Results 261 to 270 of about 36,064 (332)

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling

, 2012
Moe R. Mahjoub, Tim Stearns
openalex   +1 more source

Bioinformatics‐Based Comparative Analysis of the Human Retina Proteome

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Introduction The human retina relies on a complex network of proteins, many of which exhibit intrinsic disorder and liquid‐liquid phase separation (LLPS), enabling dynamic interactions for retinal function. Disruptions in these properties, along with missense mutations, have been linked to retinal diseases.
Colin K. Kim, Mak B. Djulbegovic, David Broytman, Nedym Hadzijahic, Michael Antonietti, David J. Taylor Gonzalez, Vladimir N. Uversky, Nicolas A. Yannuzzi, Carol L. Karp   +8 more
wiley   +1 more source

Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function. [PDF]

EMBO J
Nilsson CI, Dumral Ö, Sanchez G, Xie B, Müller A, Solimena M, Ren H, Idevall-Hagren O.   +7 more
europepmc   +1 more source

The extreme short‐term rainfall rate as caused by a convective storm under a beneficial dynamic pattern

Quarterly Journal of the Royal Meteorological Society, EarlyView.
In this study, a nocturnal extreme rainfall event was examined by using cloud‐permitting simulations with the Weather Research and Forecasting model. We proposed a mechanism for extreme short‐term rainfall formation under a beneficial dynamic pattern within a convective storm, and the mechanism is confirmed by a trajectory analysis of raindrops based ...
Jinfang Yin, Rudi Xia, Mingxin Li, Haoran Li, Xudong Liang   +4 more
wiley   +1 more source

The BBS/CCT chaperonin complex ensures the localization of the adhesion G protein-coupled receptor ADGRV1 to the base of primary cilia. [PDF]

Front Cell Dev Biol
Linnert J, Kusuluri DK, Güler BE, Patnaik SR, May-Simera HL, Wolfrum U.   +5 more
europepmc   +1 more source

Frontal Sinus Patency After Sinus Surgery Using Triamcinolone‐Impregnated Plant‐Based Sinus Spacers

The Laryngoscope, EarlyView.
Emily Ajit‐Roger, Deema Almutawa, Mahmoud Abdullah Alageeli, Marc A. Tewfik   +3 more
wiley   +1 more source

Secretome Profiling in Axon Regeneration: Emerging Techniques and Therapeutic Translation

Sensory Neuroscience, EarlyView.
ABSTRACT The secretome refers to the in vivo ensemble of molecular entities that are found in interstitial spaces. It is then the mere secreted products of the cells, as all biomolecules in the interstitial cellular spaces also undergo modifications. The fractionated secretome may hold potential as a cell‐free therapy option due to its role in tissue ...
Maria D. Cabrera, Nicole Ramones, Isabella Moceri, Sanjoy K. Bhattacharya   +3 more
wiley   +1 more source

Sensory stimuli and cilium trafficking defects trigger the release of ciliary extracellular vesicles from multiple ciliary locations

Lobo T, Haasnoot GH, Nawrocka A, Bruggeman CW, Razzauti A, Peterman EJ, Laurent P.   +6 more
europepmc   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications. [PDF]

Adv Sci (Weinh)
Wang Z, Zhu X, Huang Z, Ren K, Ran J, Yang Y.   +5 more
europepmc   +1 more source