Results 261 to 270 of about 41,549 (330)

Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the Zfyve19−/− mouse model

Pediatric Investigation, EarlyView.
THBA (3α,6α,7α,12α‐Tetrahydroxy‐10β,13β‐pentanoic acid) administration can alleviate cholestatic liver injury, hepatocellular necrosis, inflammatory response, bile duct hyperplasia, and portal fibrosis in the Zfyve19−/− mouse model. This evaluation encompasses various parameters, including serum biochemistry, liver histology, immunostaining, and ...
Li Wang, Yue Yu, Jiayan Feng, Yanan Zhang, Renxue Wang, Huiyu She, Teng Liu, Victor Ling, Jianshe Wang   +8 more
wiley   +1 more source

Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis. [PDF]

Proc Natl Acad Sci U S A
Sakai T, Kawakita M, Seki A, Takaoka K, Kurata M, Torikai J, Atsumi S, Yawata K, Noi K, Fukutani Y, Noguchi K, Kiyokawa H, Morimoto M, Takeuchi E, Minegishi K, Aoki Y, Fujimura S, Nishizaka T, Inoue T, Nagaoka K, Tsugawa H, Hayashi H, Ishiguro H, Kozono T, Ohsawa I, Fujita Y, Matsunami H, Hamada H, Shinohara K.   +28 more
europepmc   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Management of a large plant-derived foreign body under the plica semilunaris: a case report. [PDF]

BMC Ophthalmol
Zhao J, Zhang Q, Xu Z.
europepmc   +1 more source

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

Small, EarlyView.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins, Louise Bondeelle, Arnaud Charles‐Antoine Zwygart, Thais Melquiades de Lima, Juliano de Paula Souza, Han Kang Tee, Fernando Chahud, Eurico de Arruda Neto, Francesco Stellacci, Renata Fonseca Vianna Lopez, Caroline Tapparel   +10 more
wiley   +1 more source

Golgi-localized phosphatidylinositol 4-kinase β mediates Rab11a activation and trafficking to promote ciliogenesis. [PDF]

Sci Adv
Wang L, Sun J, Sun S, Huang Z, Liu Y, Yan S, Sun C, Feng Q, Fu W, Zhong T, Zhang J, Zhou J, Liu P.   +12 more
europepmc   +1 more source

Filomicelle‐Embedded Composite Hydrogels for Localized Gelation Within the Anterior Chamber of the Eye

Small, EarlyView.
A composite hydrogel (C‐gel) incorporating PEG‐b‐PPS filomicelles enables localized in situ gelation and sustained nanocarrier release within the anterior chamber. The filamentous structure promotes spatial confinement of multi‐arm polymer crosslinking, even upon injection into large aqueous volumes, and gradually transitions into spherical micelles ...
Hyeohn Kim, Sofia Lara Ochoa, Swagat Sharma, Asmaa A. Youssif, Benjamin R Thomson, Mark Johnson, Evan A. Scott   +6 more
wiley   +1 more source

Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells. [PDF]

Bioessays
Ott CM, Mukhopadhyay S.
europepmc   +1 more source

Cilium length regulation in Caenorhabditis elegans

, 2019
Kwangjin Park
openalex   +1 more source

GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration

Théo Paillard, Ada Allam, Mohamed Doulazmi, Mathieu Hautefeuille, Coralie Fouquet, Liza Sarde, Julie Stoufflet, Salima Messaoudi, Nathalie Spassky, Stéphane Nedelec, Isabelle Dusart, Alain Trembleau, Isabelle Caillé   +12 more
openalex   +1 more source