Results 251 to 260 of about 29,037 (298)
Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure. [PDF]
J Cell BiolPark JH +6 more
europepmc +1 more source
Gene-transcription factor regulatory networks implicate primary cilia in the evolution of vertebrate sex determination and expand models of epigenetic regulation. [PDF]
PLoS OneGessler TB, Adams DC, Valenzuela N.
europepmc +1 more source
Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons. [PDF]
Cell Biochem FunctVos N +8 more
europepmc +1 more source
Primary Cilium in Cancer Hallmarks
International Journal of Molecular Sciences, 2019 International audienceThe primary cilium is a solitary, nonmotile and transitory appendage that is present in virtually all mammalian cells. Our knowledge of its ultrastructure and function is the result of more than fifty years of research that has ...
N M Mazure +2 more
exaly +2 more sources
The Primary Cilium and Neuronal Migration
Cells, 2022 The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons. The extremely severe phenotypes of ciliopathies have suggested their paramount importance for multiple developmental events, including brain formation.
Isabelle Caille, Julie Stoufflet
exaly +6 more sources
Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility.
John Hancock, Gabrielle Wheway
exaly +4 more sources
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American Journal of Anatomy, 1975
AbstractThe connective tissue cells of the dentinal pulp of unerupted dog teeth possess occasional cilia. Internally there are 4 to 8 peripheral doublets and one central doublet. Nine peripheral doublets are observed only close to or near the basal body.
K, Kubota, J J, Malloy, F N, Low
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AbstractThe connective tissue cells of the dentinal pulp of unerupted dog teeth possess occasional cilia. Internally there are 4 to 8 peripheral doublets and one central doublet. Nine peripheral doublets are observed only close to or near the basal body.
K, Kubota, J J, Malloy, F N, Low
openaire +2 more sources
The Anatomical Record, 1969
AbstractIn the course of ultrastructural studies on the cerebellar cortex of young rats a cilium was found in some Purkinje cells. The shaft, which is 1800 to 2000 ÅR thick, has an internal portion inside the cell body and an external one projecting into the neuropile. The basal body is consistently located near the Golgi apparatus.
Manuel P. Del Cerro +2 more
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AbstractIn the course of ultrastructural studies on the cerebellar cortex of young rats a cilium was found in some Purkinje cells. The shaft, which is 1800 to 2000 ÅR thick, has an internal portion inside the cell body and an external one projecting into the neuropile. The basal body is consistently located near the Golgi apparatus.
Manuel P. Del Cerro +2 more
openaire +2 more sources
A PHYSIOLOGICAL VIEW OF THE PRIMARY CILIUM
Annual Review of Physiology, 2005▪ Abstract The primary cilium, an organelle largely ignored by physiologists, functions both as a mechano-sensor and a chemo-sensor in renal tubular epithelia. This forgotten structure is critically involved in the determination of left-right sidedness during development and is a key factor in the development of polycystic kidney disease, as well as ...
Prætorius, Helle A., Spring, Kenneth R.
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2014
The protein CEP290 has recently emerged as a major player in the biology of the cilium and as a causative protein in a number of human syndromic diseases, most of which are associated with the devastating blinding disease Leber congenital amaurosis. (Coppieters et al., Hum Mutat 31, 2010, 1097-1108) CEP290 is known to be an important component of the ...
Theodore G, Drivas, Jean, Bennett
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The protein CEP290 has recently emerged as a major player in the biology of the cilium and as a causative protein in a number of human syndromic diseases, most of which are associated with the devastating blinding disease Leber congenital amaurosis. (Coppieters et al., Hum Mutat 31, 2010, 1097-1108) CEP290 is known to be an important component of the ...
Theodore G, Drivas, Jean, Bennett
openaire +2 more sources