Results 61 to 70 of about 34,354 (355)
Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar +32 more
core +1 more source
The dynamic cilium in human diseases [PDF]
PathoGenetics, 2009 Cilia are specialized organelles protruding from the cell surface of almost all mammalian cells. They consist of a basal body, composed of two centrioles, and a protruding body, named the axoneme. Although the basic structure of all cilia is the same, numerous differences emerge in different cell types, suggesting diverse functions.
A. D’Angelo, FRANCO, BRUNELLA
openaire +3 more sources
Chemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022 The chemical evolution of polyketide natural products leads to the unprecedented combination of biosynthetically related fragments in arrangements not found in Nature. The pseudo‐natural product grismonone was identified to be a potent inhibitor of Hedgehog signaling – a bioactivity that is not shared by its guiding fragments.
Michael Grigalunas +9 more
wiley +1 more source
Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
Frontiers in Endocrinology, 2022 The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication ...
Marta Pablos +7 more
doaj +1 more source
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
core +2 more sources
Mathematical Biosciences and Engineering, 2021 Primary cilia are non-motile, solitary (one per cell) microtubule-based organelles that emerge from the mother centriole after cells have exited the mitotic cycle.
Zhangli Peng +2 more
doaj +1 more source
Mixing and transport by ciliary carpets: a numerical study [PDF]
, 2013 We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a fluid mixing ...
Ding, Yang +3 more
core +3 more sources
Thermodynamic cost of synchronizing a population of beating cilia [PDF]
J. Stat. Mech. (2020) 074001, 2020 Synchronization among arrays of beating cilia is one of the emergent phenomena in biological processes at meso-scopic scales. Strong inter-ciliary couplings modify the natural beating frequencies, $\omega$, of individual cilia to produce a collective motion that moves around a group frequency $\omega_m$.
arxiv +1 more source
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]
, 2015 Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista +51 more
core +1 more source
Developmental Dynamics, Volume 251, Issue 12, Page 1968-1981, December 2022., 2022 Abstract Background Injury response is key to successful regeneration. Yet, transcriptome analyses of injury response were performed only on a handful of regenerative organisms. Here, we studied the injury response of the solitary ascidian Polycarpa mytiligera, an emerging model system, capable of regenerating any body part.
Noam Hendin +3 more
wiley +1 more source