasis, primary cilia in the human male reproductive excurrent duct have been ...
Ludovic Vinay +2 more
wiley +1 more source
Ciliogenesis, Ciliary Function, and Selective Isolation [PDF]
ACS Chemical Biology, 2008 In addition to their classic role in cell motility, certain cilia have sensory or signaling functions. In sea urchin embryos, short motile cilia randomly propel the early embryo, while a group of long, immotile cilia appear later, coincident with directional swimming and localized within a region that gives rise to the larval nervous system.
openaire +3 more sources
Development and disease of the photoreceptor cilium [PDF]
, 2009 Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues.
Adams +48 more
core +1 more source
Human Molecular Genetics, 2019 Mutations in the LRRK2 kinase are the most common cause of familial Parkinson’s disease, and variants increase risk for the sporadic form of the disease. LRRK2 phosphorylates multiple RAB GTPases including RAB8A and RAB10.
A. J. Lara Ordóñez +11 more
semanticscholar +1 more source